Skip to main content
SpringerLink
Log in

Therapeutic Applications of Functionalized Conjugated Polyelectrolytes

  • Chapter
  • First Online:
Functionalized Conjugated Polyelectrolytes

Part of the book series: SpringerBriefs in Molecular Science ((BRIEFSMOLECULAR))

  • 882 Accesses

Abstract

Conjugated polyelectrolytes can be induced to generate reactive oxygen species upon light illumination, which act as photosensitizers in photodynamic therapy to damage pathogenic microorganisms and cancer cells. In this chapter, the light-activated biocidal activities of PPE derivatives are presented where PPE derivatives act as photosensitizers. A multifunctional cationic PPV 3 for simultaneously accomplishing selective recognition, imaging, and killing of bacteria over mammalian cells has been reported. Moreover, energy transfer systems have been illustrated to enhance light-activated antibacterial activity. CPEs are also exploited to function concurrently as an anticancer agent and an imaging reporter, and furthermore the anticancer specificity can be achieved through delicate molecular design. CPE-drug conjugates have been constructed for intracellular molecule-targeted binding and inactivation of protein for growth inhibition of cancer cells. Bioluminescence has been employed to replace light source in PDT through bioluminescence resonance energy transfer to conjugated polyelectrolytes, which opens a new therapy modality to tumor and pathogen infections.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Hamblin MR, Hasan T (2004) Photodynamic therapy: a new antimicrobial approach to infectious disease? Photochem Photobio Sci 3:436–450

    Article  CAS  Google Scholar 

  2. Kobayashi H, Ogawa M, Alford R, Choyke PL, Urano Y (2009) New strategies for fluorescent probe design in medical diagnostic imaging. Chem Rev 110:2620–2640

    Article  Google Scholar 

  3. Li P, Poon YF, Li W, Zhu H-Y, Yeap SH, Cao Y, Qi X, Zhou C, Lamrani M, Beuerman RW, Kang E-T, Mu Y, Li CM, Chang MW, Leong SSJ, Chan-Park MB (2011) A polycationic antimicrobial and biocompatible hydrogel with microbe membrane suctioning ability. Nat Mater 10:149–156

    Article  CAS  Google Scholar 

  4. Lu L, Rininsland FH, Wittenburg SK, Achyuthan KE, McBranch DW, Whitten DG (2005) Biocidal activity of a light-absorbing fluorescent conjugated polyelectrolyte. Langmuir 21:10154–10159

    Article  CAS  Google Scholar 

  5. Chemburu S, Corbitt TS, Ista LK, Ji E, Fulghum J, Lopez GP, Ogawa K, Schanze KS, Whitten DG (2008) Light-induced biocidal action of conjugated polyelectrolytes supported on colloids. Langmuir 24:11053–11062

    Article  CAS  Google Scholar 

  6. Corbitt TS, Ding L, Ji E, Ista LK, Ogawa K, Lopez GP, Schanze KS, Whitten DG (2009) Light and dark biocidal activity of cationic poly(arylene ethynylene) conjugated polyelectrolytes. Photochem Photobio Sci 8:998–1005

    Article  CAS  Google Scholar 

  7. Corbitt TS, Sommer JR, Chemburu S, Ogawa K, Ista LK, Lopez GP, Whitten DG, Schanze KS (2008) Conjugated polyelectrolyte capsules: light-activated antimicrobial micro “roach motels”. ACS Appl Mater Interfaces 1:48–52

    Article  Google Scholar 

  8. Zhou Z, Corbitt TS, Parthasarathy A, Tang Y, Ista LK, Schanze KS, Whitten DG (2010) “End-only” functionalized oligo(phenylene ethynylene)s: synthesis, photophysical and biocidal activity. J Phys Chem Lett 1:3207–3212

    Article  CAS  Google Scholar 

  9. Tang Y, Corbitt TS, Parthasarathy A, Zhou Z, Schanze KS, Whitten DG (2011) Light-induced antibacterial activity of symmetrical and asymmetrical oligophenylene ethynylenes. Langmuir 27:4956–4962

    Article  CAS  Google Scholar 

  10. Wang Y, Jett SD, Crum J, Schanze KS, Chi EY, Whitten DG (2012) Understanding the dark and light-enhanced bactericidal action of cationic conjugated polyelectrolytes and oligomers. Langmuir 29:781–792

    Article  CAS  Google Scholar 

  11. Ding L, Chi EY, Chemburu S, Ji E, Schanze KS, Lopez GP, Whitten DG (2009) Insight into the mechanism of antimicrobial poly(phenylene ethynylene) polyelectrolytes:interactions with phosphatidylglycerol lipid membranes. Langmuir 25:13742–13751

    Article  CAS  Google Scholar 

  12. Ding L, Chi EY, Schanze KS, Lopez GP, Whitten DG (2009) Insight into the mechanism of antimicrobial conjugated polyelectrolytes: lipid headgroup charge and membrane fluidity effects. Langmuir 26:5544–5550

