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High-Throughput Technologies in Molecular Biology

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Part of the book series: Lecture Notes in Computer Science ((LNBI,volume 8248))

Abstract

Over the past few decades, advances in the computer science and informatics have made possible development of new strategies in molecular biology that enable to collect and analyze the data about complex interactions within biological systems. A new inter-disciplinary field of study, called systems biology, has been created. It analyzes and integrates information from genomics (DNA level), transcriptomics (RNA level), proteomics (protein level) and other related fields (e.g. metabolomics and other -omics). Specialized tools to view and analyze biological data and computerized databases to store, organize, and index the data are required. Thus, bioinformatics, the interface between the biological and computational sciences, is indispensable to obtain a clearer insight into the fundamental biology of organisms.

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References

  1. Bednár, M.: DNA microarray technology and application. Medical Science Monitor 6, 796–800 (2000)

    Google Scholar 

  2. Duncan, M.W., Roder, H., Hunsucker, S.W.: Quantitative matrix-assisted laser desorption/ionization mass spectrometry. Brief Funct Genomic Proteomic 7, 355–370 (2008)

    Article  Google Scholar 

  3. Hacia, J.G., Collins, F.S.: Mutational analysis using oligonucleotide microarrays. Journal of Medical Genetics 36, 730–736 (1999)

    Article  Google Scholar 

  4. Hoffman, B.G., Jones, S.J.M.: Identification of DNA-protein interactions. Journal of Endocrinology 201, 1–13 (2009)

    Article  Google Scholar 

  5. Jamesdaniel, S., Salvi, R., Coling, D.: Auditory proteomics: methods, accomplishments and challenges. Brain Research 1277, 24–36 (2009)

    Article  Google Scholar 

  6. Mardis, E.R.: Anticipating the 1,000 dollar genome. Genome Biology 7, 112 (2006)

    Article  Google Scholar 

  7. Murphy, D.: Gene expression studies using microarrays: principles, problems, and prospects. Advances in Physiology Education 26, 256–270 (2002)

    Google Scholar 

  8. Pareek, C.S., Smoczynski, R., Tretyn, A.: Sequencing technologies and genome sequencing. Journal of Applied Genetics 52, 413–435 (2011)

    Article  Google Scholar 

  9. Park, P.J.: ChIP-seq: advantages and challenges of a maturing technology. Nature Reviews Genetics 10, 669–680 (2009)

    Article  Google Scholar 

  10. Ragoussis, J., Elvidge, G.P., Kaur, K., Colella, S.: Matrix-assisted laser desorption/ionisation, time-of-flight mass spectrometry in genomics research. PLoS Genetics 2, e100 (2006)

    Google Scholar 

  11. Roth, C.M.: Quantifying gene expression. Current Issues of Molecular Biology 4, 93–100 (2002)

    Google Scholar 

  12. Schadt, E.E., Turner, S., Kasarskis, A.: A window into third-generation sequencing. Human Molecular Genetics 19(R2), R227–R240 (2010)

    Google Scholar 

  13. Thompson, J.F., Milos, P.M.: The properties and applications of single-molecule DNA sequencing. Genome Biology 12, 217 (2011)

    Google Scholar 

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© 2013 Springer-Verlag Berlin Heidelberg

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Widłak, W. (2013). High-Throughput Technologies in Molecular Biology. In: Widłak, W. (eds) Molecular Biology. Lecture Notes in Computer Science(), vol 8248. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-45361-8_9

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  • DOI: https://doi.org/10.1007/978-3-642-45361-8_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-45360-1

  • Online ISBN: 978-3-642-45361-8

  • eBook Packages: Computer ScienceComputer Science (R0)

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