Abstract
This chapter is concerned with the metabolism of acetylcholine (ACh) at synapses where it functions as the neurotransmitter. The vertebrate neuromuscular junction has been studied more closely than any other synapse, but most of the studies have made use of biophysical or morphological techniques rather than biochemical ones; relatively few investigators have attempted to measure the ACh content of skeletal muscle, or the rate of its release or its synthesis. For such neurochemical experiments other tissues, especially the brain, sympathetic ganglia and the electric organ, are generally chosen. These tissues are much richer in cholinergic synapses, and therefore in ACh, so the technical difficulties of estimating submicrogram amounts of ACh are less formidable. Each of the three tissues provides advantages for particular types of experiment, and together they have furnished most of the available neurochemical data. There is now, however, both direct and indirect evidence that ACh metabolism in muscle is similar in many respects to ACh metabolism in the tissues in which it has been studied in more detail. With this justification, a great deal of information obtained from tissues other than muscle will be discussed in this chapter.
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MacIntosh, F.C., Collier, B. (1976). Neurochemistry of Cholinergic Terminals. In: Zaimis, E., Maclagan, J. (eds) Neuromuscular Junction. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 42. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-45476-9_3
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