Zusammenfassung
Maligne Lymphome (ML) können das ZNS in mehrfacher Weise betreffen: 1. als isolierte “primäre” Läsion ohne (oder mit späterer) extraneuraler Organbeteiligung; 2. durch Dissemination oder Fortleitung einer Systemerkrankung oder 3. durch Komplikationen, Zweitschäden und paraneoplastische Syndrome. Beschrieb Burns (23) 1811 erstmals eine ZNS-Beteiligung bei Leukosen (Chlorom der Dura mit Paraplegie), lieferte 1869 Murchison (143) die erste Beobachtung von ZNS-Befall bei ML (Infiltration der Dura nahe dem Foramen magnum bei 6-jährigem Knaben mit mediastinalem ML) und Askanazy (4) 1921 jene bei M. Hodgkin (MH). Welch (226) erwähnte 1910 erstmals eine Rückenmarkskompression durch ein epidurales Lymphom. Hirngeschwülste mit Beziehung zum lymphoreti-kulären System wurden zuerst 1921 von Bailey (5) als “Perithelialsarkome” beschrieben und bis vor kurzem als “Mikrogliome” (69, 77, 135, 185) oder “Retikulumzellsarkom-Mikrogliome” (1, 183, 188) als eigene Entität subsumiert. Heute gilt die zytologische und immunologische Identität der “primären” ML (PL) des ZNS mit den extraneuralen ML als gesichert (34, 80, 85, 86, 90, 94–97, 138, 211) und ihre einheitliche histologische Klassifikation als gerechtfertigt.
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Jellinger, K. (1983). Primäre und sekundäre Lymphome des Zentralnervensystems. In: Seitz, D., Vogel, P. (eds) Hämoblastosen Zentrale Motorik Iatrogene Schäden Myositiden. Verhandlungen der Deutschen Gesellschaft für Neurologie, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-45561-2_2
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