Abstract
Gallbladder (GB) cancer carries a dismal prognosis with a 5-year survival rate of less than 5 % for advanced disease. Only 20 % of GB cancers are detected at an early stage when the disease is confined to the gallbladder. Improvements in surgical techniques have resulted in improved outcomes. We clearly understand that surgery is the only hope for survival and can have an impact on the natural history of the disease. In this article, we will summarize the most recent data with regards to the surgical options. Accurate diagnosis based on imaging and pathological staging will help us achieve better results. We will conclude by providing an algorithm to manage GB cancer based on T-staging.
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References
American Cancer Society (2012) Cancer facts and figures 2012. Atlanta, Ga. [cited 2013 Jan 11]. Available from: http://www.cancer.org/acs/groups/content/@epidemiologysurveilance/documents/document/acspc-031941.pdf
North American Association of Central Cancer Registries (2013) CINA + Online Cancer in North America
American Cancer Society (2012) Survival statistics for gallbladder cancer, by stage. [cited 2013 Jan 14 2013]. Available from: http://www.cancer.org/cancer/gallbladdercancer/detailedguide/gallbladder-survival-rates
SEER (2013) Statistics stratified bt cancer site. [cited 2013 Feb 5 2013]. Available from: http://seer.cancer.gov/faststats/selections.php?#Output
Diehl AK (1983) Gallstone size and the risk of gallbladder cancer. JAMA 250(17):2323–2326
Towfigh S et al (2001) Porcelain gallbladder is not associated with gallbladder carcinoma. Am Surg 67(1):7–10
Jarnagin WR, Belghiti J, Blumgart LH (2012) Blumgart’s surgery of the liver, biliary tract, and pancreas. Available from: http://www.sciencedirect.com/science/book/9781437714548
Bobbs J (1868) Case of lithotomy of the gallbaldder. Trans Med Soc Indiana 18:68
Glenn F (1971) Biliary tract disease since antiquity. Bull N Y Acad Med 47(4):329–350
Hardy KJ (1993) Carl Langenbuch and the Lazarus Hospital: events and circumstances surrounding the first cholecystectomy. Aust N Z J Surg 63(1):56–64
Pack GT, Miller TR, Brasfield RD (1955) Total right hepatic lobectomy for cancer of the gallbladder; report of three cases. Ann Surg 142(1):6–16
Reynolds W Jr (2001) The first laparoscopic cholecystectomy. JSLS 5(1):89–94
Marescaux J et al (1998) Virtual reality applied to hepatic surgery simulation: the next revolution. Ann Surg 228(5):627–634
Satava RM (1999) Emerging technologies for surgery in the 21st century. Arch Surg 134(11):1197–1202
Bryan PJ et al (1977) Correlation of computed tomography, gray scale ultrasonography, and radionuclide imaging of the liver in detecting space-occupying processes. Radiology 124(2):387–393
Grossman ZD et al (1977) Radionuclide imaging, computed tomography, and gray-scale ultrasonography of the liver: a comparative study. J Nucl Med 18(4):327–332
Damadian R (1971) Tumor detection by nuclear magnetic resonance. Science 171(3976):1151–1153
Shih SP et al (2007) Gallbladder cancer: the role of laparoscopy and radical resection. Ann Surg 245(6):893–901
Sun CD et al (2005) Laparoscopic cholecystectomy for treatment of unexpected early-stage gallbladder cancer. J Surg Oncol 91(4):253–257
Kwon AH et al (2008) Unsuspected gallbladder cancer diagnosed during or after laparoscopic cholecystectomy. J Surg Oncol 97(3):241–245
Benson AB 3rd et al (2009) NCCN clinical practice guidelines in oncology: hepatobiliary cancers. J Natl Compr Canc Netw 7(4):350–391
Fong Y, Jarnagin W, Blumgart LH (2000) Gallbladder cancer: comparison of patients presenting initially for definitive operation with those presenting after prior noncurative intervention. Ann Surg 232(4):557–569
Miller G, Jarnagin WR (2008) Gallbladder carcinoma. Eur J Surg Oncol (EJSO) 34(3):306–312
Duffy A et al (2008) Gallbladder cancer (GBC): 10-year experience at Memorial Sloan-Kettering Cancer Centre (MSKCC). J Surg Oncol 98(7):485–489
de Aretxabala X et al (2006) Gallbladder cancer: an analysis of a series of 139 patients with invasion restricted to the subserosal layer. J Gastrointest Surg 10(2):186–192
You DD et al (2008) What is an adequate extent of resection for T1 gallbladder cancers? Ann Surg 247(5):835–838
Yamaguchi K, Tsuneyoshi M (1992) Subclinical gallbladder carcinoma. Am J Surg 163(4):382–386
Shirai Y et al (1992) Inapparent carcinoma of the gallbladder. An appraisal of a radical second operation after simple cholecystectomy. Ann Surg 215(4):326–331
Ouchi K, Mikuni J, Kakugawa Y (2002) Laparoscopic cholecystectomy for gallbladder carcinoma: results of a Japanese survey of 498 patients. J Hepatobiliary Pancreat Surg 9(2):256–260
Otero JC et al (2006) Gallbladder cancer: surgical results after cholecystectomy in 25 patients with lamina propria invasion and 26 patients with muscular layer invasion. J Hepatobiliary Pancreat Surg 13(6):562–566
