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Chemoprevention of Prostate Cancer by Isoflavonoids

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Prostate Cancer Prevention

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 202))

Abstract

In Europe, prostate cancer (PC) is the most common malignancy in males. There are three known risk factors strongly coherent to the development of PC: heredity, ethnical origin, and age. Migration studies have shown that environmental factors may influence the development of PC. In this context, specific nutritional components may exert an influence on the tumorigenesis of PC. Primary prevention of PC is still an important issue due to its high prevalence, treatment-associated morbidities, and long-term complications. Phytoestrogenes as flavonoids seem to play an essential role in the chemoprevention of PC which is possibly due to their hormonal function and antioxidative capability. Flavonoids and their subgroups are naturally existent in traditional asian and vegetarian nutrients as coverings of plants, fruits, and vegetables. Two of the most frequently investigated flavonoids are genistein and quercetin. These nutritional components may have therapeutic potential and may impact the development of PC. Even though these flavonoids show promising results in the chemoprevention of PC, the literature is almost experimental, epidemiological, and retrospective with a missing long-term follow-up. Therefore, randomized clinical trials are urgently needed to evaluate in depth its oncologic effects in PC.

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References

  • Aalinkeel R, Hu Z, Nair BB et al (2010) Genomic analysis highlights the role of the JAK-STAT signaling in the anti-proliferative effects of dietary flavonoid-‘ashwagandha’ in prostate cancer cells. J Evid Based Complementary Altern Med 7:177–187

    Article  Google Scholar 

  • Adams KF, Chen C, Newton KM, Potter JD, Lampe JW (2004) Soy isoflavones do not modulate prostate-specific antigen concentrations in older men in a randomized controlled trial. Cancer Epidemiol Biomarkers Prev 13:644–648

    CAS  PubMed  Google Scholar 

  • Banerjee S, Li Y, Wang Z, Sarkar FH (2008) Multi-targeted therapy of cancer by genistein. Cancer Lett 269:226–242

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Barnes S (1995) Effect of genistein on in vitro and in vivo models of cancer. J Nutr 125:777S–783S

    CAS  PubMed  Google Scholar 

  • Bischoff SC (2008) Quercetin: potentials in the prevention and therapy of disease. Curr Opin Clin Nutr Metab Care 11:733–740

    Article  CAS  PubMed  Google Scholar 

  • Boyle P, Ferlay J (2005) Cancer incidence and mortality in Europe, 2004. Ann Oncol 16:481–488

    Article  CAS  PubMed  Google Scholar 

  • Butler LM, Wong AS, Koh WP, Wang R, Yuan JM, Yu MC (2010) Calcium intake increases risk of prostate cancer among Singapore Chinese. Cancer Res 70:4941–4948

    Article  CAS  PubMed  Google Scholar 

  • Cheng S, Balk SP (2003) Steroid hormone receptor signaling in cancer. Cancer Treat Res 115:293–318

    Article  CAS  PubMed  Google Scholar 

  • Cimino S, Sortino G, Favilla V et al (2012) Polyphenols: key issues involved in chemoprevention of prostate cancer. Oxid Med Cell Longev 2012:632959

    Article  PubMed Central  PubMed  Google Scholar 

  • Czaplinska M, Czepas J, Gwozdzinski K (2012) Structure, antioxidative and anticancer properties of flavonoids. Postepy biochemii 58:235–244

    Google Scholar 

  • Dalais FS, Meliala A, Wattanapenpaiboon N et al (2004) Effects of a diet rich in phytoestrogens on prostate-specific antigen and sex hormones in men diagnosed with prostate cancer. Urology 64:510–515

    Article  PubMed  Google Scholar 

  • deVere White RW, Tsodikov A, Stapp EC, Soares SE, Fujii H, Hackman RM (2010) Effects of a high dose, aglycone-rich soy extract on prostate-specific antigen and serum isoflavone concentrations in men with localized prostate cancer. Nutr Cancer 62:1036–1043

    Google Scholar 

  • Egert S, Wolffram S, Bosy-Westphal A et al (2008) Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans. J Nutr 138:1615–1621

