Skip to main content

Schizophrenia and Addiction

  • Chapter
  • First Online:
Co-occurring Addictive and Psychiatric Disorders

Abstract

Substance use disorders are highly prevalent among people with schizophrenia. Dually diagnosed patients present with unfavorable course and poor long-term outcomes. Integrated, motivation-based treatment for both disorders in the same setting is considered the treatment of choice for this challenging population. Treatment programs include state-of-the-art pharmacotherapy and psychosocial interventions such as motivational interviewing, psychoeducation, and cognitive–behavioral approaches.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Bechdolf A, Pohlmann B, GĂĽttgemanns J et al (2012) State-dependent motivational interviewing for people with schizophrenia and substance use: results of a randomised controlled trial. Nervenarzt 83:888–896

    Article  CAS  PubMed  Google Scholar 

  • Bennett ME, Bellack AS, Gearon JS (2001) Treating substance abuse in schizophrenia. An initial report. J Subst Abuse Treat 20:163–175

    Article  CAS  PubMed  Google Scholar 

  • Blanchard JJ, Brown SA, Horan WP, Sherwood AR (2000) Substance use disorders in schizophrenia: review, integration, and a proposed model. Clin Psychol Rev 20:207–234

    Article  CAS  PubMed  Google Scholar 

  • Borgwardt SJ, Riecher-Rossler A, Dazzan P (2007) Regional gray matter volume abnormalities in the at risk mental state. Biol Psychiatry 61:1148–1156

    Article  PubMed  Google Scholar 

  • Cassidy CM, Schmitz N, Malla A (2008) Validation of the alcohol use disorders identification test and the drug abuse screening test in first episode psychosis. Can J Psychiatry 53:26–33

    PubMed  Google Scholar 

  • Chambers RA, Krystal JH, Self DW (2001) A neurobiological basis for substance abuse comorbidity in schizophrenia. Biol Psychiatry 50:71–83

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Cleary M, Hunt GE, Matheson SL, Siegfried N, Walter G (2010) Psychosocial interventions for people with both severe mental illness and substance misuse. The Cochrane Collaboration. Editorial Group: Cochrane Schizophrenia Group. Wiley

    Google Scholar 

  • D’Amelio R, Behrendt BWT (2007) Psychoedukation Schizophrenie und Sucht. Manual zur Leitung von Patienten-und Angehörigengruppen. Elsevier/Urban and Fischer, Munich

    Google Scholar 

  • De Witte NA, Crunelle CL, Sabbe B, Moggi F, Dom G (2013) Treatment for outpatients with comorbid schizophrenia and substance use disorders: a review. Eur Addict Res 20:105–114

    Article  PubMed  Google Scholar 

  • Drake RE, Mueser KT (2000) Psychosocial approaches to dual diagnosis. Schizophr Bull 26:105–118

    Article  CAS  PubMed  Google Scholar 

  • Drake RE, Mueser KT, Brunette MF, McHugo GJ (2004) A review of treatments for people with severe mental illnesses and co-occurring substance use disorders. Psychiatr Rehabil J 27:360–374

    Article  PubMed  Google Scholar 

  • Drake RE, O’Neal EL, Wallach MA (2008) A systematic review of psychosocial research on psychosocial interventions for people with co-occurring severe mental and substance use disorders. J Subst Abuse Treat 34:123–138

    Article  PubMed  Google Scholar 

  • Duke PJ, Pantelis C, McPhillips MA, Barnes TRE (2001) Comorbid non-alcohol substance misuse among people with schizophrenia. Br J Psychiatry 179:509–513

    Article  CAS  PubMed  Google Scholar 

  • Gouzoulis-Mayfrank E (2007) Komorbidität Psychose und Sucht—Grundlagen und Praxis—Mit Manualen fĂĽr die Psychoedukation und Verhaltenstherapie, 2nd edn. Steinkopff, Darmstadt

    Google Scholar 

  • Green AI, Noordsy DL, Brunette MF, O’Keefe C (2008) Substance abuse and schizophrenia: pharmacotherapeutic intervention. J Subst Abuse Treat 34:61–71

    Article  PubMed Central  PubMed  Google Scholar 

  • Lazary J (2012) Psychopharmacological boundaries of schizophrenia with comorbid cannabis use disorder: a critical review. Curr Pharm Des 18:4890–4896

    Article  CAS  PubMed  Google Scholar 

  • Lowe AL, Abou-Saleh MT (2004) The British experience of dual diagnosis in the national health service. Acta Neuropsychiatrica 16:41–46

