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Prosopagnosia: The Inability to Recognize Faces

  • Davide RivoltaEmail author
Chapter
Part of the Cognitive Systems Monographs book series (COSMOS, volume 20)

Abstract

Most people recognize familiar faces rapidly, accurately and effortlessly. However, this is not true for individuals with prosopagnosia, who show a deficit in recognizing familiar people by their faces.

Keywords

Face Recognition Face Processing Face Perception Holistic Processing Face Memory 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Avidan, G. (2012). Selective dissociation between core and extended regions of the face processing network in congenital prosopagnosia Paper presented at the Annual meeting of the Society for Neuroscience, New Orleans.Google Scholar
  2. Avidan, G., & Behrmann, M. (2009). Functional MRI reveals compromised neural integrity of the face processing network in congenital prosopagnosia. Current Biology, 19, 1–5.CrossRefGoogle Scholar
  3. Avidan, G., Hasson, U., Malach, R. l, and Behrmann, M. (2005). Detailed exploration of face-related processing in congenital prosopagnosia: 2. functional neuroimaging findings. Journal of Cognitive Neuroscience, 17, 1150–1167.Google Scholar
  4. Baron-Cohen, S., Wheelwright, S., Skinner, R., Martin, J., & Clubley, E. (2001). The autism-spectrum quotient (AQ): Evidence from Asperger syndrome/high-functioning autism, males and females, scientists and mathematicians. Journal of Autism and Developmental Disorders, 31, 5–17.CrossRefGoogle Scholar
  5. Barton, J. J. (2008a). Structure and function in acquired prosopagnosia: Lesson from a series of 10 patients with brain damage. Journal of Neuropsychology, 2, 197–225.CrossRefGoogle Scholar
  6. Barton, J. J. (2008b). Structure and function in acquired prosopagnosia: Lessons from a series of 10 patients with brain damage. Journal of Neuropsychology, 2, 197–225.CrossRefGoogle Scholar
  7. Barton, J. J., Cherkasova, Mariya V., Press, Daniel Z., Intriligator, James M., & O’Connor, Margaret. (2003). Developmental prosopagnosia: A study of three patients. Brain and Cognition, 51, 12–30.CrossRefGoogle Scholar
  8. Bate, S., Cook, S. J., Duchaine, B., Tree, J. J., Burns, E. J., Hodgson, T. L. Intranasal Inhalation of Oxytocin Improves Face Processing in Developmental Prosopagnosia, Cortex. (in press).Google Scholar
  9. Behrmann, M., & Avidan, G. (2005). Congenital prosopagnosia: Face-blind from birth Trends in. Cognitive Neuroscience, 9, 180–187.CrossRefGoogle Scholar
  10. Behrmann, M., Avidan, G., Marotta, J. J., & Kimchi, R. (2005). Detailed Exploration of Face-related Processing in Congenital Prosopagnosia: 1 Behavioral Findings. Journal of Cognitive Neuroscience, 17, 1130–1149.CrossRefGoogle Scholar
  11. Behrmann, M., Avidan, G., Gao, F., & Black, S. (2007). Structural imaging reveals anatomical alterations in inferotemporal cortex in congenital prosopagnosia. Cerebral Cortex, 17, 2354–2363.CrossRefGoogle Scholar
  12. Behrmann, M., Avidan, G., Thomas, C., & Humphreys, K. (2009). Congenital and acquired prosopagnosia: Flip sides of the same coin? In I. Gauthier, M. Tarr, & D. Bub (Eds.), Perceptual expertise: Bridging brain and behaviour. Oxford: Oxford University Press.Google Scholar
  13. Bentin, S., McCarthy, G., Perez, E., Puce, A., & Allison, T. (1996). Electrophysiological studies of face perception in humans. Journal of Cognitive Neuroscience, 8, 551–565.CrossRefGoogle Scholar
  14. Bentin, S., Deouell Leon, Y., and Soroker, N. (1999). Selective visual streaming in face recognition: Evidence from developmental prosopagnosia. Neuroreport, 10, 823–827.Google Scholar
