Risk Adapted Chemoprevention for Prostate Cancer: An Option?

  • Bernd J. Schmitz-DrägerEmail author
  • Oliver Schöffski
  • Michael Marberger
  • Sevim Sahin
  • Hans-Peter Schmid
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 202)


A high disease prevalence, the presentation in older age, a frequently slowly progressing course of disease, and high costs make diagnosis and therapy of prostate cancer a special challenge for urologists. Effective prevention of the disease may help to resolve some of the problems mentioned above. Two randomised, controlled studies prove that effective chemoprevention of prostate cancer is possible using 5-α reductase inhibitors (finasteride, dutasteride) (LoE 1) both in individuals at low and those at high risk developing prostate cancer. Furthermore, there is evidence that other compounds, e.g. selective estrogen receptor modulators (SERMs), non-steroidal anti-inflammatory drugs (NSAIDs) and statins might also be effective. This review investigates potential risks and benefits of chemoprevention including a consideration of health economic aspects. The authors conclude that chemoprevention in a high risk cohort using 5-α reductase inhibitors is a viable option and may even be cost effective. In consequence, the options of chemoprevention in prostate cancer should be further explored in an open and unbiased way.


Chemoprevention Prostate cancer 5α reductase inhibitors Finasteride Dutasteride Health economy 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Bernd J. Schmitz-Dräger
    • 1
    Email author
  • Oliver Schöffski
    • 2
  • Michael Marberger
    • 3
  • Sevim Sahin
    • 1
  • Hans-Peter Schmid
    • 4
  1. 1.UrologieSchön Klinik Nürnberg/Fürth, Urologie 24FürthGermany
  2. 2.Lehrstuhl für GesundheitsmanagementUniversität Erlangen-NürnbergNürnbergGermany
  3. 3.Department of UrologyMedical University of ViennaViennaAustria
  4. 4.Urologische KlinikKantonsspital St. GallenSt. GallenSwitzerland

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