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SV40 and the Lung

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Viruses and the Lung

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Abstract

Subsequent to its identification as an inadvertent contaminant of early poliovirus vaccines and in view of its potential to induce a number of tumors in animal models, simian virus 40 (SV40) has become among the most studied animal viruses. Studies of SV40’s molecular biology have led to important discoveries in viral-induced carcinogenesis, but the actual role for SV40 in the causation of human disease remains a complex and highly debated topic. The inadvertent exposure to SV40 through contaminated vaccine lots, affecting millions of people in the United States alone, has sparked one of the most elaborate, contentious, and controversial debates in contemporary oncologic research. It is the purpose of this chapter to review the capacity of the virus to infect humans and to cause disease, particularly in the lung and its serosal membrane, the pleura.

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References

  • Bikel I, Montagno X, Agha ME et al (1987) SV40 small t antigen enhances the transformation activity of limiting concentrations of SV40 large T antigen. Cell 48:321–330

    Article  CAS  PubMed  Google Scholar 

  • Bochetta M, Di Resta I, Powers A et al (2000) Human mesothelial cells are unusually susceptible to simian virus 40-mediated transformation and asbestos cocarcinogenicity. Proc Natl Acad Sci 97:10214–10219

    Article  Google Scholar 

  • Brousset P, Sabatier J, Galateau-Salle F (2005) SV40 infection in human cancers. Ann Oncol 16:1212–1213

    Article  CAS  PubMed  Google Scholar 

  • Butel JS, Lednicky JA (1999) Cell and molecular biology of simian virus 40: implications for human infections and disease. J Natl Cancer Inst 91:119–134

    Article  CAS  PubMed  Google Scholar 

  • Carbone M, Pass HI, Rizzo P et al (1994) Simian virus 40-like DNA sequences in human pleural mesothelioma. Oncogene 9:1781–1790

    CAS  PubMed  Google Scholar 

  • Carbone M, Rizzo P, Grimley PM et al (1997) Simian virus 40 large-T antigen binds p53 in human mesotheliomas. Nat Med 3:908–912

    Article  CAS  PubMed  Google Scholar 

  • Carter JJ, Madeleine MM, Wipf GC et al (2003) Lack of serologic evidence for prevalent simian virus 40 infection in humans. J Natl Cancer Inst 95:1522–1530

    Article  PubMed  Google Scholar 

  • Cicala C, Pompetti F, Carbone M (1993) SV40 induces mesotheliomas in hamsters. Am J Pathol 142:1524–1533

    CAS  PubMed  Google Scholar 

  • Cutrone R, Lednicky J, Dunn G et al (2005) Some oral poliovirus were contaminated with infectious SV40 after 1961. Cancer Res 65:10273–10279

    Article  CAS  PubMed  Google Scholar 

  • Dhaene K, Verhulst A, Van Marck E (1999) SV40 large T antigen and human mesothelioma: screening by polymerase chain reaction and tyramine-amplified immunohistochemistry. Virchows Arch 435:1–7

    Article  CAS  PubMed  Google Scholar 

  • Egli A, Infanti L, Dumoulin A et al (2009) Prevalence of polyomavirus BK and JC infection and replication in 400 healthy blood donors. J Infect Dis 199:837–846

    Article  CAS  PubMed  Google Scholar 

  • Engels EA, Katki HA, Nielsen NM et al (2003) Cancer incidence in Denmark following exposure to poliovirus contaminated with simian virus 40. J Natl Cancer Inst 95:532–539

    Article  CAS  PubMed  Google Scholar 

  • Feng H, Shuda M, Chang Y et al (2008) Clonal integration of polyomavirus in human Merkel cell carcinoma. Science 319:1096–1100

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Foddis R, De Rienzo A, Broccoli D et al (2002) SV40 infection induces telomerase activity in human mesothelial cells. Oncogene 21:1434–1442

    Article  CAS  PubMed  Google Scholar 

  • Galateau-Salle F, Bidet PH, Iwatsubo Y et al (1998) SV40-like DNA sequences in pleural mesothelioma, bronchopulmonary carcinoma and non-malignant pulmonary diseases. J Pathol 184:252–257

    Article  CAS  PubMed  Google Scholar 

  • Garcea RL, Imperiale M (2003) Simian virus 40 infection of humans. J Virol 77:5039–5045

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Gazdar AF, Butel JS, Carbone M (2002) SV40 and human tumors: myth, association or causality? Nat Rev Cancer 2:957–964

    Article  CAS  PubMed  Google Scholar 

  • Gerber P, Hottle GA, Grubbs RE (1961) Inactivation of vacuolating virus (SV40) by formaldehyde. Proc Soc Exp Biol Med 108:205–209

    Article  CAS  PubMed  Google Scholar 

  • Hahn WC, Counter CM, Lundberg AS et al (1999) Creation of human tumor cells with defined genetic elements. Nature 400:464–468

    Article  CAS  PubMed  Google Scholar 

  • Hahn WC, Dessain SK, Brooks MW et al (2002) Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Mol Cell Biol 22:2111–2123