    CAS  PubMed  Google Scholar 

  • Ferris-Tortajada J, Berbel-Tornero O, Garcia-Castell J, Ortega-Garcia JA, Lopez-Andreu JA (2012) Dietetic factors associated with prostate cancer: protective effects of Mediterranean diet. Actas urologicas espanolas 36:239–245

    Google Scholar 

  • Gardner CD, Oelrich B, Liu JP, Feldman D, Franke AA, Brooks JD (2009) Prostatic soy isoflavone concentrations exceed serum levels after dietary supplementation. Prostate 69:719–726

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Gibellini L, Pinti M, Nasi M et al (2011) Quercetin and cancer chemoprevention. J Evid Based Complementary Altern Med 2011:591356

    Google Scholar 

  • Hussain M, Banerjee M, Sarkar FH et al (2003) Soy isoflavones in the treatment of prostate cancer. Nutr Cancer 47:111–117

    Article  CAS  PubMed  Google Scholar 

  • Jemal A, Siegel R, Ward E et al (2008) Cancer statistics. CA Cancer J Clin 58:71–96

    Article  PubMed  Google Scholar 

  • Jenster G (1999) The role of the androgen receptor in the development and progression of prostate cancer. Semin Oncol 26:407–421

    CAS  PubMed  Google Scholar 

  • Jin F, Nieman DC, Shanely RA, Knab AM, Austin MD, Sha W (2010) The variable plasma quercetin response to 12-week quercetin supplementation in humans. Eur J Clin Nutr 64:692–697

    Article  CAS  PubMed  Google Scholar 

  • Key TJ, Appleby PN, Spencer EA et al (2009a) Cancer incidence in British vegetarians. Br J Cancer 101:192−197

    Google Scholar 

  • Key TJ, Appleby PN, Spencer EA, Travis RC, Roddam AW, Allen NE (2009b) Cancer incidence in vegetarians: results from the European Prospective Investigation into Cancer and Nutrition (EPIC-Oxford). American J Clin Nutr 89:1620S−1626S

    Google Scholar 

  • Kumar NB, Cantor A, Allen K et al (2004) The specific role of isoflavones in reducing prostate cancer risk. Prostate 59:141–147

    Article  CAS  PubMed  Google Scholar 

  • Kumar NB, Krischer JP, Allen K et al (2007) Safety of purified isoflavones in men with clinically localized prostate cancer. Nutr Cancer 59:169–175

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Lazarevic B, Boezelijn G, Diep LM et al (2011) Efficacy and safety of short-term genistein intervention in patients with localized prostate cancer prior to radical prostatectomy: a randomized, placebo-controlled, double-blind Phase 2 clinical trial. Nutr Cancer 63:889–898

    Article  CAS  PubMed  Google Scholar 

  • Lee DH, Szczepanski M, Lee YJ (2008) Role of Bax in quercetin-induced apoptosis in human prostate cancer cells. Biochem Pharmacol 75:2345–2355

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Liu RH (2013) Health-promoting components of fruits and vegetables in the diet. Adv Nutr 4:384S–392S

    Article  CAS  PubMed  Google Scholar 

  • Magee PJ, Rowland IR (2004) Phyto-oestrogens, their mechanism of action: current evidence for a role in breast and prostate cancer. Br J Nutr 91:513–531

    Article  CAS  PubMed  Google Scholar 

  • Maskarinec G, Morimoto Y, Hebshi S, Sharma S, Franke AA, Stanczyk FZ (2006) Serum prostate-specific antigen but not testosterone levels decrease in a randomized soy intervention among men. Eur J Clin Nutr 60:1423–1429

    Article  CAS  PubMed  Google Scholar 

  • McCann SE, Ambrosone CB, Moysich KB et al (2005) Intakes of selected nutrients, foods, and phytochemicals and prostate cancer risk in western New York. Nutr Cancer 53:33–41

    Article  CAS  PubMed  Google Scholar 

  • Miyanaga N, Akaza H, Hinotsu S et al (2012) Prostate cancer chemoprevention study: an investigative randomized control study using purified isoflavones in men with rising prostate-specific antigen. Cancer Sci 103:125–130

    Article  CAS  PubMed  Google Scholar 

  • National Cancer Institute (1996) Clinical development plan: genistein. J Cell Biochem Suppl 26:114–126

