Abstract
Non-visual arrestins were initially appreciated for the roles they play in the negative regulation of G protein-coupled receptors through the processes of desensitisation and endocytosis. The arrestins are also now known as protein scaffolding platforms that act downstream of multiple types of receptors, ensuring relevant transmission of information for an appropriate cellular response. They function as regulatory hubs in several important signalling pathways that are often dysregulated in human cancers. Interestingly, several recent studies have documented changes in expression and localisation of arrestins that occur during cancer progression and that correlate with clinical outcome. Here, we discuss these advances and how changes in expression/localisation may affect functional outputs of arrestins in cancer biology.
Keywords
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Acknowledgements
We apologise to the many authors who could not be cited due to space restrictions and thank Dr S. Marullo for helpful discussions. The laboratory is part of the multidisciplinary “Who am I?” LABEX. This work was supported by the Fondation ARC pour la Recherche sur le Cancer, Ligue Contre le Cancer (comité de l’Oise), Fondation pour la Recherche Biomedicale (“Equipe FRM”), CNRS and INSERM. ELF was funded by a doctoral fellowship from the Fondation ARC pour la Recherche sur le Cancer and subsequently a postdoctoral fellowship from the National Research Fund, Luxembourg, co-funded under the Marie Curie Actions of the European Commission (FP7-COFUND).
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Enslen, H., Lima-Fernandes, E., Scott, M.G.H. (2014). Arrestins as Regulatory Hubs in Cancer Signalling Pathways. In: Gurevich, V. (eds) Arrestins - Pharmacology and Therapeutic Potential. Handbook of Experimental Pharmacology, vol 219. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-41199-1_21
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