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Advanced MRI of Cartilage and Subchondral Bone in Osteoarthritis

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Advanced Computational Approaches to Biomedical Engineering

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Abstract

Osteoarthritis is a degenerative joint disorder that predominantly affects cartilage and subchondral bone. Magnetic resonance imaging (MRI) provides a noninvasive means to detect pathologic alterations in these two tissues. In this chapter, we provide an overview of MRI techniques to evaluate cartilage and subchondral bone macrostructure, and cartilage biochemical composition [T1rho mapping, T2 mapping, 23Na MRI, glycosaminoglycan chemical exchange saturation transfer, diffusion tensor imaging (DTI)]. The ability to detect early and short-term changes in the knee joint in vivo will allow new insight into the pathogenesis of osteoarthritis and may permit early diagnosis of osteoarthritis in at-risk subjects. This knowledge and capability should ultimately accelerate the discovery and testing of novel therapies to treat osteoarthritis, a disease which represents an enormous socioeconomic and health burden on society.

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Acknowledgments

This work was supported by research grants K23-AR059748, RO1-AR053133, R01-AR056260, and R01-AR060238 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH).

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Authors and Affiliations

  1. Quantitative Multinuclear Musculoskeletal Imaging Group (QMMIG), Center for Biomedical Imaging, Department of Radiology, New York University Langone Medical Center, 660 1st Avenue, 4th Floor, New York, NY, 10016, USA

    Gregory Chang & Ravinder R. Regatte

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  1. Gregory Chang
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  2. Ravinder R. Regatte
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Correspondence to Gregory Chang .

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Editors and Affiliations

  1. Dept. of Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa, USA

    Punam K. Saha

  2. Dept. of Computer Science and Engineering, Jadavpur University, Kolkata, West Bengal, India

    Ujjwal Maulik

  3. Dept. of Computer Science and Engineering, Jadavpur University, Kolkata, India

    Subhadip Basu

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Chang, G., Regatte, R.R. (2014). Advanced MRI of Cartilage and Subchondral Bone in Osteoarthritis. In: Saha, P., Maulik, U., Basu, S. (eds) Advanced Computational Approaches to Biomedical Engineering. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-41539-5_8

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  • DOI: https://doi.org/10.1007/978-3-642-41539-5_8

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