    Google Scholar 

  • Pendleton JM, Tan WW, Anai S et al (2008) Phase II trial of isoflavone in prostate-specific antigen recurrent prostate cancer after previous local therapy. BMC Cancer 8:132

    Article  PubMed Central  PubMed  Google Scholar 

  • Perabo FG, Von Low EC, Ellinger J, von Rucker A, Muller SC, Bastian PJ (2008) Soy isoflavone genistein in prevention and treatment of prostate cancer. Prostate Cancer Prostatic Dis 11:6–12

    Article  CAS  PubMed  Google Scholar 

  • Schroder FH, Roobol MJ, Boeve ER et al (2005) Randomized, double-blind, placebo-controlled crossover study in men with prostate cancer and rising PSA: effectiveness of a dietary supplement. Eur Urol 48:922–930; discussion 30-1

    Google Scholar 

  • Schultz C, Meier M, Schmid HP (2011) Nutrition, dietary supplements and adenocarcinoma of the prostate. Maturitas 70:339–342

    Article  CAS  PubMed  Google Scholar 

  • Tang SN, Singh C, Nall D, Meeker D, Shankar S, Srivastava RK (2010) The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition. J Mol Signaling 5:14

    Article  Google Scholar 

  • Tarkowski M, Kokocinska M, Latocha M (2013) Genistein in chemoprevention and treatment. Polski merkuriusz lekarski: organ Polskiego Towarzystwa Lekarskiego 34:54–57

    Google Scholar 

  • Travis RC, Spencer EA, Allen NE et al (2009) Plasma phyto-oestrogens and prostate cancer in the European prospective investigation into cancer and nutrition. Br J Cancer 100:1817–1823

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Travis RC, Allen NE, Appleby PN et al (2012) Prediagnostic concentrations of plasma genistein and prostate cancer risk in 1,605 men with prostate cancer and 1,697 matched control participants in EPIC. Cancer Causes Control 23:1163–1171

    Article  PubMed Central  PubMed  Google Scholar 

  • Vijayababu MR, Kanagaraj P, Arunkumar A, Ilangovan R, Aruldhas MM, Arunakaran J (2005) Quercetin-induced growth inhibition and cell death in prostatic carcinoma cells (PC-3) are associated with increase in p21 and hypophosphorylated retinoblastoma proteins expression. J Cancer Res Clin Oncol 131:765–771

    Article  CAS  PubMed  Google Scholar 

  • Vijayababu MR, Arunkumar A, Kanagaraj P, Venkataraman P, Krishnamoorthy G, Arunakaran J (2006) Quercetin downregulates matrix metalloproteinases 2 and 9 proteins expression in prostate cancer cells (PC-3). Mol Cell Biochem 287:109–116

    Article  CAS  PubMed  Google Scholar 

  • Williamson G, Manach C (2005) Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies. American J Clin Nutr 81:243S–255S

    CAS  Google Scholar 

  • Zhao R, Xiang N, Domann FE, Zhong W (2009) Effects of selenite and genistein on G2/M cell cycle arrest and apoptosis in human prostate cancer cells. Nutr Cancer 61:397–407

    Article  CAS  PubMed Central  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Urology, Eberhard-Karls University, Tübingen, Germany

    Stefan Aufderklamm, Florian Miller, Arnulf Stenzl & Georgios Gakis

  2. Institute of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany

    Anastasia Galasso

Authors
  1. Stefan Aufderklamm
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  2. Florian Miller
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  3. Anastasia Galasso
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  4. Arnulf Stenzl
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  5. Georgios Gakis
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Corresponding author

Correspondence to Stefan Aufderklamm .

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Editors and Affiliations

  1. Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine Queen Mary University of London, London, United Kingdom

    Jack Cuzick

  2. Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine Queen Mary University of London, London, United Kingdom

    Mangesh A. Thorat

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Aufderklamm, S., Miller, F., Galasso, A., Stenzl, A., Gakis, G. (2014). Chemoprevention of Prostate Cancer by Isoflavonoids. In: Cuzick, J., Thorat, M. (eds) Prostate Cancer Prevention. Recent Results in Cancer Research, vol 202. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-45195-9_12

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  • DOI: https://doi.org/10.1007/978-3-642-45195-9_12

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  • Print ISBN: 978-3-642-45194-2

  • Online ISBN: 978-3-642-45195-9

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