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Viruses and the Lung pp 171–175Cite as

Human Papillomavirus-Related Pulmonary Neoplasia

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Abstract

Infection secondary to human papillomavirus (HPV) is one of the most common sexually transmitted infections worldwide. It has been estimated that the majority of individuals who engage in sexual activity become infected at some point in their lifetime (Baseman 2005). Considerable interest, partly related to their oncogenic potential, has resulted in major changes in the understanding of these viruses in recent years (Bravo 2010). HPVs are non-enveloped; virions are icosahedral with diameters of 50–55 nm (Fig. 19.1). The capsid contains two structural proteins: L1, the most abundant viral protein, and L2. The PV genome consists of a single molecule of circularized dsDNA (Zheng 2006). The open reading frames for all viral genes are located on only one of the DNA strands, and transcription proceeds in a single direction. There are eight early (E) open reading frames that encode for regulatory proteins that control viral metabolism and DNA synthesis. The E6 proteins of high-risk HPV types have antiapoptotic effects and interfere with p53 regulatory function in infected host cells (Howley 1990). Two late (L) reading frames encode for synthesis of the structural proteins L1 and L2.

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References

  • Ang KK, Harris J, Wheeler R (2010) Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med 363:24–35

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Baba M, Castillo A, Koriyama C et al (2010) Human papillomavirus is frequently detect in gefitinib – responsive lung adenocarcinoma. Oncol Rep 23:1085–1092

    CAS  PubMed  Google Scholar 

  • Baker TS, Newcomb WW, Olson NH et al (1991) Structuring of bovine and human papillomaviruses. Analysis by cryoelectron microscopy and three dimensional image reconstruction. Biophys J 60:1445–1456

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Baseman JG, Koutsky LA (2005) The epidemiology of human papillomavirus infections. J Clin Virol 32:S16–S24

    Article  PubMed  Google Scholar 

  • Bravo IG, de Sanjosé S, Gottschling M (2010) The clinical importance of understanding the evolution of papillomaviruses. Trends Microbiol 18:432–438

    Article  CAS  PubMed  Google Scholar 

  • Chaturvedi AK, Engels EA, Pfeiffer RM et al (2011) Human papillomavirus and rising oropharyngeal cancer in the United States. J Clin Oncol 29:4294–4301

    Article  PubMed  Google Scholar 

  • Check W (2012) New guidelines could jump-start hrHPV testing. CAP Today, College of American Pathologists 26:70–76

    Google Scholar 

  • Chivukula M, Dabbs DJ (2010) Immunocytology, Chap 21. In: Dabbs DJ (ed) Diagnostic immunohistochemistry. Theranostic and genomic applications, 3rd edn. Saunders Elsevier, Philadelphia, pp 890–918

    Google Scholar 

  • Ciotti J, Giuliani L, Ambrogi V et al (2006) Detection and expression of human papillomavirus oncogenes. Oncol Rep 16:183–189

    CAS  PubMed  Google Scholar 

  • Clavel CE, Nawrocki B, Bosseaux B et al (2000) Detection of human papillomavirus DNA in bronchopulmonary carcinomas by hybrid capture II. Cancer 88:1347–1352

    Article  CAS  PubMed  Google Scholar 

  • Coissard CJ, Besson G, Polette MC et al (2005) Prevalence of human papillomaviruses in lung carcinomas: a study of 218 cases. Mod Pathol 18:1606–1609

    PubMed  Google Scholar 

  • D’Souza G, Kreimer AR, Viscidi R et al (2007) Case control study of human papillomavirus and oropharyngeal cancer. N Engl J Med 356:1944–1956

    Article  PubMed  Google Scholar 

  • de Villiers E, Fauquet C, Broker TR et al (2004) Classification of papillomaviruses. Virology 324:17–27

    Article  PubMed  Google Scholar 

  • Doxtader EE, Katzenstein AL (2012) The relationship between p16 expression and high-risk human papillomavirus infection in squamous cell carcinomas from sites other than uterine cervix: a study of 137 cases. Hum Pathol 43:327–332

    Article  CAS  PubMed  Google Scholar 

  • Flieder DB, Koss MN, Nicholson A et al (1998) Solitary pulmonary papillomas in adults; a clinicopathologic and in situ hybridization study of 14 cases combined with 27 cases in the literature. Am J Surg Pathol 22:1328–1342

    Article  CAS  PubMed  Google Scholar 

  • Goto A, Li C-P, Ota S et al (2011) Human papillomavirus infection in lung and esophageal cancers: analysis of 485 Asian cases. J Med Virol 83:1383–1390

