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Experimental Production of Diseases pp 1–120Cite as

Experimental Hepatotoxicity

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Abstract

The literature of experimental hepatotoxicity has become so enormous as to overwhelm the effort to summarize the current state of knowledge. Excellent reviews [126, 498, 472, 348, 342, 418, 325, 430, 190, 269, 240, 286, 517, 490, 432] that have been published during the past several decades have assisted the present effort considerably. This review includes a survey of the broad aspects of hepatotoxicity, categorization of types of hepatic injury and discussion of presumed mechanisms followed by a description of the details of the injury produced by a few specific agents. Reference made to hepatocarcinogenicity is restricted to its relationship to hepatotoxicity. The last section contains an analysis of the character of injury according to the source and chemical nature of the individual agents.

Supported in part by Veterans Administration Research Fund.

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Zimmerman, H.J. (1976). Experimental Hepatotoxicity. In: Eichler, O. (eds) Experimental Production of Diseases. Handbook of Experimental Pharmacology / Handbuch der experimentellen Pharmakologie, vol 16 / 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-45483-7_1

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  • DOI: https://doi.org/10.1007/978-3-642-45483-7_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-45485-1

  • Online ISBN: 978-3-642-45483-7

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