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Subtelomere Plasticity in the Bacterium Streptomyces

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Subtelomeres

Abstract

Most bacterial genomes described so far display a unique circular chromosome. However, a few exceptions to this generality exist: some bacteria carry more than one chromosome, some others carry linear chromosomes. Together with the linearity come telomeres and subtelomeres. In Streptomyces, the only bacterial genus in which linearity is the general rule, the unique chromosome has an invertron structure and shows a particularly high plasticity in the subtelomere region. This remarkable plasticity is probably the resultant of various mechanisms including: horizontal gene transfer, terminal sequence exchange between replicons (chromosomes and plasmids), illegitimate recombination. Analysis of the genetic instability under laboratory conditions as well as comparative genomics argue in favor of the high frequency of these recombination events and their preferred occurrence/selection in the subtelomere region.

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Acknowledgments

The UMR UL-INRA 1128 is supported by a grant overseen by the French National Research Agency (ANR) as part of the “Investissements d'Avenir” program (ANR-11-LABX-0002-01, Lab of Excellence ARBRE).

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  1. DynAMic UMR UL-INRA 1128, IFR 110 EFABA, Université de Lorraine, Faculté des Sciences et Technologies, BP 70239, Vandœuvre-lès-Nancy, 54506, France

    Annabelle Thibessard & Pierre Leblond

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  1. Annabelle Thibessard
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  2. Pierre Leblond
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Correspondence to Annabelle Thibessard .

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  1. Department of Genetics, University of Leicester, Leicester, United Kingdom

    Edward J Louis

  2. Department of Genetics, University of Leicester, Leicester, United Kingdom

    Marion M Becker

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Thibessard, A., Leblond, P. (2014). Subtelomere Plasticity in the Bacterium Streptomyces . In: Louis, E., Becker, M. (eds) Subtelomeres. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-41566-1_14

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