    Article  PubMed  Google Scholar 

  • Herrero R, Castellsagué X, Pawlita M et al (2003) Human papillomavirus and oral cancer: the international agency for research on cancer multicenter study. J Natl Cancer Inst 95:1772–1783

    Article  PubMed  Google Scholar 

  • Klein F, Walced FM, Kotb A et al (2009) Incidence of human papillomavirus in lung cancer. Lung Cancer 65:13–18

    Article  PubMed  Google Scholar 

  • Koshiol J, Rotunno M, Gillison ML et al (2011) Assessment of human papillomavirus in lung tumor tissue. J Natl Cancer Inst 103:510–507

    Article  Google Scholar 

  • Luc GT, Morris A, Sikora AG et al (2010) Second primary cancers after an index heat and neck cancer: subsite specific trends in the era of human papillomavirus – associated oropharyngeal cancer. J Clin Oncol 29:739–746

    Google Scholar 

  • Marur S, D’Souza G, Westra WH et al (2010) HPV associated head and neck cancer: a virus-related cancer epidemic. Lancet Oncol 11:781–789

    Article  PubMed  Google Scholar 

  • Srinivasan M, Taioli E, Ragin CC (2009) Human papillomavirus type 16 and 18 in primary lung cancers – a meta-analysis. Carcinogenesis 30:1722–1728

    Article  CAS  PubMed  Google Scholar 

  • Syrjänen KJ (1980) Epithelial lesions suggestive of a condylomatous origin found closely associated with invasive bronchial squamous cell carcinomas. Respiration 40:150–160

    Article  PubMed  Google Scholar 

  • Syrjänen KJ, Silvoniemi M, Salminen E et al (2012) Detection of human papillomavirus genotypes in bronchial cancer using sensitive multimetrix assay. Anticancer Res 32:625–631

    PubMed  Google Scholar 

  • Trillo A, Guha A (1988) Solitary condylomatous papilloma of the bronchus. Arch Pathol Lab Med 112:731–733

    CAS  PubMed  Google Scholar 

  • Viscidi RP, Shah KV (2009) Human papillomatosis viruses, Chap 24. In: Specter S, Hodinka RL, Young SA, Wiedbrauk DL (eds) Clinical virology manual, 4th edn. ASM Press, Washington DC, pp 408–416

    Google Scholar 

  • Werness BA, Levine AJ, Howley PM (1990) Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science 248:76–79

    Article  CAS  PubMed  Google Scholar 

  • Williams GR, Lu QL, Love SB et al (1996) Properties of HPV positive and HPV negative anal carcinomas. J Pathol 180:378–382

    Article  CAS  PubMed  Google Scholar 

  • Yu Y, Yang A, Hu S et al (2009) Correlation of HPV-16/18 infection of human papillomavirus with lung squamous cell carcinomas in western China. Oncol Rep 21:1627–1632

    CAS  PubMed  Google Scholar 

  • Zandberg DP, Bhargava R, Badin S et al (2013) The role of human papillomavirus in non genital cancers. CA Cancer J Clin 63:57–81

    Article  PubMed  Google Scholar 

  • Zhao C, Yang H (2012) Approved assays for detecting HPV DNA-design, indications and validation. CAP Today, College of American Pathologists 26:40–44

    Google Scholar 

  • Zheng ZM, Baker CC (2006) Papillomavirus genome structure, expression, and post-transcriptional regulation. Front Biosci 11:2286–2302

    Article  CAS  PubMed Central  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Pathology, UMass Memorial Medical Center, University of Massachusetts Medical School, One Innovation Drive, Worcester, MA, 01605, USA

    Armando E. Fraire M.D.

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  1. Armando E. Fraire M.D.
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Correspondence to Armando E. Fraire M.D. .

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Editors and Affiliations

  1. Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA

    Armando E. Fraire

  2. Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA

    Bruce A. Woda

  3. Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA

    Raymond M. Welsh

  4. Massachusetts General Hospital, Boston, Massachusetts, USA

    Richard L. Kradin

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© 2014 Springer-Verlag Berlin Heidelberg

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Fraire, A.E. (2014). Human Papillomavirus-Related Pulmonary Neoplasia. In: Fraire, A., Woda, B., Welsh, R., Kradin, R. (eds) Viruses and the Lung. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-40605-8_19

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  • DOI: https://doi.org/10.1007/978-3-642-40605-8_19

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-40604-1

  • Online ISBN: 978-3-642-40605-8

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