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PET and SPECT of Neurobiological Systems pp 125–147Cite as

Principles of Brain Perfusion SPECT

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Abstract

Brain perfusion SPECT (single-photon emission computed tomography) is a noninvasive molecular imaging technique in which gamma photons emitted from an injected radioactive tracer allow three-dimensional estimation of regional cerebral blood flow (rCBF). The technique is similar to that of a CT scan, except that the radiation source that is imaged is internal to the patient, thereby allowing for acquisition of functional data. This allows identification of regional hypoperfusion to aid in diagnosis of cerebrovascular disorders and neurologic and neurodegenerative disorders. This chapter describes the technical aspects of performing brain perfusion SPECT, as well as a brief overview of the established clinical and investigational indications for brain perfusion SPECT.

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Authors and Affiliations

  1. Division of Nuclear Medicine, Department of Radiology, University of Washington Medical Center, 1959 NE Pacific Street, 357115, Seattle, WA, 98195-7115, USA

    Shana Elman MD & David H. Lewis MD

Authors
  1. Shana Elman MD
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  2. David H. Lewis MD
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Correspondence to Shana Elman MD .

Editor information

Editors and Affiliations

  1. Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

    Rudi A.J.O. Dierckx

  2. Faculty of Electrical Engineering and Information Technology, University of Applied Sciences Offenburg, Offenburg, Germany

    Andreas Otte

  3. Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

    Erik F.J. de Vries

  4. Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

    Aren van Waarde

  5. Molecular Neurobiology, Universtiy of Groningen, Groningen, The Netherlands

    Paul G.M. Luiten

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Elman, S., Lewis, D.H. (2014). Principles of Brain Perfusion SPECT. In: Dierckx, R., Otte, A., de Vries, E., van Waarde, A., Luiten, P. (eds) PET and SPECT of Neurobiological Systems. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-42014-6_5

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  • DOI: https://doi.org/10.1007/978-3-642-42014-6_5

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-42013-9

  • Online ISBN: 978-3-642-42014-6

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