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Functionalized Conjugated Polyelectrolytes pp 17–41Cite as

Diagnostic Applications of Functionalized Conjugated Polyelectrolytes

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Part of the book series: SpringerBriefs in Molecular Science ((BRIEFSMOLECULAR))

Abstract

In this chapter, the diagnostic applications of CPEs are illustrated from the following three aspects which are diagnostic sensors for disease-related biomarkers, diagnostics of microbial infection, and diagnostics of tumor. Förster resonance energy transfer (FRET) between PFP and fluorescein has been successfully utilized for detection of disease-related genes biomarkers, including DNA single nucleotide polymorphisms (SNPs), methylation, and mutation. The specific conformation-sensitive property of PDA and PT has been utilized to develop diagnostic methods toward bacteria and cancer cells. By taking advantages of signal amplification effect offered by CPEs, the concept of chemical nose/tongue has been employed for the detection and discrimination of proteins, bacteria, and discrimination between normal and cancer cells.

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Authors and Affiliations

  1. Organic Solids Laboratory, Chinese Academy of Sciences Institute of Chemistry, Beijing, People’s Republic of China

    Shu Wang

  2. Organic Solids Laboratory, Chinese Academy of Sciences Institute of Chemistry, Beijing, People’s Republic of China

    Fengting Lv

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  1. Shu Wang
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  2. Fengting Lv
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Correspondence to Shu Wang .

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Wang, S., Lv, F. (2013). Diagnostic Applications of Functionalized Conjugated Polyelectrolytes. In: Functionalized Conjugated Polyelectrolytes. SpringerBriefs in Molecular Science. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-40540-2_2

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