Zusammenfassung
Bei der Hepatitis A handelt es sich um eine infektiöse Entzündung der Leber. Der Erreger der Infektion ist das Hepatitis-A-Virus (HAV), ein 27 nm großes, 7,5 kb langes Einzelstrangvirus der Hepadnaviren aus der Familie der Picornaviridiae. HAV ist seit 1973 bekannt (Feinstone et al. 1973); es wurden sieben HAV-Genotypen beschrieben, von denen vier humanpathogen sind (Pischke et al. 2013).
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Literatur
Deterding K, Tegtmeyer B, CornbergMet al (2006) Hepatitis A virus infection suppresses hepatitis C virus replication and may lead to clearance of HCV. J Hepatol 45:770–778
Feinstone SM, Kapikian AZ, Purceli RH (1973) Hepatitis A: detection by immune electron microscopy of a viruslike antigen associated with acute illness. Science 182:1026–1028
Lanford RE, Feng Z, Chavez D et al (2011) Acute hepatitis A virus infection is associated with a limited type I interferon response and persistence of intrahepatic viral RNA. Proc Natl Acad Sci U S A 108: 11223–11228
Manangeeswaran M, Jacques J, Tami C et al (2012) Binding of hepatitis A virus to its cellular receptor 1 inhibits T-regulatory cell functions in humans. Gastroenterology 142(7):1516–25.e3. doi:10.1053/j.gastro.2012.02.039 [Epub 2012 Mar 16]
Ostapowicz G, Fontana RJ, Schiodt FV et al (2002) Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Ann Intern Med 137:947–954
Pischke S, Wedemeyer H (2013) Hepatitis A. In: Hepatology a clinical textbook. Flying Publisher/ Druckhaus Süd, Köln
Schiff ER (1992) Atypical clinical manifestations of Hepatitis A. Vaccine 1992; supplement S18–26
Tseng YT, Chang SY, Liu WC et al (2012) Comparative effectiveness of two doses versus three doses of hepatitis a vaccine in HIV-infected and HIV-uninfected men who have sex with men. Hepatology. doi:10.1002/hep.26210 [Epub vor der Druckversion]
Vento S, Garofano T, Renzini C et al (1998) Fulminant hepatitis associated with hepatitis A Virus superinfection in patients with chronic hepatitis C. N Engl J Med 338:286–290
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Pischke, S., Wedemeyer, H. (2016). Hepatitis A. In: Manns, M., Schneidewind, S. (eds) Praxis der Hepatologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-41620-0_7
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DOI: https://doi.org/10.1007/978-3-642-41620-0_7
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