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Biliary Tract and Gallbladder Cancer pp 33–44Cite as

Role of Growth Factor Signaling Pathways in Biliary Tract Cancer

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Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

Biliary-tract carcinomas (BTCs) are relatively infrequent but highly lethal malignancies. Novel targets for therapeutic or chemopreventive approaches are urgently needed. However, the knowledge of genomic mutations in BTC is less extensive than that of other gastrointestinal cancers. In this chapter, we will discuss the role of growth factors and their receptors (receptor tyrosine kinases, RTKs), downstream signaling pathways of these RTKs and inflammatory mediators during gallbladder carcinogenesis based on our study using a mouse model for human BTC as well as additional information in the literature.

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Acknowledgments

The authors would like to thank Christie Nguyen and Lauren Pascale for technical assistance.

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Authors and Affiliations

  1. Dell Pediatric Research Institute, College of Pharmacy, The University of Texas at Austin, 1400 Barbara Jordan Blvd., Austin, TX, 78723, USA

    Kaoru Kiguchi & John DiGiovanni

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  1. Kaoru Kiguchi
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Correspondence to Kaoru Kiguchi .

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Editors and Affiliations

  1. Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore, Maryland, USA

    Joseph M. Herman

  2. Department of Surgery, Johns Hopkins Hospital, Baltimore, Maryland, USA

    Timothy M. Pawlik

  3. Department of Radiation Oncology, Oregon Health and Science University, Portland, Oregon, USA

    Charles R. Thomas, Jr.

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Kiguchi, K., DiGiovanni, J. (2014). Role of Growth Factor Signaling Pathways in Biliary Tract Cancer. In: Herman, J., Pawlik, T., Thomas, Jr., C. (eds) Biliary Tract and Gallbladder Cancer. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-40558-7_2

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