Abstract
Dual disorder patients are characterized by a highly variable and phenotypically complex presentation. Recent research suggests that impairments within a limited number of functional neurobiological dimensions may play a central role in the vulnerability for development of dual disorders. Specifically impairments in the central regulatory role of the hippocampus and brain circuitries underlying behavioural control and stress regulation may be proposed as “trans-disease”, i.e. processes that occur across a range of disorders, making findings from one disorder relevant to the other disorders. This line of thinking may open up new ways of exploring not only the pathogenesis of dual disorders, but most importantly, may provide new targets for both treatment and prevention interventions for these patients.
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References
Andersen SL, Teicher MH (2009) Desperately driven and no brakes: developmental stress exposure and subsequent risk for substance abuse. Neurosci Biobehav Rev 33(4):516–524. doi:10.1016/j.neubiorev.2008.09.009
Ansell EB, Gu P, Tuit K, Sinha R (2012a) Effects of cumulative stress and impulsivity on smoking status. Hum Psychopharmacol 27(2):200–208. doi:10.1002/hup.1269
Ansell EB, Rando K, Tuit K, Guarnaccia J, Sinha R (2012b) Cumulative adversity and smaller gray matter volume in medial prefrontal, anterior cingulate, and insula regions. Biol Psychiatry 72(1):57–64. doi:10.1016/j.biopsych.2011.11.022
Benjet C, Borges G, Medina-Mora ME, Mendez E (2013) Chronic childhood adversity and stages of substance use involvement in adolescents. Drug Alcohol Depend 131(1–2):85–91. doi:10.1016/j.drugalcdep.2012.12.002
Bickel WK, Mueller ET (2009) Toward the Study of Trans-Disease Processes: a novel approach with special reference to the study of co-morbidity. J Dual Diagn 5(2):131–138. doi:10.1080/15504260902869147
Brazil IA, de Bruijn ER, Bulten BH, von Borries AK, van Lankveld JJ, Buitelaar JK, Verkes RJ (2009) Early and late components of error monitoring in violent offenders with psychopathy. Biol Psychiatry 65(2):137–143. doi:10.1016/j.biopsych.2008.08.011
Chambers RA (2007) Animal modeling and neurocircuitry of dual diagnosis. J Dual Diagn 3(2):19–29. doi:10.1300/J374v03n02_04
Chambers RA (2013) Adult hippocampal neurogenesis in the pathogenesis of addiction and dual diagnosis disorders. Drug Alcohol Depend 130(1–3):1–12. doi:10.1016/j.drugalcdep.2012.12.005
Connolly CG, Foxe JJ, Nierenberg J, Shpaner M, Garavan H (2012) The neurobiology of cognitive control in successful cocaine abstinence. Drug Alcohol Depend 121(1–2):45–53. doi:10.1016/j.drugalcdep.2011.08.007
Cuthbert BN (2014) The RDoC framework: facilitating transition from ICD/DSM to dimensional approaches that integrate neuroscience and psychopathology. World Psychiatry 13(1):28–35. doi:10.1002/wps.20087
de Bruijn ER, Grootens KP, Verkes RJ, Buchholz V, Hummelen JW, Hulstijn W (2006) Neural correlates of impulsive responding in borderline personality disorder: ERP evidence for reduced action monitoring. J Psychiatr Res 40(5):428–437. doi:10.1016/j.jpsychires.2005.09.004
De Wilde B, Verdejo-Garcia A, Sabbe B, Hulstijn W, Dom G (2013) Affective decision-making is predictive of three-month relapse in polysubstance-dependent alcoholics. Eur Addict Res 19(1):21–28. doi:10.1159/000339290
Dom G, De Wilde B, Hulstijn W, van den Brink W, Sabbe B (2006) Decision-making deficits in alcohol-dependent patients with and without comorbid personality disorder. Alcohol Clin Exp Res 30(10):1670–1677. doi:10.1111/j.1530-0277.2006.00202.x
Goldstein RZ, Volkow ND (2011) Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications. Nat Rev Neurosci 12(11):652–669. doi:10.1038/nrn3119
Jakubczyk A, Klimkiewicz A, Mika K, Bugaj M, Konopa A, Podgorska A, Wojnar M (2013) Psychosocial predictors of impulsivity in alcohol-dependent patients. J Nerv Ment Dis 201(1):43–47. doi:10.1097/NMD.0b013e31827aaf9d
Jakubczyk A, Klimkiewicz A, Topolewska-Wochowska A, Serafin P, Sadowska-Mazuryk J, Pupek-Pyziol J, Wojnar M (2012) Relationships of impulsiveness and depressive symptoms in alcohol dependence. J Affect Disord 136(3):841–847. doi:10.1016/j.jad.2011.09.028
