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Imaging of Hilar Cholangiocarcinoma for Liver Transplantation

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Biliary Tract and Gallbladder Cancer

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

Liver transplantation and resection for hilar cholangiocarcinoma are mutually exclusive therapeutic pathways, without possibility of cross over. Interpretation of relevant imaging is essential for accurate preoperative diagnosis, operative planning, management of complications during neoadjuvant therapy, and post-transplant surveillance of patients with hilar cholangiocarcinoma. Preoperatively, careful and dynamic interpretation of both cross-sectional imaging and cholangiography is needed to appreciate tumor presence, location, and vascular involvement. While many post-transplant vascular complications can be managed with percutaneous endovascular techniques, a number of specific vascular complications are preferentially treated operatively. An experienced multidisciplinary team is required for successful treatment of hilar cholangiocarcinoma with liver transplantation.

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References

  1. Bismuth H, Corlette MB (1975) Intrahepatic cholangioenteric anastomosis in carcinoma of the hilus of the liver. Surg Gynecol Obstet 140:170–178

    PubMed  CAS  Google Scholar 

  2. Rosen CB, Nagorney DM, Wiesner RH, Coffey RJ Jr, LaRusso NF (1991) Cholangiocarcinoma complicating primary sclerosing cholangitis. Ann Surg 213:21–25

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  3. Rosen CB, Heimbach JK, Gores GJ (2008) Surgery for cholangiocarcinoma: the role of liver transplantation. HPB (Oxford) 10:186–189

    Article  CAS  Google Scholar 

  4. Ruys AT, van Beem BE, Engelbrecht MR, Bipat S, Stoker J, van Gulik TM (2012) Radiological staging in patients with hilar cholangiocarcinoma: a systematic review and meta-analysis. Br J Radiol 85:1255–1262

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  5. Hyodo T, Kumano S, Kushihata F et al (2012) CT and MR cholangiography: advantages and pitfalls in perioperative evaluation of biliary tree. Br J Radiol 85:887–896

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  6. Khan SA, Davidson BR, Goldin RD et al (2012) Guidelines for the diagnosis and treatment of cholangiocarcinoma: an update. Gut 61:1657–1669

    Article  PubMed  CAS  Google Scholar 

  7. Maccioni F, Martinelli M, Al Ansari N et al (2010) Magnetic resonance cholangiography: past, present and future: a review. Eur Rev Med Pharmacol Sci 14:721–725

    PubMed  CAS  Google Scholar 

  8. Manfredi R, Masselli G, Maresca G, Brizi MG, Vecchioli A, Marano P (2003) MR imaging and MRCP of hilar cholangiocarcinoma. Abdom Imaging 28:319–325

    Article  PubMed  CAS  Google Scholar 

  9. Masselli G, Gualdi G (2008) Hilar cholangiocarcinoma: MRI/MRCP in staging and treatment planning. Abdom Imaging 33:444–451

    Article  PubMed  Google Scholar 

  10. Ariff B, Lloyd CR, Khan S et al (2009) Imaging of liver cancer. World J Gastroenterol 15:1289–1300

    Article  PubMed Central  PubMed  Google Scholar 

  11. Kim HJ, Kim AY, Hong SS et al (2006) Biliary ductal evaluation of hilar cholangiocarcinoma: three-dimensional direct multi-detector row CT cholangiographic findings versus surgical and pathologic results–feasibility study. Radiology 238:300–308

    Article  PubMed  Google Scholar 

  12. Endo I, Shimada H, Sugita M et al (2007) Role of three-dimensional imaging in operative planning for hilar cholangiocarcinoma. Surgery 142:666–675

    Article  PubMed  Google Scholar 

  13. Chapman WC, Sharp KW, Weaver F, Sawyers JL (1989) Tumor seeding from percutaneous biliary catheters. Ann Surg 209:708–713

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  14. Sakata J, Shirai Y, Wakai T, Nomura T, Sakata E, Hatakeyama K (2005) Catheter tract implantation metastases associated with percutaneous biliary drainage for extrahepatic cholangiocarcinoma. World J Gastroenterol 11:7024–7027

    PubMed  Google Scholar 

  15. Matsuo K, Rocha FG, Ito K et al (2012) The Blumgart preoperative staging system for hilar cholangiocarcinoma: analysis of resectability and outcomes in 380 patients. J Am Coll Surg 215:343–355

    Article  PubMed  Google Scholar 

  16. Friesen BR, Gibson RN, Speer T, Vincent JM, Stella D, Collier NA (2011) Lobar and segmental liver atrophy associated with hilar cholangiocarcinoma and the impact of hilar biliary anatomical variants: a pictorial essay. Insights Imaging 2:525–531

    Article  PubMed Central  PubMed  Google Scholar 

  17. Zaydfudim VM, Clark CJ, Kendrick ML et al (2013) Correlation of staging systems to survival in patients with resected hilar cholangiocarcinoma. Am J Surg 206:159–165

    PubMed  Google Scholar 

  18. Burak K, Angulo P, Pasha TM, Egan K, Petz J, Lindor KD (2004) Incidence and risk factors for cholangiocarcinoma in primary sclerosing cholangitis. Am J Gastroenterol 99:523–526

