Skip to main content

Functional Imaging

  • Chapter
  • First Online:
Biliary Tract and Gallbladder Cancer

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

  • 1762 Accesses

Abstract

Positron Emission Tomography (PET) has been in clinical practice since early 1990s; however, widespread use was hampered due to non-availability of anatomical reference. In the late 1990s and early 2000s, with the advent of hybrid imaging, PET/computed tomography (CT), the oncological utilization has increased significantly. PET/CT has been shown to have high sensitivity and negative predictive value for the detection of tumors, with many studies reporting superior utility of PET/CT over conventional anatomical imaging such as CT, magnetic resonance imaging (MRI), and ultrasound. Despite limited literature regarding utilization of PET/CT in gall bladder and biliary tract cancer, the available literature studies provide evidence for the potential advantage of PET/CT in staging, restaging, and detecting recurrence of gallbladder and biliary tract cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Bailey D, Townsend PE, Valk MN (2005) Positron emission tomography: basic sciences 2005. Springer, Secaucus

    Book  Google Scholar 

  2. Wood K, Hoskin PJ, Saunders MI (2007) Positron emission tomography in oncology: a review. Clin Oncol 19:237–255

    Article  CAS  Google Scholar 

  3. Beuthien-Baumann B, Hamacher K, Oberdorfer F et al (2000) Preparation of fluorine-18 labelled sugars and derivatives and their application as tracer for positron-emission-tomography. Carbohydr Res 327(1–2):107–118

    Article  PubMed  CAS  Google Scholar 

  4. Warburg O, Wind F, Negelein E (1927) The metabolism of tumors in the body. J Gen Physiol 8(6):519–530

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  5. Kumar R, Halanaik D, Malhotra A (2010) Clinical applications of positron emission tomography-computed tomography in oncology. Indian J Cancer 47:100–119

    Article  PubMed  CAS  Google Scholar 

  6. Anderson H, Price P (2000) What does positron emission tomography offer oncology? Eur J Cancer 36:2028–2035

    Article  PubMed  CAS  Google Scholar 

  7. Lucignani G, Paganelli G, Bombardieri E (2004) The use of standardized uptake values for assessing FDG uptake with PET in oncology: a clinical perspective. Nucl Med Commun 25:651–656

    Article  PubMed  CAS  Google Scholar 

  8. Wahl R, Jacene H, Kasamon Y et al (2009) From RECIST to PERCIST: evolving considerations for PET response criteria in solid tumors. J Nucl Med 50(Suppl 1):122S–150S

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  9. Vriens D, Visser EP, Geus-Oei LF et al (2010) Methodological considerations in quantification of oncological FDG PET studies. Eur J Nucl Med Mol Imaging 37(7):1408–1425

    Article  PubMed Central  PubMed  Google Scholar 

  10. Lee S, Kim HJ, Park JH (2010) Clinical usefulness of 18F-FDG PET-CT for patients with gallbladder cancer and cholangiocarcinoma. J Gastroenterol 45:560–566

    Article  PubMed  Google Scholar 

  11. Rodrigues-Fernandez A, Gomez-Rio M, Llamas-Elvira JM et al (2004) Positron-emission tomography with fluorine-18F-FDG for gallbladder cancer diagnosis. Am J Surg 188:171–175

    Article  Google Scholar 

  12. Petrowsky H, Wildbrett P, Husarik DB et al (2006) Impact of integrated positron emission tomography and computed tomography on staging and management of gallbladder cancer and cholangiocarcinoma. J Hepatol 45:43–50

    Article  PubMed  Google Scholar 

  13. Yamada I, Ajiki T, Ueno K et al (2012) Feasibility of 18F-FDG PET for preoperative evaluation of biliary tract cancer. Anticancer Res 32(11):5105–5110

    PubMed  CAS  Google Scholar 

  14. Shukla P, Barreto SG, Arya S et al (2008) Does PET-CT scan have a role prior to radical re-resection for incidental gallbladder cancer? HPB 10:439–445