Jurado-Barba R, Morales-Munoz I, Del Manzano BA, Fernandez-Guinea S, Caballero M, Martinez-Gras I, Rubio-Valladolid G (2011) Relationship between measures of inhibitory processes in patients with schizophrenia: role of substance abuse disorders. Psychiatry Res 190(2–3):187–192. doi:10.1016/j.psychres.2011.06.002
Kessler RC (2004) The epidemiology of dual diagnosis. Biol Psychiatry 56(10):730–737. doi:10.1016/j.biopsych.2004.06.034
Kessler RC, Petukhova M, Zaslavsky AM (2011) The role of latent internalizing and externalizing predispositions in accounting for the development of comorbidity among common mental disorders. Curr Opin Psychiatry 24(4):307–312. doi:10.1097/YCO.0b013e3283477b22
Lovallo WR (2013) Early life adversity reduces stress reactivity and enhances impulsive behavior: implications for health behaviors. Int J Psychophysiol 90(1):8–16. doi:10.1016/j.ijpsycho.2012.10.006
McEwen BS (2000) The neurobiology of stress: from serendipity to clinical relevance. Brain Res 886(1–2):172–189
McLaughlin KA, Greif Green J, Gruber MJ, Sampson NA, Zaslavsky AM, Kessler RC (2012) Childhood adversities and first onset of psychiatric disorders in a national sample of US adolescents. Arch Gen Psychiatry 69(11):1151–1160. doi:10.1001/archgenpsychiatry.2011.2277
Moggi F (2005) Etiological theories on the relationship of mental disorders and substance use disorders. In: Stohler R, Rossler W (eds) Dual Diagnosis. The evolving conceptual framework, vol 172, Bilblotheca Psychiatrica. Karger, Basel, pp 1–14
Morein-Zamir S, Simon Jones P, Bullmore ET, Robbins TW, Ersche KD (2013) Prefrontal hypoactivity associated with impaired inhibition in stimulant-dependent individuals but evidence for hyperactivation in their unaffected siblings. Neuropsychopharmacology 38(10):1945–1953. doi:10.1038/npp.2013.90
Noonan MA, Bulin SE, Fuller DC, Eisch AJ (2010) Reduction of adult hippocampal neurogenesis confers vulnerability in an animal model of cocaine addiction. J Neurosci 30(1):304–315. doi:10.1523/JNEUROSCI.4256-09.2010
Paulus MP, Tapert SF, Schuckit MA (2005) Neural activation patterns of methamphetamine-dependent subjects during decision making predict relapse. Arch Gen Psychiatry 62(7):761–768. doi:10.1001/archpsyc.62.7.761
Reissner V, Kokkevi A, Schifano F, Room R, Storbjork J, Stohler R, Scherbaum N (2012) Differences in drug consumption, comorbidity and health service use of opioid addicts across six European urban regions (TREAT-project). Eur Psychiatry 27(6):455–462. doi:10.1016/j.eurpsy.2010.10.001
Scheller-Gilkey G, Moynes K, Cooper I, Kant C, Miller AH (2004) Early life stress and PTSD symptoms in patients with comorbid schizophrenia and substance abuse. Schizophr Res 69(2–3):167–174
Shiels K, Hawk LW Jr (2010) Self-regulation in ADHD: the role of error processing. Clin Psychol Rev 30(8):951–961. doi:10.1016/j.cpr.2010.06.010
Sinha R (2011) New findings on biological factors predicting addiction relapse vulnerability. Curr Psychiatry Rep 13(5):398–405. doi:10.1007/s11920-011-0224-0
Stevens L, Verdejo-Garcia A, Goudriaan AE, Roeyers H, Dom G, Vanderplasschen W (2014) Impulsivity as a vulnerability factor for poor addiction treatment outcomes: a review of neurocognitive findings among individuals with substance use disorders. J Subst Abuse Treat 47(1):58–72. doi:10.1016/j.jsat.2014.01.008
Tarter RE, Kirisci L, Mezzich A, Cornelius JR, Pajer K, Vanyukov M, Clark D (2003) Neurobehavioral disinhibition in childhood predicts early age at onset of substance use disorder. Am J Psychiatry 160(6):1078–1085
Vanyukov MM, Tarter RE, Kirillova GP, Kirisci L, Reynolds MD, Kreek MJ, Ridenour TA (2012) Common liability to addiction and “gateway hypothesis”: theoretical, empirical and evolutionary perspective. Drug Alcohol Depend 123(Suppl 1):S3–S17. doi:10.1016/j.drugalcdep.2011.12.018
Volkow ND, Baler RD (2014) Addiction science: uncovering neurobiological complexity. Neuropharmacology 76(Pt B):235–249. doi:10.1016/j.neuropharm.2013.05.007
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Dom, G., Wojnar, M. (2015). The Pathogenesis of Dual Disorders: Neurobiological Perspectives. In: Dom, G., Moggi, F. (eds) Co-occurring Addictive and Psychiatric Disorders. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-45375-5_5
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DOI: https://doi.org/10.1007/978-3-642-45375-5_5
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