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Targeting NMDA Receptors in Epilepsy

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Pathologies of Calcium Channels

Abstract

N-methyl-D-aspartate receptors (NMDARs) are one of the most widely-studied receptors in the central nervous system (CNS). These receptors mediate Ca2+ influx into the neurons and play pivotal roles in the pathophysiology of many neurological diseases including epilepsy. Animal models of seizure and status epilepticus and clinical studies have indicated that NMDAR functioning can be altered during epilepsy and thereafter in some specific types of seizure. Different classes of NMDAR antagonists also have antiepileptic effects in both clinical and preclinical studies, although some contradictory effects in both preclinical and clinical studies have been reported. In this book chapter, we review the evidence for the involvement of NMDARs in the pathophysiology of epilepsy and provide an overview of NMDAR antagonists being investigated in clinical trials and animal models of seizure.

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  1. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA

    Mehdi Ghasemi

  2. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Ahmad Reza Dehpour

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  1. Hotchkiss Brain Institute, Department of Physiology and Pharmacology, University of Calgary, Calgary, Canada

    Norbert Weiss

  2. Department of Neurophysiology and Pharmacology, Medical University Vienna, Vienna, Austria

    Alexandra Koschak

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Ghasemi, M., Dehpour, A.R. (2014). Targeting NMDA Receptors in Epilepsy. In: Weiss, N., Koschak, A. (eds) Pathologies of Calcium Channels. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-40282-1_32

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