    Article  PubMed Central  PubMed  Google Scholar 

  15. Breitenstein S, Aperstegui C, Clavien PA (2008) Positron emission tomography (PET) for cholangiocarcinoma. HPB 10:120–121

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  16. Alkhawaldeh K, Faltten S, Biersack HJ et al (2011) The value of F-18 FDG PET in patients with primary sclerosing cholangitis and cholangiocarcinoma using visual and semiquantitative analysis. Clin Nucl Med 36(10):879–883

    Article  PubMed  Google Scholar 

  17. Corvera C, Blumgart LH, Akhurst T et al (2008) 18F-FDG PET influences management decisions in patients with biliary cancer. J Am Coll Surg 206:57–65

    Article  PubMed  Google Scholar 

  18. Kim J, Kim MH, Lee TY et al (2008) Clinical role of 18F-FDG PET-CT in suspected and potentially operable cholangiocarcinoma: a prospective study compared with conventional imaging. Am J Gastroenterol 103:1145–1151

    Article  PubMed  Google Scholar 

  19. Li J, Kuehl H, Grabellus F et al (2008) Preoperative assessment of hilar cholangiocarcinoma by dual-modality PET/CT. J Surg Oncol 98:438–443

    Article  PubMed  Google Scholar 

  20. Ruys A, Bennink RJ, van Westreenen HL et al (2011) FDG-positron emission tomography/computed tomography and standardized uptake value in the primary diagnosis and staging of hilar cholangiocarcinoma. HPB 134:256–262

    Article  Google Scholar 

  21. Kobayashi S, Nagano H, Hoshino H et al (2011) Diagnostic value of FDG-PET for lymph node metastasis and outcome of surgery for biliary cancer. J Surg Oncol 103(3):223–229

    Article  PubMed  Google Scholar 

  22. Cameron K, Golan S, Simpson W et al (2011) Recurrent pancreatic carcinoma and cholangiocarcinoma: 18F-FDG PET/CT. Abdom Imaging 36(4):463–471

    Article  PubMed  Google Scholar 

  23. Kitajima K, Murakami K, Kanagae K (2009) Clinical impact of whole body FDG-PET for recurrent biliary cancer: a multicenter study. Ann Nucl Med 23:709–715

    Article  PubMed  Google Scholar 

  24. Kumar R, Sharma P, Kumari A et al (2012) Role of 18F-FDG PET/CT in detecting recurrent gallbladder carcinoma. Clin Nucl Med 37(5):431–435

    Article  PubMed  Google Scholar 

  25. Jadvar H, Henderson RW, Conti PS (2007) 18F-FDG PET and PET:CT in recurrent and metastatic cholangiocarcinoma. J Comput Assist Tomogr 31(2):223–228

    Article  PubMed  Google Scholar 

  26. Lee Y, Han SW, Oh DY et al (2011) Diagnostic performance of contrast enhanced CT and 18F-FDG PET/CT in suspicious recurrence of biliary tract cancer after curative resection. BMC 11(1):188–195

    Google Scholar 

  27. Smith G, Carroll L, Aboagye EO (2012) New frontiers in the design and synthesis of imaging probes for PET oncology: current challenges and future directions. Mol Imaging Biol 14(6):653–666

    Article  PubMed  Google Scholar 

  28. Yankeelov T, Pererson TE, Abramson RG et al (2012) Simultaneous PET-MRI in oncology: a solution looking for a problem? Magn Reson Imaging 30:1342–1356

    Article  PubMed Central  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Richard L. Wahl .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Chaudhry, M.A., Kadhim, L.AR., Wahl, R.L. (2014). Functional Imaging. In: Herman, J., Pawlik, T., Thomas, Jr., C. (eds) Biliary Tract and Gallbladder Cancer. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-40558-7_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-40558-7_11

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-40557-0

  • Online ISBN: 978-3-642-40558-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics