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Transcriptional and Epigenetic Regulation in the Development of Myeloid Cells: Normal and Diseased Myelopoiesis

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Book cover Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development

Part of the book series: Epigenetics and Human Health ((EHH))

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Abstract

Myeloid cells constitute the innate arm of the vertebrate immune system and arise from haematopoietic stem cells being committed to their cell fate through a series of lineage restrictions regulated by a gene regulatory network. This gene network consists of transcription factors as well as components of the epigenetic machinery that, in cooperation with one another, will programme progenitors to adopt and differentiate along a certain lineage programme. By virtue of their obligatory function, dysregulation in the activity of these regulatory factors can contribute to the pathogenesis of myeloid leukaemias. To understand the molecular aetiology of myeloid dysplasias it is imperative to first study and model the network that regulates normal development. Equipped with this crucial understanding we can then begin to decipher what, how and why things have gone wrong in the pathology of myeloid leukaemias.

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Acknowledgements

We apologise to the many authors whose work we could not cite owing to space constraints. This work was supported by grants from Leukaemia and Lymphoma Research (PL), Royal Society (PL), Grant Agency of the Czech Republic # P305/12/1033 (TS) Institutional (TS): Charles University: UNCE 204021, First Medical Faculty: PRVOUK-P24/LF1/3 & SVV-2013-264507, BIOCEV—Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University (CZ.1.05/1.1.00/02.0109), from the European Regional Development Fund.

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  1. Section of Experimental Haematology, Leeds Institute of Cancer and Pathology, St. James’s University Hospital, University of Leeds, Leeds, UK

    Peter Laslo

  2. Institute of Pathophysiology and First Department of Medicine-Haematology, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic

    Tomas Stopka

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  1. Peter Laslo
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Correspondence to Peter Laslo .

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  1. Institute of Biomedical Research, University of Birmingham Medical and Dental Sciences, Birmingham, United Kingdom

    Constanze Bonifer

  2. Institute of Biomedical Research, University of Birmingham Medical and Dental Sciences, Birmingham, United Kingdom

    Peter N. Cockerill

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Laslo, P., Stopka, T. (2014). Transcriptional and Epigenetic Regulation in the Development of Myeloid Cells: Normal and Diseased Myelopoiesis. In: Bonifer, C., Cockerill, P. (eds) Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development. Epigenetics and Human Health. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-45198-0_9

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