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Jasani B, Cristaudo A, Emri SA et al (2001) Association of SV40 with human tumors. Semin Cancer Biol 11:49–61

    Article  CAS  PubMed  Google Scholar 

  • Johne R, Buck CB, Allander T et al (2011) Taxonomical developments in the family Polyomaviridae. Arch Virol 156:1627–1634

    Article  CAS  PubMed  Google Scholar 

  • Lazarus HM, Sporn MB, Smith JM et al (1967) Purification of T antigen from nuclei of simian virus 40-induced hamster tumors. J Virol 1:1093–1095

    CAS  PubMed Central  PubMed  Google Scholar 

  • Lopez-Rios F, Illei PB, Rusch V et al (2004) Evidence against a role for SV40 infection in human mesotheliomas and high risk of false-positive PCR results owing to presence of SV40 sequences in common laboratory plasmids. Lancet 364:1157–1166

    Article  CAS  PubMed  Google Scholar 

  • Manfredi JJ, Dong J, Liu WJ et al (2005) Evidence against a role for SV40 in human mesothelioma. Cancer Res 65:2602–2609

    Article  CAS  PubMed  Google Scholar 

  • Poulin DL, DeCaprio JA (2006) Is there a role for SV40 in human cancer? J Clin Oncol 234:4356–4365

    Article  Google Scholar 

  • Rollison DEM, Page WF, Crawford H et al (2004) Case–control study of cancer among US army veterans exposed to simian virus 40-contaminated adenovirus vaccine. Am J Epidemiol 160:317–324

    Article  PubMed  Google Scholar 

  • Shah K (2006) SV40 and human cancer: a review of recent data. Int J Cancer 120:2115–2223

    Google Scholar 

  • Shah K, Nathanson N (1976) Human exposure to SV40: review and comment. Am J Epidemiol 103:1–12

    CAS  PubMed  Google Scholar 

  • Shuda M, Arora R, Kwun HJ et al (2009) Human Merkel cell polyomavirus infection. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissue and lymphoid tumors. Int J Cancer 125:1243–1249

    Article  CAS  PubMed  Google Scholar 

  • Sporn T, Roggli V (2004) Mesothelioma, Chap 5. In: Roggli VL, Oury TD, Sporn TA (eds) Pathology of asbestos-associated diseases, 2nd edn. Springer, New York

    Google Scholar 

  • Stolt A, Sasnauskas K, Koskela P et al (2003) Seroepidemiology of the human polyomaviruses. J Gen Virol 84:1499–1504

    Article  CAS  PubMed  Google Scholar 

  • Stratton K, Alamario DA, McCormick MC (eds) (2003) Immunization safety review: SV40 contamination of polio vaccine and cancer, Institute of Medicine of the National Academies. The National Academies Press, Washington, DC, p 101

    Google Scholar 

  • Strickler HD (2001) SV40 and human cancers. Einstein Quart J Biol Med 18:14–20

    Google Scholar 

  • Strickler HD, Goedert JJ, Bueno R et al (2001) The International SV40 Working Group. A multicenter evaluation of assays for detection of SV40 DNA and results in masked mesothelioma specimens. Cancer Epidemiol Biomarkers Prev 10:523–532

    CAS  PubMed  Google Scholar 

  • Strickler HD, Goedert J, Devesa SS et al (2003) Trends in US pleural mesothelioma rates following SV40 contamination of early poliovirus vaccines. J Natl Cancer Inst 95:38–45

    Article  CAS  PubMed  Google Scholar 

  • Sweet BH, Hilleman MR (1960) The vacuolating virus SV40. Proc Soc Exp Biol Med 105:420–427

    Article  CAS  PubMed  Google Scholar 

  • Viscidi RP, Rollison DEM, Viscidi E et al (2003) Serologic cross reactivities between antibodies to simian virus 40, BK virus and JC virus assessed by virus-like particle-based enzyme immunoassays. Clin Diagn Lab Immunol 10:278–285

    CAS  PubMed Central  PubMed  Google Scholar 

  • Weggen S, Bayer TA, von Deimling A et al (2002) Low frequency of SV40, JC and BK polyomavirus sequences in human medulloblastomas, meningiomas and ependymomas. Brain Pathol 10:85–92

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, Duke University, DUMC 3712, Durham, NC, 27710, USA

    Thomas A. Sporn M.D.

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  1. Thomas A. Sporn M.D.
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Correspondence to Thomas A. Sporn M.D. .

Editor information

Editors and Affiliations

  1. Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA

    Armando E. Fraire

  2. Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA

    Bruce A. Woda

  3. Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA

    Raymond M. Welsh

  4. Massachusetts General Hospital, Boston, Massachusetts, USA

    Richard L. Kradin

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© 2014 Springer-Verlag Berlin Heidelberg

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Sporn, T.A. (2014). SV40 and the Lung. In: Fraire, A., Woda, B., Welsh, R., Kradin, R. (eds) Viruses and the Lung. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-40605-8_22

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  • DOI: https://doi.org/10.1007/978-3-642-40605-8_22

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-40604-1

  • Online ISBN: 978-3-642-40605-8

  • eBook Packages: MedicineMedicine (R0)

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