    Article  Google Scholar 

  13. Wang Y, Tang Y, Zhou Z, Ji E, Lopez GP, Chi EY, Schanze KS, Whitten DG (2010) Membrane perturbation activity of cationic phenylene ethynylene oligomers and polymers: selectivity against model bacterial and mammalian membranes. Langmuir 26:12509–12514

    Article  CAS  Google Scholar 

  14. Wang Y, Chi EY, Natvig DO, Schanze KS, Whitten DG (2013) Antimicrobial activity of cationic conjugated polyelectrolytes and oligomers against saccharomyces cerevisiae vegetative cells and ascospores. ACS Appl Mater Interfaces 5:4555–4561

    Google Scholar 

  15. Zhu C, Yang Q, Liu L, Lv F, Li S, Yang G, Wang S (2011) Multifunctional cationic poly(p-phenylene vinylene) polyelectrolytes for selective recognition, imaging, and killing of bacteria over mammalian cells. Adv Mater 23:4805–4810

    Article  CAS  Google Scholar 

  16. Wu C, Xu Q-H (2009) Enhanced one- and two-photon excitation emission of a porphyrin photosensitizes by fret from a conjugated polyelectrolyte. Macromol Rapid Commun 30:504–508

    Article  CAS  Google Scholar 

  17. Zhang R-R, Li L, Tong L-L, Tang B (2013) Enhanced luminescence of photosensitizer-based mesoporous silica nanocomposites via energy transfer from conjugated polymer. Nanotechnology 24:015604–015604

    Google Scholar 

  18. Xing C, Xu Q, Tang H, Liu L, Wang S (2009) Conjugated polymer/porphyrin complexes for efficient energy transfer and improving light-activated antibacterial activity. J Am Chem Soc 131:13117–13124

    Article  CAS  Google Scholar 

  19. Xing C, Yang G, Liu L, Yang Q, Lv F, Wang S (2012) Conjugated polymers for light-activated antifungal activity. Small 8:525–529

    Article  CAS  Google Scholar 

  20. Liu L, Duan X, Liu H, Wang S, Li Y (2008) Microorganism-based assemblies of luminescent conjugated polyelectrolytes. Chem Commun 45:5999–6001

    Google Scholar 

  21. Liu L, Yu M, Duan X, Wang S (2010) Conjugated polymers as multifunctional biomedical platforms: Anticancer activity and apoptosis imaging. J Mater Chem 20:6942–6947

    Article  Google Scholar 

  22. Xing C, Liu L, Tang H, Feng X, Yang Q, Wang S, Bazan GC (2011) Design guidelines for conjugated polymers with light-activated anticancer activity. Adv Funct Mater 21:4058–4067

    Article  CAS  Google Scholar 

  23. Wang B, Yuan H, Zhu C, Yang Q, Lv F, Liu L, Wang S (2012) Polymer-drug conjugates for intracellar molecule-targeted photoinduced inactivation of protein and growth inhibition of cancer cells. Sci Rep 2:766

    Google Scholar 

  24. Salami S, Karami-Tehrani F (2003) Biochemical studies of apoptosis induced by tamoxifen in estrogen receptor positive and negative breast cancer cell lines. Clin Biochem 36:247–253

    Article  CAS  Google Scholar 

  25. Rickert EL, Trebley JP, Peterson AC, Morrell MM, Weatherman RV (2007) Synthesis and characterization of bioactive tamoxifen-conjugated polymers. Biomacromolecules 8:3608–3612

    Article  CAS  Google Scholar 

  26. Rivera-Guevara C, Perez-Alvarez V, Garcia-Becerra R, Ordaz-Rosado D, Sonia Morales-Rios M, Hernandez-Gallegos E, Cooney AJ, Elena Bravo-Gomez M, Larrea F, Camacho J (2010) Genomic action of permanently charged tamoxifen derivatives via estrogen receptor-alpha. Biorg Med Chem 18:5593–5601

    Article  CAS  Google Scholar 

  27. Zhu C, Yang Q, Lv F, Liu L, Wang S (2013) Conjugated polymer-coated bacteria for multimodal intracellular and extracellular anticancer activity. Adv Mater 25:1203–1208

    Article  CAS  Google Scholar 

  28. Yuan H, Chong H, Wang B, Zhu C, Liu L, Yang Q, Lv F, Wang S (2012) Chemical molecule-induced light-activated system for anticancer and antifungal activities. J Am Chem Soc 134:13184–13187

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Organic Solids Laboratory, Chinese Academy of Sciences Institute of Chemistry, Beijing, People’s Republic of China

    Shu Wang & Fengting Lv

Authors
  1. Shu Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Fengting Lv
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Shu Wang .

Rights and permissions

Reprints and permissions

Copyright information

© 2013 The Author(s)

About this chapter

Cite this chapter

Wang, S., Lv, F. (2013). Therapeutic Applications of Functionalized Conjugated Polyelectrolytes. In: Functionalized Conjugated Polyelectrolytes. SpringerBriefs in Molecular Science. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-40540-2_6

Download citation

Publish with us

Policies and ethics

Search

Navigation