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Imaging Type 1 Glycine Transporters in the CNS Using Positron Emission Tomography

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PET and SPECT of Neurobiological Systems

Abstract

The type-1 glycine transporter (GlyT1) is a target of interest for the development of new medications for schizophrenia. A specific and selective positron emission tomography (PET) GlyT1 ligand would help understand disease heterogeneity and support drug development studies to determine whether a drug is able to engage this target. During the last 3-4 years, a number of potential ligands have been reported both for preclinical and clinical use. Here, we review the most promising candidates reported to date and make recommendations with regard to their use in clinical studies.

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Author information

Authors and Affiliations

  1. Imanova Limited, Burlington Danes Building, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK

    Jan Passchier & Roger N. Gunn

  2. Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, 9713GZ, The Netherlands

    Aren van Waarde

Authors
  1. Jan Passchier
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  2. Roger N. Gunn
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  3. Aren van Waarde
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Corresponding author

Correspondence to Jan Passchier .

Editor information

Editors and Affiliations

  1. Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

    Rudi A.J.O. Dierckx

  2. Faculty of Electrical Engineering and Information Technology, University of Applied Sciences Offenburg, Offenburg, Germany

    Andreas Otte

  3. Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

    Erik F.J. de Vries

  4. Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

    Aren van Waarde

  5. Molecular Neurobiology, Universtiy of Groningen, Groningen, The Netherlands

    Paul G.M. Luiten

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© 2014 Springer-Verlag Berlin Heidelberg

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Passchier, J., Gunn, R.N., van Waarde, A. (2014). Imaging Type 1 Glycine Transporters in the CNS Using Positron Emission Tomography. In: Dierckx, R., Otte, A., de Vries, E., van Waarde, A., Luiten, P. (eds) PET and SPECT of Neurobiological Systems. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-42014-6_12

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  • DOI: https://doi.org/10.1007/978-3-642-42014-6_12

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-42013-9

  • Online ISBN: 978-3-642-42014-6

  • eBook Packages: MedicineMedicine (R0)

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