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Advanced Computational Approaches to Biomedical Engineering pp 159–175Cite as

Contemporary Problems in Quantitative Image Analysis in Structural Neuronal Plasticity

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Abstract

In studies of the brain structure at the microscopic level the analysis of microscopic images is playing currently a dominant role. Insight into the processes of structural neuronal plasticity may be a key step towards understanding the bases of various neurodegenerative diseases. Almost in each experiment, there is a need for a quantitative analysis of brain tissue images. Such analysis often requires using elaborate computational tools, due to the rich structure present in the observed images. We review the most important problems encountered in the processes of analysis of fluorescent confocal microscopy images. Each of these problems suggests a dedicated computational approach.

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Acknowledgements

The authors thank Ania Wilczyñska for help in preparing Fig. 1, and Marcelina Hajnrych for analysis of images. This work was supported by the National Science Centre Dec-2011/01/D/NZ3/00163, 7873/B/P01/2011/40, and the European Regional Development Fund POIG 01.01.02-00-008/08.

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Authors and Affiliations

  1. Nencki Institute of Experimental Biology, Laboratory of Imaging Tissue Structure and Function, Polish Academy of Sciences, Pasteura 3, Warszawa, Poland

    Błażej Ruszczycki

  2. Nencki Institute of Experimental Biology, Laboratory of Cell Biophysics, Polish Academy of Sciences, Pasteura 3, Warszawa, Poland

    Monika Bijata & Jakub Włodarczyk

  3. Nencki Institute of Experimental Biology, Laboratory of Molecular and Systemic Neuromorphology, Polish Academy of Sciences, Pasteura 3, Warszawa, Poland

    Agnieszka Walczak & Grzegorz Wilczyński

Authors
  1. Błażej Ruszczycki
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  2. Monika Bijata
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  3. Agnieszka Walczak
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  4. Grzegorz Wilczyński
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  5. Jakub Włodarczyk
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Correspondence to Błażej Ruszczycki .

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Editors and Affiliations

  1. Dept. of Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa, USA

    Punam K. Saha

  2. Dept. of Computer Science and Engineering, Jadavpur University, Kolkata, West Bengal, India

    Ujjwal Maulik

  3. Dept. of Computer Science and Engineering, Jadavpur University, Kolkata, India

    Subhadip Basu

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Ruszczycki, B., Bijata, M., Walczak, A., Wilczyński, G., Włodarczyk, J. (2014). Contemporary Problems in Quantitative Image Analysis in Structural Neuronal Plasticity. In: Saha, P., Maulik, U., Basu, S. (eds) Advanced Computational Approaches to Biomedical Engineering. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-41539-5_7

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  • DOI: https://doi.org/10.1007/978-3-642-41539-5_7

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