  15. Bentin, S., DeGutis, Joseph M., D’Esposito, Mark, & Robertson, Lynn C. (2007). Too many trees to see the forest: Performance, event-related potential, and functional magnetic resonance imaging manifestations of integrative congenital prosopagnosia. Journal of Cognitive Neuroscience, 19, 132–146.CrossRefGoogle Scholar
  16. Benton, A. L. (1990). Facial recognition. Cortex, 26, 491–499.CrossRefGoogle Scholar
  17. Bodamer, J. (1947). Die Prosop-agnosie. Archiv fur Psychiatrie und Nervkrankheiten, 179, 6–53.CrossRefGoogle Scholar
  18. Bowles, D. C., McKone, E., Dawel, A., Duchaine, B., Palermo, R., Schmalzl, L., Rivolta, D., Wilson, E. C., and Yovel, G. (2009). Diagnosing prosopagnosia: Effects of aging, sex, and participant-stimulus ethnic match on the Cambridge face memory test and Cambridge face perception test Cognitive Neuropsychology, 26, 423–455.Google Scholar
  19. Braun, C. M., Denault, C., Cohen, H., & Rouleau, I. (1994). Discrimination of facial identity and facial affect in temporal and frontal lobectomy patients. Brain and Cognition, 24, 198–212.CrossRefGoogle Scholar
  20. Brunsdon, R., Coltheart, M., Nickels, L., & Joy, P. (2006). Developmental prosopagnosia: A case analysis and treatment study. Cognitive Neuropsychology, 23, 822–840.CrossRefGoogle Scholar
  21. Busigny, T., Joubert, S., Felician, O., Ceccaldi, M., & Rossion, B. (2010). Holistic perception of the individual face is specific and necessary: Evidence from an extensive case study of acquired prosopagnosia. Neuropsycholgia, 48, 4057–4092.CrossRefGoogle Scholar
  22. Dalrymple, K. A., Corrow, S., Yonas, A., and Duchaine, B. (2013). Developmental prosopagnosia in childhood. Cognitive Neuropsychology, iFirst, 1–26.Google Scholar
  23. Damasio, A. R., Tranel, D., & Damasio, H. (1990). Face agnosia and the neural substrates of memory. Annual Reviews Neuroscience, 13, 89–109.CrossRefGoogle Scholar
  24. De Haan, E. H. F., & Campbell, R. A. (1991). Fifteen year follow-up of a case of developmental prosopagnosia. Cortex, 27(4): 489–509.Google Scholar
  25. De Haan, E. (1999). A familial factor in the development of face recognition deficits. Journal of Clinical and Experimental Neuropsychology, 21, 312–315.CrossRefGoogle Scholar
  26. De Haan, E. (2001). Face perception and recognition. In B. Rapp (Ed.), The handbook of cognitive neuropsychology—What deficits reveal about the human mind. Philadelphia: Psychology Press.Google Scholar
  27. Della, S. S., and Young, A. W. (2003). Quaglino’s 1867 case of prosopagnosia. Cortex, 39, 533–540.Google Scholar
  28. Denes, G., & Pizzamiglio, L. (1996). Manuale di neuropsicologia. Normalita’ e patologia dei processi cognitivi (2nd ed.). Bologna: Zanichelli.Google Scholar
  29. Dennett, H. W., McKone, E., Tavashmi, R., Hall, A., Pidcock, M., Edwards, M., and Duchaine, B. (2011). The Cambridge car memory test: A task matched in format to the Cambridge face memory test, with norms, reliability, sex differences, dissociations from face memory, and expertise effects. Behavior Research Methods.Google Scholar
  30. Diaz, A. L. (2008). Do i know you? A case study of prosopagnosia. The Journal of School Nursing, 24, 284–289.CrossRefGoogle Scholar
  31. Duchaine, B. (2011). Developmental prosopagnosia: Cognitive, neural and developmental investigations. In A. J. Calder, G. Rhodes, M. Johnson, & J. V. Haxby (Eds.), The oxford handbook of face perception. Oxford: Oxford University Press.Google Scholar
  32. Duchaine, B., & Nakayama, K. (2005). Dissociations of face and object recognition in developmental prosopagnosia. Journal of Cognitive Neuroscience, 17, 249–261.CrossRefGoogle Scholar
