Zusammenfassung
Der infarktbedingte kardiogene Schock – meist die Folge eines linksventrikulären Pumpversagens – hat mit einer Sterblichkeit von 50-80% weiterhin eine schlechte Prognose. Therapieentscheidend ist die möglichst frühzeitige Wiedereröffnung des verschlossenen Koronargefäßes. Die Schockbehandlung beinhaltet die medikamentöse Herz-Kreislauf-Therapie mit Dobutamin als Inotropikum und Noradrenalin als Vasopressor der Wahl, gesteuert anhand einer Kombination von Druck- und Flussparametern, z. B. einem mittleren Blutdruck von 65-75 mmHg und einem Herzindex >2,51/min/m2. Die bestmögliche Therapie des kardiogenen Schocks beinhaltet zudem die intensivrnedizinischen Maßnahmen zur Vermeidung bzw. Behandlung des Multiorgandysfunktionssyndroms.
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Literature
Webb JG, Sleeper LA, Buller CE et al (2000) Implications of the timing of onset of cardiogenic shock after acute myocardial infarction: a reportfrom the SHOCKTrial Registry. SHould we emergently revascu- larize Ocduded Coronaries for car¬diogenic shocK? J Am Coli Cardiol 36:1084–1090
HochmanJS, Buller CE, Sleeper LA et al (2000) Cardiogenic shock com- plicating acute myocardial infarctionetiologies, managementand outcome: a report from the SHOCK Trial Registry. SHould we emergently revascularize ocduded coro¬naries for cardiogenic shocK? J Am Coli Cardiol 36:1063–1070
Goldberg RJ, Spencer FA, Gore JM et al (2009) Thirty-year trends (1975-2005) in the magnitude of, management of, and hospital de- ath rates associated with cardiogenic shock in patients with acu-te myocardial infarction. Circulation 119:112–119
Werdan K, Ruß M, Buerke M et al (2011) Cardiogenic shock due to myocardial infarction: diagnosis, monitoring and treatment. A Ger- man-Austrian S3 guideline. Dtsch Arztebl Int 109:343-351. (Kardiologe (2011) 5:166-224; Intensivmed (2011) 48:291 -344; Intensiv- und Notfallbehandlung (2012) 2:249–130)
Menon V, Slater JN, White HD et al (2000) Acute myocardial infarcti¬on complicated by systemic hypo- perfusion without hypotension: report of the SHOCK trial registry. Am J Med 108:374–380
HochmanJS, Sleeper LA, Webb JG etal (1999) Early revascularizati- on in acute myocardial infarction complicated by cardiogenic shock. SHOCK Investigators. Should we emergently revascularize occluded coronaries for cardiogenic shock. N Engl J Med 341:625–634
HochmanJS, Sleeper LA, White HD et al (2001) One-year survival follo- wing early revascularization for cardiogenic shock. JAMA 285:190–192
HochmanJS, Sleeper LA, Webb JG et al (2006) Early revascularization and long-term survival in cardiogenic shock complicating acute myocardial infarction JAMA 295:2511¬2515
S3-Leitlinie Infarktbedingter kar- diogener Schock - Diagnose, Mo¬nitoring und Therapie. http://leitli- nien.net/ AWMF-Leitlinien-Regis- ter Nr. 019/013; Entwicklungsstu¬fe 3+IDA; HTML-Code aktualisiert: 25. Juni 2011
White HD, Assmann SF, Sanborn TA et al (2005) Comparison of per- cutaneous coronary Intervention and coronary artery bypass graf- ting after acute myocardial infarction complicated by cardiogenic shock: results from the Should We Emergently Revascularize Oc¬cluded Coronaries for Cardioge¬nic Shock (SHOCK) trial. Circulation 112:1992–2001
Picard MH, Davidoff R, Sleeper LA et al (2003) Echocardiographic pre- dictorsof survival and response to early revascularization in cardiogenic shock. Circulation 107:279–284
Russ MA, Prondzinsky R, Christoph A et al (2007) Hemodynamic im- provementfollowing levosimen- dan treatment in patients with acute myocardial infarction and cardiogenic shock. Crit Care Med 35:2732–2739
Alexander JH, Reynolds HR, Steb- bins AL et al (2007) Effect of tilargi- nine acetate in patients with acute myocardial infarction and cardiogenic shock: theTRIUMPH ran- domized controlled trial. JAMA 297:1657–1666
SakrY, Reinhart K, Vincent JL et al (2006) Does dopamine administra¬tion in shock influence outcome? Results of the Sepsis Occurrence in Acutely III Patients (SOAP) Study. Crit Care Med 34:589–597
De Backer D, Biston P, Devriendt J etal (2010) Comparison of dopa¬mine and norepinephrine in the treatment of shock. N Engl J Med 362:779–789
Fuhrmann JT, Schmeisser A, Schulze MR et al (2008) Levosimendan is superiorto enoximone in refracto- ry cardiogenic shock complicating acute myocardial infarction. Crit Care Med 36:2257–2266
Prondzinsky R, Lemm H, Swy- ter M et al (2010) Intra-aortic bal- loon counterpulsation in patients with acute myocardial infarction complicated by cardiogenic shock: the prospective, randomized IABP SHOCKTrial for attenuation of mul¬tiorgan dysfunction Syndrome. Crit Care Med 38:152–160
Unverzagt S, Machemer MT, Solms A et al (2011) Intra-aortic balloon pump counterpulsation (IABP) for myocardial infarction complicated by cardiogenic shock. Cochrane Database Syst Rev:CD007398
Sjauw KD, Engstrom AE, Vis MM et al (2009) A systematic review and meta-analysis of intra-aortic balloon pump therapy in ST-eleva- tion myocardial infarction: should we change the guidelines? Eur He- artJ
Thiele H, Smalling RW, Schuler GC (2007) Percutaneous left ventricu- lar assist devices in acute myocardial infarction complicated by cardiogenic shock. Eur Heart J 28:2057–2063
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Ruß, M., Buerke, M., Werdan, K. (2013). Therapie des infarktbedingten kardiogenen Schocks. In: Dirks, B., Somasundaram, R., Waydhas, C., Zeymer, U. (eds) Weiterbildung Notfallmedizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-40720-8_5
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