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Synthesis of 12- to 16-Membered-Ring Lactones

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Synthesis of Saturated Oxygenated Heterocycles II

Part of the book series: Topics in Heterocyclic Chemistry ((TOPICS,volume 36))

Abstract

A wide variety of natural products exhibit a macrocyclic lactone motif with a large spectrum of biological properties ranging from perfumery, over phytotoxicity, pheromone, or insecticide activity to medicinal (antibiotic, cytotoxic, antiangiogenesis) properties. These molecules feature a wide range of cyclic structures up to 60-membered rings. For this reason, the devise of new macrolactonization methods is always of general interest. The objective of this chapter is not only to present an overview of the macrolactonization of seco-acids in the total synthesis of natural products but to present other new effective procedures for the ring closure of 12- to 16-membered ring lactones.

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  1. Institute of Organic Chemistry, Gottfried Wilhelm Leibniz University of Hannover, Schneiderberg 1b, 30167, Hannover, Germany

    Martin Cordes & Markus Kalesse

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  1. Martin Cordes
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  2. Markus Kalesse
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Correspondence to Markus Kalesse .

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  1. ESPCI, Laboratory of Organic Chemistry, Paris Cedex 05, France

    Janine Cossy

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Cordes, M., Kalesse, M. (2014). Synthesis of 12- to 16-Membered-Ring Lactones. In: Cossy, J. (eds) Synthesis of Saturated Oxygenated Heterocycles II. Topics in Heterocyclic Chemistry, vol 36. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-41470-1_3

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