  33. Duchaine, B., & Nakayama, K. (2006a). The Cambridge face memory test: Results for neurologically intact individuals and an investigation of its validity using inverted face stimuli and prosopagnosic participants. Neuropsychologia, 44, 576–585.CrossRefGoogle Scholar
  34. Duchaine, B., & Nakayama, K. (2006b). Developmental prosopagnosia: A window to content-specific face processing. Current Opinion in Neurobiology, 16, 166–173.CrossRefGoogle Scholar
  35. Duchaine, B., Parker, H., and Nakayama, K. (2003). Normal recognition of emotion in a prosopagnosic. Perception, 32, 827–838.Google Scholar
  36. Duchaine, B., Yovel, G., Butterworth, E. J., and Nakayama, K. (2006). Prosopagnosia as an impairment to face-specific mechanisms: Elimination of the alternative hypotheses in a developmental case. Cognitive Neuropsychology, 23, 714–747.Google Scholar
  37. Duchaine, B., Germine, L., & Nakayama, K. (2007). Family resemblance: Ten family members with prosopagnosia and within-class object agnosia. Cognitive Neuropsychology, 24, 419–430.CrossRefGoogle Scholar
  38. Evans, J. J., Heggs, A. J., Antoun, N., & Hodges, J. R. (1995). Progressive prosopagnosia associated with selective right temporal lobe atrophy: A new syndrome? Brain, 118, 1–13.CrossRefGoogle Scholar
  39. Ewbank, M. P., Henson, R. N., Rowe, J. B., Stoyanova, R. S., & Calder, A. J. (2012). Different neural mechanisms within occipitotemporal cortex underlie repetition suppression across same and different-size faces. Cerebral Cortex. doi: 10.1093/cercor/bhs1070.Google Scholar
  40. Farah, M. J. (1996). Is face recognition ‘special’? Evidence from neuropsychology. Behavioural Brain Research, 76, 181–189.CrossRefGoogle Scholar
  41. Farah, M. J., Tanaka, J. W., & Drain, H. M. (1995). What causes the face inversion effect? Journal of Experimental Psychology: Human Perception and Performance, 21, 628–634.CrossRefGoogle Scholar
  42. Farah, M. J., Rabinowitz, C., Quinn, G. E., & Liu, G. (2000). Early commitment of neural substrates for face recognition. Cognitive Neuropsychology, 17, 117–123.CrossRefGoogle Scholar
  43. Fine, D. R. (2013). A life with prosopagnosia. Cognitive Neuropsychology, iFirst, 1–6.Google Scholar
  44. Gainotti, G. (2007). Face familiarity feelings, the right temporal lobe and the possible underlying neural mechanisms. Brain Research Reviews, 56, 214–235.CrossRefGoogle Scholar
  45. Gainotti, G., & Marra, C. (2011). Differential contribution of right and left temporo-occipital and anterior temporal lesions to face recognition disorders. Frontiers in Human Neuroscience, 5, 1–11.CrossRefGoogle Scholar
  46. Garrido, L., Furl, N., Draganski, B., Weiskopf, N., Stevens, J., Chern-Yee, T. G., Driver, J., Dolan, R. J., and Duchaine, B. C. (2009). Voxel-based morphometry reveals reduced grey matter volume in the temporal cortex of developmental prosopagnosics. Brain, 132, 3443–3455.Google Scholar
  47. Grueter, M., Grueter, T., Bell, V., Horst, J., Laskowski, W., Sperling, K., et al. (2007). Hereditary prosopagnosia: The first case series. Cortex, 43, 734–749.CrossRefGoogle Scholar
  48. Guastella, A. J., Mitchell, P. B., & Dadds, M. R. (2008). Oxytocin increases gaze to the eye region of human faces. Biological Psychiatry, 63, 3–5.CrossRefGoogle Scholar
  49. Hadjikhani, N., & De Gelder, B. (2002). Neural basis of prosopagnosia: An fMRI study. Human Brain Mapping, 16, 176–182.CrossRefGoogle Scholar
  50. Harris, A., Duchaine, B. C., and Nakayama, K. (2005). Normal and abnormal face selectivity of the M170 response in developmental prosopagnosics. Neuropsychologia, 43, 2125–2136.Google Scholar
  51. Herzmann, G., Young, B., Bird, C. W., and Curran, T. (2013). Oxytocin can impair memory for social and non-social visual objects: A within-subject investigation of oxytocin’s effects on human memory. Brain Research. Cognitive Brain Research.Google Scholar
  52. Humphreys, K., Avidan, G., & Behrmann, M. (2007). A detailed investigation of facial expression processing in congenital prosopagnosia as compared to acquired prosopagnosia. Experimental Brain Research, 176, 356–373.CrossRefGoogle Scholar
  53. Jones, R. D., & Tranel, D. (2001). Severe developmental prosopagnosia in a child with superior intellect. Journal of Clinical and Experimental Neuropsychology, 23(3):265–273.Google Scholar
  54. Kanwisher, N. (2010). Functional specificity in the human brain: A window into the functional architecture of the mind. Proceedings of the National Academy of Science USA, 107, 11163–11170.CrossRefGoogle Scholar
  55. Kanwisher, N., & Yovel, G. (2006). The fusiform face area: A cortical region specialized for the perception of faces. Philosophical Transactions of the Royal Society B, 361, 2109–2128.CrossRefGoogle Scholar
  56. Kempler, D. (2005). Neurocognitive Disorders in Aging (1st ed.). Thousand Oaks, California, US: Sage Publications, Inc.Google Scholar
  57. Kennerknecht, I., Grueter, T., Welling, B., Wentzek, S., Horst, J., Edwards, S., et al. (2006). First Report of Prevalence of Non-Syndromic Hereditary Prosopagnosia (HPA). American Journal of Medical Genetics Part A, 140A, 1617–1622.CrossRefGoogle Scholar
  58. Kress, T., & Daum, I. (2003). Developmental prosopagnosia: A review. Behavioural Neurology, 14, 109–121.Google Scholar
  59. Lang, N., Baudewig, J., Kallenberg, K., Antal, A., Happe, S., Dechent, P., et al. (2006). Transient prosopagnosia after ischemic stroke. Neurology, 66, 916.CrossRefGoogle Scholar
  60. Le Grand, R., Cooper, P. A., Mondloch, C. J., Lewis, T. L., Sagiv, N., de Gelder, B., and Maurer, D. (2006). What aspects of face processing are impaired in developmental prosopagnosia? Brain and Cognition, 61, 139–158.Google Scholar
  61. Lee, Y., Duchaine, B. C., Wilson, H. R., and Nakayama, K. (2010). Three cases of developmental prosopagnosia from one family: Detailed neuropsychological and psychophysical investigation of face processing. Cortex, 46, 949–964.Google Scholar
  62. Malach, R., Reppas, J. B., Benson, R. R., Kwong, K. K., Jiang, H., Kennedy, W., et al. (1995). Object-related activity revealed by functional magnetic resonance imaging in human occipital cortex. Proceedings of the National Academy of Sciences (PNAS) US, 92, 8135–8139.CrossRefGoogle Scholar
  63. Mattson, A. J., Levin, H. S., & Grafman, J. (2000). A case of prosopagnosia following moderate closed head injury with left hemisphere focal lesion. Cortex, 36, 125–137.CrossRefGoogle Scholar
  64. McConachie, H. R. (1976). Developmental prosopagnosia: A single case report. Cortex, 12, 76–82.CrossRefGoogle Scholar
  65. McKone, E., Hall, A., Pidcock, M., Palermo, R., Wilkinson, R. B., Rivolta, D., et al. (2011). Face ethnicity and measurement reliability affect face recognition performance in developmental prosopagnosia: Evidence from the Cambridge Face Memory Test–Australian. Cognitive Neuropsychology, 28, 109–146.CrossRefGoogle Scholar
  66. Meadows, J. C. (1974). The anatomical basis of prosopagnosia. Journal of Neurology, Neurosurgery and Psychiatry, 37, 489–501.CrossRefGoogle Scholar
  67. Minnebusch, D. A., Suchan, B., Ramon, M., & Daum, I. (2007). Event-related potentials reflect heterogeneity of developmental prosopagnosia. European Journal of Neuroscience, 25, 2234–2247.CrossRefGoogle Scholar
  68. Moscovitch, M., Winocur, G., & Behrmann, M. (1997). What is special about face recognition? Nineteen experiments on a person with visual objects agnosia and dyslexia but normal face recognition. Journal of Cognitive Neuroscience, 9, 555–604.CrossRefGoogle Scholar
  69. Palermo, R., Rivolta, D., Wilson, C. E., & Jeffery, L. (2011a). Adaptive face space cpding in congenital prosopagnosia: Typical figural aftereffects but abnormal identity aftereffects. Neuropsychologia, 49, 3801–3812.CrossRefGoogle Scholar
  70. Palermo, R., Willis, M. L., Rivolta, D., McKone, E., Wilson, C. E., & Calder, A. J. (2011b). Impaired holistic coding of facial expression and facial identity in congenital prosopagnosia. Neuropsychologia, 49, 1226–1235.CrossRefGoogle Scholar
  71. Quaglino, A., Borelli, G. B., Della Sala, S., & Young, A. W., (2003). Quaglino’s 1867 case of prosopagnosia. Cortex, 39(3):533–540.Google Scholar
  72. Ramus, F. (2004). Neurobiology of dyslexia: A reinterpretation of the data. Trends in Neuroscience, 27, 720–726.CrossRefGoogle Scholar
  73. Riddoch, M. J., Johnston, R. A., Bracewell, B. M., Boutsen, L., & Humphreys, G. W. (2008). Are faces special? A case of pure prosopagnosia. Cognitive Neuropsychology, 25, 3–26.CrossRefGoogle Scholar
  74. Righart, R., & de Gelder, B. (2007). Impaired face and body perception in developmental prosopagnosia. Proceedings of the National Academy of Science USA, 104, 17234–17238.CrossRefGoogle Scholar
  75. Rivolta, D. (2010). Face processing in typical and congenitally prosopagnosic adults: Behavioural and neuroimaging investigations. PhD: Macquarie University, Sydney.Google Scholar
  76. Rivolta, D., Schmalzl, L., Coltheart, M., & Palermo, R. (2010). Semantic information can facilitate covert face recognition in congenital prosopagnosia. Journal of Clinical and Experimental Neuropsychology, 32, 1002–1016.CrossRefGoogle Scholar
  77. Rivolta, D., Schmalzl, L., Palermo, R., and Williams, M. A. (2011). Multi-voxel pattern analysis of fMRI data reveals abnormal anterior temporal lobe activity in congenital prosopagnosia. Paper presented at the European Conference on Visual Perception (ECVP) Toulouse.Google Scholar
  78. Rivolta, D., Palermo, R., Schmalzl, L., & Williams, M. A. (2012). Investigating the features of the M170 in congenital prosopagnosia. Frontiers in Human Neuroscience, 6, 45.CrossRefGoogle Scholar
  79. Rossion, B. (2009). Clarifying the functional neuroanatomy of face perception by single case neuroimaging studies of acquired prosopagnosia. In Michael Jenkin & Laurence Harris (Eds.), Cortical Mechanisms of Vision (pp. 171–207). Cambridge: Cambridge University Press.Google Scholar
  80. Rossion, B., Caldara, R., Seghier, M., Schuller, A.-M., Lazeyras, F., & Mayer, E. (2003). A network of occipito-temporal face-sensitive areas besides the right middle fusiform gyrus is necessary for normal face processing. Brain, 126, 2381–2395.CrossRefGoogle Scholar
  81. Savaskan, E., Ehrhardt, R., Schultz, A., Walter, M., & Schächinger, H. (2008). Post-learning intranasal oxytocin modulates human memory for facial identity. Psychoneuroendocrinology, 33, 368–374.CrossRefGoogle Scholar
  82. Schmalzl, L. (2007). Fractionating face processing in congenital prosopagnosia. Ph.D., Macquarie University, Sydney, Australia. (BF242,S48).Google Scholar
  83. Schmalzl, L., Palermo, R., & Coltheart, M. (2008a). Cognitive heterogeneity in genetically based prosopagnosia: A family study. Journal of Neuropsychology, 2, 99–117.CrossRefGoogle Scholar
  84. Schmalzl, L., Palermo, R., Green, M., Brunsdon, R., & Coltheart, M. (2008b). Training of familiar face recognition and visual scan paths for faces in a child with congenital prosopagnosia. Cognitive Neuropsychology, 25, 704–729.CrossRefGoogle Scholar