    Article  PubMed  Google Scholar 

  19. Lazaridis KN, Gores GJ (2006) Primary sclerosing cholangitis and cholangiocarcinoma. Semin Liver Dis 26:42–51

    Article  PubMed  CAS  Google Scholar 

  20. Heimbach JK, Sanchez W, Rosen CB, Gores GJ (2011) Trans-peritoneal fine needle aspiration biopsy of hilar cholangiocarcinoma is associated with disease dissemination. HPB (Oxford) 13:356–360

    Article  Google Scholar 

  21. Gores GJ, Gish RG, Sudan D, Rosen CB (2006) Model for end-stage liver disease (MELD) exception for cholangiocarcinoma or biliary dysplasia. Liver Transpl 12:S95–S97

    Article  PubMed  Google Scholar 

  22. Darwish Murad S, Kim WR, Harnois DM et al (2012) Efficacy of neoadjuvant chemoradiation, followed by liver transplantation, for perihilar cholangiocarcinoma at 12 US centers. Gastroenterology 143:88–98

    Article  PubMed  Google Scholar 

  23. Rosen CB, Heimbach JK, Gores GJ (2010) Liver transplantation for cholangiocarcinoma. Transpl Int 23:692–697

    Article  PubMed  Google Scholar 

  24. Rea DJ, Rosen CB, Nagorney DM, Heimbach JK, Gores GJ (2009) Transplantation for cholangiocarcinoma: when and for whom? Surg Oncol Clin N Am 18:325–337

    Article  PubMed  Google Scholar 

  25. Heimbach JK, Gores GJ, Haddock MG et al (2004) Liver transplantation for unresectable perihilar cholangiocarcinoma. Semin Liver Dis 24:201–207

    Article  PubMed  Google Scholar 

  26. Mantel HT, Rosen CB, Heimbach JK et al (2007) Vascular complications after orthotopic liver transplantation after neoadjuvant therapy for hilar cholangiocarcinoma. Liver Transpl 13:1372–1381

    Article  PubMed  Google Scholar 

  27. Dodd GD 3rd, Memel DS, Zajko AB, Baron RL, Santaguida LA (1994) Hepatic artery stenosis and thrombosis in transplant recipients: Doppler diagnosis with resistive index and systolic acceleration time. Radiology 192:657–661

    PubMed  Google Scholar 

  28. Hom BK, Shrestha R, Palmer SL et al (2006) Prospective evaluation of vascular complications after liver transplantation: comparison of conventional and microbubble contrast-enhanced US. Radiology 241:267–274

    Article  PubMed  Google Scholar 

  29. Huang TL, Cheng YF, Chen TY et al (2010) Doppler ultrasound evaluation of postoperative portal vein stenosis in adult living donor liver transplantation. Transplant Proc 42:879–881

    Article  PubMed  CAS  Google Scholar 

  30. Duffy JP, Hong JC, Farmer DG et al (2009) Vascular complications of orthotopic liver transplantation: experience in more than 4,200 patients. J Am Coll Surg 208:896–903

    Article  PubMed  Google Scholar 

  31. Sommacale D, Aoyagi T, Dondero F et al (2013) Repeat endovascular treatment of recurring hepatic artery stenoses in orthotopic liver transplantation. Transpl Int 26:608–615

    Article  PubMed  CAS  Google Scholar 

  32. Rostambeigi N, Hunter D, Duval S, Chinnakotla S, Golzarian J (2013) Stent placement versus angioplasty for hepatic artery stenosis after liver transplant: a meta-analysis of case series. Eur Radiol 23:1323–1334

    Article  PubMed  Google Scholar 

  33. Saad WE, Dasgupta N, Lippert AJ et al (2013) Extrahepatic pseudoaneurysms and ruptures of the hepatic artery in liver transplant recipients: endovascular management and a new iatrogenic etiology. Cardiovasc Intervent Radiol 36:118–127

    Article  PubMed  Google Scholar 

  34. Ko GY, Sung KB, Yoon HK, Lee S (2007) Early posttransplantation portal vein stenosis following living donor liver transplantation: percutaneous transhepatic primary stent placement. Liver Transpl 13:530–536

    Article  PubMed  Google Scholar 

  35. Cheng YF, Ou HY, Tsang LL et al (2010) Vascular stents in the management of portal venous complications in living donor liver transplantation. Am J Transplant 10:1276–1283

    Article  PubMed  Google Scholar 

  36. Ko GY, Sung KB, Yoon HK et al (2002) Endovascular treatment of hepatic venous outflow obstruction after living-donor liver transplantation. J Vasc Interv Radiol 13:591–599

    Article  PubMed  Google Scholar 

  37. Darcy MD (2007) Management of venous outflow complications after liver transplantation. Tech Vasc Interv Radiol 10:240–245

    Article  PubMed  Google Scholar 

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Correspondence to Charles B. Rosen .

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© 2014 Springer-Verlag Berlin Heidelberg

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Zaydfudim, V.M., Nagorney, D.M., Rosen, C.B. (2014). Imaging of Hilar Cholangiocarcinoma for Liver Transplantation. In: Herman, J., Pawlik, T., Thomas, Jr., C. (eds) Biliary Tract and Gallbladder Cancer. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-40558-7_9

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  • DOI: https://doi.org/10.1007/978-3-642-40558-7_9

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  • Publisher Name: Springer, Berlin, Heidelberg

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  • Online ISBN: 978-3-642-40558-7

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