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Enzymes of Inorganic Polyphosphate Metabolism

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Biomedical Inorganic Polymers

Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 54))

Abstract

Inorganic polyphosphate (PolyP) is a linear polymer containing a few to several hundred orthophosphate residues linked by energy-rich phosphoanhydride bonds. Investigation of PolyP-metabolizing enzymes is important for medicine, because PolyPs perform numerous functions in the cells. In human organism, PolyPs are involved in the regulation of Ca2+ uptake in mitochondria, bone tissue development, and blood coagulation. The essentiality of polyphosphate kinases in the virulence of pathogenic bacteria is a basis for the discovery of new antibiotics. The properties of the major enzymes of PolyP metabolism, first of all polyphosphate kinases and exopolyphosphatases, are described in the review. The main differences between the enzymes of PolyP biosynthesis and utilization of prokaryotic and eukaryotic cells, as well as the multiple functions of some enzymes of PolyP metabolism, are considered.

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Acknowledgments

The authors were supported by the Russian Foundation for Basic Research (Grant 11-04-01009). We thank E. Makeeva for her help with preparation of the manuscript.

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Authors and Affiliations

  1. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia

    Tatyana Kulakovskaya & Igor Kulaev

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  1. Tatyana Kulakovskaya
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  2. Igor Kulaev
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Correspondence to Tatyana Kulakovskaya .

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Editors and Affiliations

  1. ERC Advanced Investigator Group, Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Mainz, Germany

    Werner E. G. Müller

  2. ERC Advanced Investigator Group, Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Mainz, Germany

    Xiaohong Wang

  3. ERC Advanced Investigator Group, Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Mainz, Germany

    Heinz C. Schröder

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Kulakovskaya, T., Kulaev, I. (2013). Enzymes of Inorganic Polyphosphate Metabolism. In: Müller, W., Wang, X., Schröder, H. (eds) Biomedical Inorganic Polymers. Progress in Molecular and Subcellular Biology, vol 54. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-41004-8_3

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