  85. Schultz, R. T. (2005). Developmental deficits in social perception in autism: The role of the amygdala and fusiform face area. International Journal of Developmental Neuroscience, 23, 125–141.CrossRefGoogle Scholar
  86. Sergent, J., & Signoret, J. L. (1992). Varieties of functional deficits in prosopagnosia. Cerebral Cortex, 2, 375–388.CrossRefGoogle Scholar
  87. Sparr, S. A., Jay, M., Drislane, F. W., & Venna, N. (1991). A historic case of visual agnosia revisited after 40 years. Brain, 114, 789–800.CrossRefGoogle Scholar
  88. Steeves, J. K. E., Culham, J. C., Duchaine, B., Cavina Pratesi, C., Valyear, K., Schindler, I., Humphrey, K., Milner, A. D., and Goodale, M. A. (2006). The fusiform face area is not sufficient for face recognition: Evidence from a patient with dense prosopagnosia and no occipital face area. Neuropsycholgia, 44, 596–609.Google Scholar
  89. Steeves, J. K. E., Dricot, L., Golzz, H. C., Sorger, B., Peters, J., Milner, A. D., et al. (2009). Abnormal face identity coding in the middle fusiform gyrus of two brain-damaged prosopagnosics patients. Neuropsycholgia, 47, 2584–2592.CrossRefGoogle Scholar
  90. Sugimoto, A., Miller, M. W., Kawai, Y., Shiota, J., & Kawamura, M. (2011). Another piece of the jigsaw: A case report of prosopagnosia with symptomatological, imaging and post mortem anatomical evidence. Cortex. doi: 10.1016/j.cortex.2011.1004.1003.Google Scholar
  91. Susilo, T., McKone, E., Dennett, H., Darke, H., Palermo, R., Hall, A., et al. (2011). Face recognition impairments despite normal holistic processing and face space coding: Evidence from a case of developmental prosopagnosia. Cognitive Neuropsychology, 27, 636–664.CrossRefGoogle Scholar
  92. Thomas, C., Avidan, G., Humphreys, K., Gao, F., and Behrmann, M. (2009). Reduced structural connectivity in ventral visual cortex in congenital prosopagnosia. Nature Neuroscience, 12, 29–31.Google Scholar
  93. Towler, J., Gosling, A., Duchaine, B., and Eimer, M. (2012). The face-sensitive N170 component in developmental prosopagnosia. Neuropsycholgia, http://dx.doi.org/10.1016/j.neuropsychologia.2012.10.017.
  94. Wada, Y., & Yamamoto, T. (2001). Selective impairment of facial recognition due to haematoma restricted to the right fusiform and lateral occipital area. Journal of Neurology, Neurosurgery and Psychiatry, 71, 254–257.CrossRefGoogle Scholar
  95. Warrington, E. K. (1984). Recognition memory test, Windsor (UK): NFER- NELSON.Google Scholar
  96. Williams, Mark, Savage, Greg, & Halmagyi, Michael. (2006). Abnormal configural face perception in a patient with right anterior temporal lobe atrophy. Neurocase, 12, 286–291.CrossRefGoogle Scholar
  97. Williams, M. A., Berberovic, N., & Mattingley, J. B., (2007). Abnormal FMRI adaptation to unfamiliar faces in a case of developmental prosopamnesia. Current Biology, 17(14):1259–1264. Google Scholar
  98. Wilson, C. E., Freeman, P., Brock, J., Burton, A. M., & Palermo, R. (2010a). Facial identity recognition in the broader autism phenotype. PLoS ONE, 5, e12876. doi: 10.1371/journal.pone.0012876.CrossRefGoogle Scholar
  99. Wilson, C. E., Palermo, R., Schmalzl, L., and Brock, J. (2010b). Specificity of impaired facial identity recognition in children with suspected developmental prosopagnosia. Cognitive Neuropsychology, 27, 30–45.Google Scholar
  100. Yardley, L., McDermott, L., Pisarski, S., Duchaine, B., & Nakayama, K. (2008). Psychosocial consequences of developmental prosopagnosia: A problem of recognition. Journal of Psychosomatic Research, 65, 445–451.CrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of NeurophysiologyMax-Planck Institute for Brain ResearchFrankfurt am MainGermany

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