    Article  Google Scholar 

  • Moggi F, Brodbeck J, Költzsch K, Hirsbrunner H-P, Bachmann KM (2002) One-year follow-up of dual diagnosis patients attending a 4-month integrated inpatient treatment. Eur Addict Res 8:30–37

    Article  PubMed  Google Scholar 

  • Moore TH, Zammit S, Lingford-Hughes A et al (2007) Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review. Lancet 370:319–328

    Article  PubMed  Google Scholar 

  • Morrens M, Dewilde B, Sabbe B, Dom G, De Cuyper R, Moggi F (2011) Treatment Outcomes of an Integrated Residential Programme for patients with schizophrenia and substance use disorder. Eur Addict Res 17:154–163

    Article  PubMed  Google Scholar 

  • Mueser KT, Fox L (2002) A family intervention program for dual disorders. Community Ment Health J 38:253–270

    Article  PubMed  Google Scholar 

  • Mueser KT, Drake RE, Wallach MA (1998) Dual diagnosis: a review of etiological theories. Addict Behav 23:717–734

    Article  CAS  PubMed  Google Scholar 

  • Mueser KT, Yarnold PR, Rosenberg SD, Swett C Jr, Miles KM, Hill D (2000) Substance use disorder in hospitalized severely mentally ill psychiatric patients: prevalence, correlates, and subgroups. Schizophr Bull 26:179–192

    Article  CAS  PubMed  Google Scholar 

  • Petrakis IL, Poling J, Levinson C, Nich C, Carroll K, Rounsaville B (2005) Naltrexone and disulfiram in patients with alcohol dependence and comorbid psychiatric disorders. Biol Psychiatry 57:1128–1137

    Article  CAS  PubMed  Google Scholar 

  • Ralevski E, O’Brien E, Jane S, Dean E, Dwan R, Petrakis I (2011) Effects of acamprosate in a treatment study of patients with schizophrenia spectrum disorders and comorbid alcohol dependence. J Nerv Mental Dis 199:499–505

    Article  Google Scholar 

  • Regier DA, Farmer ME, Rae DS et al (1990) Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study. JAMA 264:2511–2518

    Article  CAS  PubMed  Google Scholar 

  • Rubio G, MartĂ­nez I, Ponce G, JimĂ©nez-Arriero MA, LĂłpez-Muñoz F, Alamo C (2006) Long-acting injectable risperidone compared with zuclopenthixol in the treatment of schizophrenia with substance abuse comorbidity. Can J Psychiatry 51:531–539

    PubMed  Google Scholar 

  • Schnell T, Koethe D, Krasnianski A, Gairing S, Schnell K, Daumann J, Gouzoulis-Mayfrank E (2014) Ziprasidone versus clozapine in the treatment of dually diagnosed (DD) patients with schizophrenia and cannabis use disorders: a randomized study. Am J Addict 23:308–312

    Article  PubMed  Google Scholar 

  • Sinha R, Garcia M, Paliwal P, Kreek MJ, Rounsaville BJ (2006) Stress-induced cocaine craving and hypothalamic-pituitary-adrenal responses are predictive of cocaine relapse outcome. Arch Gen Psychiatry 63:324–331

    Article  PubMed  Google Scholar 

  • Volkow ND, Wang GJ, Fowler JS, Tomasi D, Telang F (2011) Addiction: beyond dopamine reward circuitry. Proc Natl Acad Sci U S A 108:15037–15042

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Walter M, Denier N, Vogel M, Lang UE (2012) Effects of psychoactive substances in schizophrenia. Curr Top Med Chem 12:2426–2433

    Article  CAS  PubMed  Google Scholar 

  • Walter M, Gerber H, Kuhl HC et al (2013) Acute effects of intravenous diacetylmorphine on the hypothalamic-pituitary-adrenal axis response. J Clin Psychopharmacol 33:193–198

    Article  CAS  PubMed  Google Scholar 

  • Wright IC, Rabe-Hesketh S, Woodruff PW, David AS, Murray RM, Bullmore ET (2000) Meta-analysis of regional brain volumes in schizophrenia. Am J Psychiatry 157:16–25

    CAS  PubMed  Google Scholar 

  • Ziedonis DM, D’Avanzo K (1998) Schizophrenia and substance abuse. In: Kranzler HR, Rounsaville BJ (eds) Dual diagnosis and treatment. Marcel Dekker, New York, pp 427–465

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Euphrosyne Gouzoulis-Mayfrank .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Gouzoulis-Mayfrank, E., Walter, M. (2015). Schizophrenia and Addiction. In: Dom, G., Moggi, F. (eds) Co-occurring Addictive and Psychiatric Disorders. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-45375-5_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-45375-5_6

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-45374-8

  • Online ISBN: 978-3-642-45375-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics