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The Therapeutic Use of Ayahuasca pp 41–58Cite as

Ayahuasca as a Candidate Therapy for PTSD

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Abstract

Posttraumatic stress disorder (PTSD) is a syndrome that affects a substantial portion of both the civilian and military populations, and is often underdiagnosed due to complications with delayed onset and co-occurring psychiatric disorders. The prevalence of this devastating disorder is growing as more people come forward with traumatic events in their past. It is crucial that we develop a more comprehensive diagnostic and therapeutic framework for PTSD in order to reduce harm and aid in long-term functional recovery. Currently accepted therapeutic options for PTSD are proving to be insufficient as increasing numbers of people present with treatment-resistant PTSD, and alternative avenues for diagnosis and treatment are currently being investigated to improve standards of patient care. This chapter focuses on the rationale for why ayahuasca may be successful in treating certain kinds of PTSD, and reviews the previously reported pathophysiology of PTSD and its current treatments, and the new, experimental therapies being explored. This chapter also proposes a novel method known as “syndromics ,” which aims to characterize the full syndrome of PTSD using bioinformatics and multivariate pattern detection, in the hopes that by understanding the full complexity of this syndrome, we will be able to identify more efficient therapeutic targets, such as ayahuasca, to cure it.

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References

  • American Psychological Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed., text rev.). Washington, D.C.: Author.

    Google Scholar 

  • Barker, S. A., McIlhenny, E. H., & Strassman, R. (2012). A critical review of reports of endogenous psychedelic N, N-dimethyltryptamines in humans: 1955–2010. Drug Testing and Analysis, 4(7–8), 617–635. doi:10.1002/dta.422.

    Article  CAS  PubMed  Google Scholar 

  • Blaustein, M., Cook, A., Cloitre, M., DeRosa, R., Ford, J., Henderson, M., et al. (2003). Complex trauma in children and adolescents: White paper from the National Child Traumatic Stress Network Complex Trauma Task Force. Retrieved June 18, 2013 from from http://www.nctsn.org/sites/default/files/assets/pdfs/ComplexTrauma_All.pdf.

  • Bouso, J. C., Doblin, R., Farre, M., Alcazar, M. A., & Gomez-Jarabo, G. (2008). MDMA-assisted psychotherapy using low doses in a small sample of women with chronic post-traumatic stress disorder. Journal of Psychoactive Drugs, 40(3), 225–236.

    Article  Google Scholar 

  • Brewin, C. R., Andrews, B., & Valentine, J. D. (2000). Meta-analysis of risk factors for post-traumatic stress disorder in trauma-exposed adults. Journal of Consulting and Clinical Psychology, 68(5), 748–766.

    Article  CAS  Google Scholar 

  • Callaway, J. C., Airaksinen, M. M., McKenna, D. J., Brito, G. S., & Grob, C. S. (1994). Platelet serotonin uptake sites increased in drinkers of ayahuasca. Psychopharmacology (Berl), 116(3), 385–387.

    Article  CAS  Google Scholar 

  • Caudle, K. L., Brown, E. H., Shum-Siu, A., Burke, D. A., Magnuson, T. S., Voor, M. J., et al. (2011). Hindlimb immobilization in a wheelchair alters functional recovery following contusive spinal cord injury in the adult rat. Neurorehabil Neural Repair, 25(8), 729–739. doi:10.1177/1545968311407519.

    Article  PubMed  PubMed Central  Google Scholar 

  • Dao, J., & Lehren, A. W. (2013, May 15). Baffling rise in suicides plagues the U.S. military. New York Times. Retrieved from http://www.nytimes.com/2013/05/16/us/baffling-rise-in-suicides-plagues-us-military.html.

  • de Araujo, D. B., Ribeiro, S., Cecchi, G. A., Carvalho, F. M., Sanchez, T. A., Pinto, J. P., et al. (2012). Seeing with the eyes shut: Neural basis of enhanced imagery following ayahuasca ingestion. Human Brain Mapping, 33(11), 2550−2560. doi: 10.1002/hbm.21381.

  • Dharmshaktu, P., Tayal, V., & Kalra, B. S. (2012). Efficacy of antidepressants as analgesics: A review. Journal of Clinical Pharmacology, 52(1), 6–17. doi:10.1177/0091270010394852.

    Article  CAS  PubMed  Google Scholar 

  • Dolan, E. W. (2011, May 16). Federal agency blocks FDA-approved marijuana research for veterans. Retrieved June 18, 2013 from http://www.rawstory.com/rs/2011/10/04/dept-of-health-and-human-services-blocks-fda-approved-marijuana-research-for-veterans/.

  • Dos Santos, R. G., Valle, M., Bouso, J. C., Nomdedeu, J. F., Rodriguez-Espinosa, J., McIlhenny, E. H., et al. (2011). Autonomic, neuroendocrine, and immunological effects of ayahuasca: A comparative study with d-amphetamine. Journal of Clinical Psychopharmacology, 31(6), 717–726. doi: 10.1097/JCP.0b013e31823607f6.

  • Drug Enforcement Administration. (2011). Drugs of abuse. Retrieved June 18, 2013 from http://www.justice.gov/dea/docs/drugs_of_abuse_2011.pdf.

  • Engel, G. L. (1977). The need for a new medical model: A challenge for biomedicine. Science, 196(4286), 129–136.

    Article  CAS  Google Scholar 

  • Erowid. (2012). Ayahuasca reports. Retrieved June 18, 2013 from http://www.erowid.org/experiences/subs/exp_Ayahuasca.shtml.

  • Erowid. (2013, 4/25/13). Ayahuasca fatalities/deaths. Retrieved June 18, 2013 from http://www.erowid.org/chemicals/ayahuasca/ayahuasca_death.shtml.

  • Feinberg, J. (2013). Wordle. Retrieved May 20, 2013 from http://www.wordle.net/.

  • Ferguson, A. R., Huie, J. R., Crown, E. D., Baumbauer, K. M., Hook, M. A., Garraway, S. M. et al. (2012a). Maladaptive spinal plasticity opposes spinal learning and recovery in spinal cord injury. Frontiers in Physiology, 3, 399. doi: 10.3389/fphys.2012.00399.

  • Ferguson, A. R., Huie, J. R., Crown, E. D., & Grau, J. W. (2012b). Central nociceptive sensitization vs. spinal cord training: Opposing forms of plasticity that dictate function after complete spinal cord injury. Frontiers in Physiology, 3, 396. doi: 10.3389/fphys.2012.00396.

  • Ferguson, A. R., Irvine, K. A., Gensel, J. C., Nielson, J. L., Lin, A., Ly, J., et al. (2013). Derivation of multivariate syndromic outcome metrics for consistent testing across multiple models of cervical spinal cord injury in rats. PLoS One, 8(3), e59712. doi: 10.1371/journal.pone.0059712.

  • Ferguson, A. R., Stuck, E. D., & Nielson, J. L. (2011). Syndromics: A bioinformatics approach for neurotrauma research. Translational Stroke Research, 2(4), 438–454.

    Article  Google Scholar 

  • Gould, M., Greenberg, N., & Hetherton, J. (2007). Stigma and the military: Evaluation of a PTSD psychoeducational program. Journal of Traumatic Stress, 20(4), 505–515. doi:10.1002/jts.20233.

    Article  PubMed  Google Scholar 

  • Grau, J. W., Huie, J. R., Garraway, S. M., Hook, M. A., Crown, E. D., Baumbauer, K. M., et al. (2012). Impact of behavioral control on the processing of nociceptive stimulation. Frontiers in Physiology, 3, 262. doi: 10.3389/fphys.2012.00262.

  • Grau, J. W., Hyson, R. L., Maier, S. F., Madden, J. T., & Barchas, J. D. (1981). Long-term stress-induced analgesia and activation of the opiate system. Science, 213(4514), 1409–1411.

    Article  CAS  Google Scholar 

  • Hains, B. C., Everhart, A. W., Fullwood, S. D., & Hulsebosch, C. E. (2002). Changes in serotonin, serotonin transporter expression, and serotonin denervation supersensitivity: Involvement in chronic central pain after spinal hemisection in the rat. Experimental Neurology, 175(2), 347–362. doi:10.1006/exnr.2002.7892.

    Article  CAS  PubMed  Google Scholar 

  • Johnson, S. L. (2009). Therapist’s guide to posttraumatic stress disorder intervention (1st ed.). London: Academic Press.

    Google Scholar 

  • Jones, T., & Moller, M. D. (2011). Implications of hypothalamic-pituitary-adrenal axis functioning in posttraumatic stress disorder. Journal of the American Psychiatric Nurses Association, 17(6), 393–403. doi:10.1177/1078390311420564.

    Article  PubMed  Google Scholar 

  • Kaloupek, D. G., Chard, K. M., Freed, M. C., Peterson, A. L., Riggs, D. S., Stein, M. B., et al. (2010). Common data elements for posttraumatic stress disorder research. Archives of Physical Medicine and Rehabilitation, 91(11), 1684–1691. doi:10.1016/j.apmr.2010.06.032.

    Article  PubMed  Google Scholar 

  • Leary, T. (1966). Programmed communication during experiences with DMT. Psychedelic Review, 8, 83–95.

    Google Scholar 

  • Ledford, H. (2013). Psychiatry framework seeks to reform diagnostic doctrine. Advance online publication. Nature. doi: 10.1038/nature.2013.12972.

  • Levine, P. A., & Frederick, A. (1997). Waking the tiger: Healing trauma. Berkeley, CA: North Atlantic Books.

    Google Scholar 

  • Lewis, T., Amini, F., & Lannon, R. (2000). A general theory of love. New York, NY: Vintage Books.

    Google Scholar 

  • Longo, L. P., & Johnson, B. (2000). Addiction: Part I. Benzodiazepines—side effects, abuse risk, and alternatives. American Family Physician, 61(7), 2121–2128.

    CAS  PubMed  Google Scholar 

  • Longo, L. P., Parran, T, Jr, Johnson, B., & Kinsey, W. (2000). Addiction: Part II. Identification and management of the drug-seeking patient. American Family Physician, 61(8), 2401–2408.

    CAS  PubMed  Google Scholar 

  • Lyalka, V. F., Hsu, L. J., Karayannidou, A., Zelenin, P. V., Orlovsky, G. N., & Deliagina, T. G. (2011). Facilitation of postural limb reflexes in spinal rabbits by serotonergic agonist administration, epidural electrical stimulation, and postural training. Journal of Neurophysiology, 106(3), 1341–1354. doi:10.1152/jn.00115.2011.

    Article  CAS  PubMed  Google Scholar 

  • McKay, K. M., Imel, Z. E., & Wampold, B. E. (2006). Psychiatrist effects in the psychopharmacological treatment of depression. Journal of Affective Disorders, 92(2–3), 287–290. doi:10.1016/j.jad.2006.01.020.

    Article  PubMed  Google Scholar 

  • McKenna, D. J. (2004). Clinical investigations of the therapeutic potential of ayahuasca: Rationale and regulatory challenges. Pharmacology & Therapeutics, 102(2), 111–129. doi:10.1016/j.pharmthera.2004.03.002.

    Article  CAS  Google Scholar 

  • Mithoefer, M. C., Wagner, M. T., Mithoefer, A. T., Jerome, L., & Doblin, R. (2011). The safety and efficacy of {±}3,4-methylenedioxymethamphetamine-assisted psychotherapy in subjects with chronic, treatment-resistant post-traumatic stress disorder: The first randomized controlled pilot study. Journal of Psychopharmacology, 25(4), 439–452. doi:10.1177/0269881110378371.

    Article  CAS  PubMed  Google Scholar 

  • Mithoefer, M. C., Wagner, M. T., Mithoefer, A. T., Jerome, L., Martin, S. F., Yazar-Klosinski, B., et al. (2013). Durability of improvement in post-traumatic stress disorder symptoms and absence of harmful effects or drug dependency after 3,4-methylenedioxymethamphetamine-assisted psychotherapy: A prospective long-term follow-up study. Journal of Psychopharmacology, 27(1), 28−39. doi: 10.1177/0269881112456611.

  • Multidisciplinary Association for Psychedelic Studies. (2013). MDMA-assisted psychotherapy. Research. Retrieved May 18, 2013 from http://www.maps.org/research/mdma/.

  • Murphy, S. E. (2010). Using functional neuroimaging to investigate the mechanisms of action of selective serotonin reuptake inhibitors (SSRIs). Current Pharmaceutical Design, 16(18), 1990–1997.

    Article  CAS  Google Scholar 

  • Murrough, J. W., Huang, Y., Hu, J., Henry, S., Williams, W., Gallezot, J. D., et al. (2011). Reduced amygdala serotonin transporter binding in post-traumatic stress disorder. Biological Psychiatry, 70(11), 1033−1038. doi: 10.1016/j.biopsych.2011.07.003.

  • National Institute of Mental Health. (2011). Research Domain Criteria (RDoC). Retrieved June 18, 2013 from http://www.nimh.nih.gov/research-funding/rdoc/nimh-research-domain-criteria-rdoc.shtml#toc_product.

  • Neumeister, A., Normandin, M. D., Pietrzak, R. H., Piomelli, D., Zheng, M. Q., Gujarro-Anton, A. (2013). Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: A positron emission tomography study. Advance online publication. Molecular Psychiatry. doi: 10.1038/mp.2013.61.

  • Oehen, P., Traber, R., Widmer, V., & Schnyder, U. (2013). A randomized, controlled pilot study of MDMA (+/− 3,4-Methylenedioxymethamphetamine)-Assisted psychotherapy for treatment of resistant, chronic post-traumatic stress disorder (PTSD). Journal of Psychopharmacology, 27(1), 40–52. doi:10.1177/0269881112464827.

    Article  CAS  PubMed  Google Scholar 

  • Petty, F., Kramer, G., & Wilson, L. (1992). Prevention of learned helplessness: In vivo correlation with cortical serotonin. Pharmacology, Biochemistry and Behavior, 43(2), 361–367.

    Article  CAS  Google Scholar 

  • Prigerson, H. G., Maciejewski, P. K., & Rosenheck, R. A. (2002). Population attributable fractions of psychiatric disorders and behavioral outcomes associated with combat exposure among US men. American Journal of Public Health, 92(1), 59–63.

    Article  Google Scholar 

  • Riba, J., Rodriguez-Fornells, A., & Barbanoj, M. J. (2002). Effects of ayahuasca on sensory and sensorimotor gating in humans as measured by P50 suppression and prepulse inhibition of the startle reflex, respectively. Psychopharmacology (Berl), 165(1), 18–28. doi:10.1007/s00213-002-1237-5.

    Article  CAS  Google Scholar 

  • Riba, J., Romero, S., Grasa, E., Mena, E., Carrio, I., & Barbanoj, M. J. (2006). Increased frontal and paralimbic activation following ayahuasca, the pan-Amazonian inebriant. Psychopharmacology (Berl), 186(1), 93–98. doi:10.1007/s00213-006-0358-7.

    Article  CAS  Google Scholar 

  • Saladin, M. E., Brady, K. T., Dansky, B. S., & Kilpatrick, D. G. (1995). Understanding comorbidity between PTSD and substance use disorders: Two preliminary investigations. Addictive Behaviors, 20(5), 643–655.

    Article  CAS  Google Scholar 

  • Shepherd, J. D., & Bear, M. F. (2011). New views of Arc, a master regulator of synaptic plasticity. Nature Neuroscience, 14(3), 279–284. doi:10.1038/nn.2708.

    Article  CAS  PubMed  Google Scholar 

  • Stein, M. B., McQuaid, J. R., Pedrelli, P., Lenox, R., & McCahill, M. E. (2000). Post-traumatic stress disorder in the primary care medical setting. General Hospital Psychiatry, 22(4), 261.

    Article  CAS  Google Scholar 

  • Stickgold, R. (2002). EMDR: A putative neurobiological mechanism of action. Journal of Clinical Psychology, 58(1), 61–75.

    Article  Google Scholar 

  • Terr, L. (1990). Too scared to cry: How trauma affects children and ultimately us all. New York, NY: Basic Books.

    Google Scholar 

  • Thomas, G., Lucas, P., Capler, N. R., Tupper, K. W., & Martin, G. (2013). Ayahuasca-assisted therapy for addiction: Results from a preliminary observational study in Canada. Advance online publication. Current Drug Abuse Reviews. 6(1):30–42

    Google Scholar 

  • United States, & United States Drug Enforcement Administration, Office of Chief Counsel. (1996). Controlled Substances Act as amended to February 15, 1996. Washington, D. C.: U.S. Dept. of Justice, Drug Enforcement Administration, Office of Chief Counsel.

    Google Scholar 

  • Ursano, R. J., Bell, C., Eth, S., Friedman, M., Norwood, A., Pfefferbaum, B. (2004). Practice guideline for the treatment of patients with acute stress disorder and post-traumatic stress disorder. American Journal of Psychiatry, 161(11 Suppl), 3−31.

    Google Scholar 

  • van der Kolk, B., Greenberg, M., Boyd, H., & Krystal, J. (1985). Inescapable shock, neurotransmitters, and addiction to trauma: Toward a psychobiology of post-traumatic stress. Biological Psychiatry, 20(3), 314–325.

    Article  Google Scholar 

  • Wang, D., & Sun, T. (2011). Neural plasticity and functional recovery of human central nervous system with special reference to spinal cord injury. Spinal Cord, 49(4), 486–492. doi:10.1038/sc.2010.124.

    Article  CAS  PubMed  Google Scholar 

  • Yehuda, R. (2002). Post-traumatic stress disorder. New England Journal of Medicine, 346(2), 108–114. doi:10.1056/NEJMra012941.

    Article  CAS  Google Scholar 

  • Zimmerman, M., & Mattia, J. I. (1999). Is post-traumatic stress disorder underdiagnosed in routine clinical settings? The Journal of Nervous and Mental Disease, 187(7), 420–428.

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Neurological Surgery, University of California, San Francisco, 1001 Potrero Avenue, Building 1, Room 101, San Francisco, CA, 94110, USA

    Jessica L. Nielson

  2. The Well Clinic, San Francisco, CA, USA

    Julie D. Megler

Authors
  1. Jessica L. Nielson
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  2. Julie D. Megler
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Correspondence to Jessica L. Nielson .

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Editors and Affiliations

  1. Center for Economic Research and Education (CIDE), Aguascalientes, AGS, Mexico

    Beatriz Caiuby Labate

  2. Nucleus for Interdisciplinary Studies of Psychoactives (NEIP), San Francisco, CA, USA

    Clancy Cavnar

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Nielson, J.L., Megler, J.D. (2014). Ayahuasca as a Candidate Therapy for PTSD. In: Labate, B.C., Cavnar, C. (eds) The Therapeutic Use of Ayahuasca. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-40426-9_3

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