Principe A et al (2006) Radical surgery for gallbladder carcinoma: possibilities of survival. Hepatogastroenterology 53(71):660–664
Tsukada K et al (1996) Outcome of radical surgery for carcinoma of the gallbladder according to the TNM stage. Surgery 120(5):816–821
Jensen EH et al (2009) A critical analysis of the surgical management of early-stage gallbladder cancer in the United States. J Gastrointest Surg 13(4):722–727
de Aretxabala X et al (2004) Management of gallbladder cancer with invasion of the muscular layer. Rev Med Chil 132(2):183–188
Ogura Y et al (1991) Radical operations for carcinoma of the gallbladder: present status in Japan. World J Surg 15(3):337–343
Konstantinidis IT et al. (2009) Trends in presentation and survival for gallbladder cancer during a period of more than 4 decades: a single-institution experience. Arch Surg 144(5): 441–447 (discussion 447)
de Aretxabala XA et al (1997) Curative resection in potentially resectable tumours of the gallbladder. Eur J Surg 163(6):419–426
Shirai Y et al (2012) Regional lymphadenectomy for gallbladder cancer: rational extent, technical details, and patient outcomes. World J Gastroenterol 18(22):2775–2783
Greene FL et al. (ed) (2010) AJCC Cancer Staging Handbook, 7th edn. American Joint Committee on Cancer, Chicago
Kondo S et al (2002) Extensive surgery for carcinoma of the gallbladder. Br J Surg 89(2):179–184
Piehler JM, Crichlow RW (1978) Primary carcinoma of the gallbladder. Surg Gynecol Obstet 147(6):929–942
Onoyama H et al (1995) Extended cholecystectomy for carcinoma of the gallbladder. World J Surg 19(5):758–763
Doty JR et al (2002) Cholecystectomy, liver resection, and pylorus-preserving pancreaticoduodenectomy for gallbladder cancer: report of five cases. J Gastrointest Surg 6(5):776–780
Nimura Y et al (1991) Hepatopancreatoduodenectomy for advanced carcinoma of the biliary tract. Hepatogastroenterology 38(2):170–175
Yang HL, Sun YG, Wang Z (1992) Polypoid lesions of the gallbladder: diagnosis and indications for surgery. Br J Surg 79(3):227–229
Konstantinidis IT et al (2012) Gallbladder lesions identified on ultrasound. Lessons from the last 10 years. J Gastrointest Surg 16(3):549–553
Pandey M et al (2000) Carcinoma of the gallbladder: role of sonography in diagnosis and staging. J Clin Ultrasound 28(5):227–232
Z’Graggen K et al (1998) Incidence of port site recurrence after laparoscopic cholecystectomy for preoperatively unsuspected gallbladder carcinoma. Surgery 124(5):831–838
Maker AV et al (2012) Is port site resection necessary in the surgical management of gallbladder cancer? Ann Surg Oncol 19(2):409–417
Suzuki K, Kimura T, Ogawa H (1998) Is laparoscopic cholecystectomy hazardous for gallbladder cancer? Surgery 123(3):311–314
Lundberg O, Kristoffersson A (2000) Wound recurrence from gallbladder cancer after open cholecystectomy. Surgery 127(3):296–300
Yamaguchi K et al (1996) Gallbladder carcinoma in the era of laparoscopic cholecystectomy. Arch Surg 131(9):981–984 discussion 985
Corvera CU, Weber SM, Jarnagin WR (2002) Role of laparoscopy in the evaluation of biliary tract cancer. Surg Oncol Clin N Am 11(4):877–891
Butte JM et al (2011) The role of laparoscopic staging in patients with incidental gallbladder cancer. HPB (Oxford) 13(7):463–472
Chijiiwa K et al (2001) Surgical treatment of patients with T2 gallbladder carcinoma invading the subserosal layer. J Am Coll Surg 192(5):600–607
Wakai T, Shirai Y, Hatakeyama K (2002) Radical second resection provides survival benefit for patients with T2 gallbladder carcinoma first discovered after laparoscopic cholecystectomy. World J Surg 26(7):867–871
Toyonaga T et al (2003) Completion radical surgery after cholecystectomy for accidentally undiagnosed gallbladder carcinoma. World J Surg 27(3):266–271
Foster JM et al (2007) Gallbladder cancer: Defining the indications for primary radical resection and radical re-resection. Ann Surg Oncol 14(2):833–840
Gall FP et al (1991) Radical operations for carcinoma of the gallbladder: present status in Germany. World J Surg 15(3):328–336
Nakamura S et al (1999) Outcome of extensive surgery for TNM stage IV carcinoma of the gallbladder. Hepatogastroenterology 46(28):2138–2143
D’Angelica M et al (2009) Analysis of the extent of resection for adenocarcinoma of the gallbladder. Ann Surg Oncol 16(4):806–816
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Pugalenthi, A., Fong, Y. (2014). Surgical Management of Gallbladder Cancer. In: Herman, J., Pawlik, T., Thomas, Jr., C. (eds) Biliary Tract and Gallbladder Cancer. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-40558-7_17
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DOI: https://doi.org/10.1007/978-3-642-40558-7_17
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