Competitive Neuromuscular Blocking Drugs

  • Jennifer Maclagan
Part of the Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology book series (HEP, volume 42)


The first neuromuscular blocking drug to be introduced into general anaesthetic use was tubocurarine (Griffith and Johnson, 1942). In man, a single intravenous injection of a dose which caused adequate relaxation of the abdominal muscles, produced paralysis lasting for 30 to 40 min. This proved to be unduly long for convenient use during anaesthesia and the search began for neuromuscular blocking drugs with a shorter duration of action.


Histamine Release Neuromuscular Junction Soleus Muscle Neuromuscular Blockade Neuromuscular Blocking 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin · Heidelberg 1976

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  • Jennifer Maclagan

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