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Pharmacology of TRPV Channels

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Pathologies of Calcium Channels

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Abstract

From a pharmacological point of view, the transient receptor potential (TRPV) family of ion channels are interesting drug targets. After the identification of the TRPV1 channel, an attractive candidate for analgesic intervention, many agonists and antagonists were generated. Although TRPV1 modifying drugs partially induce serious side effects, several efforts are still under development. There is growing evidence that also the other thermo-gated TRPs are promising drug targets. Most interestingly, mutations within the TRPV4 gene are causing many skeletal dysplasias underlining the importance of the function of this ion channel. Another interesting channel, TRPV6, was shown to be up-regulated in a few malignancies including breast and prostate cancer. Several data show that the overexpression of TRPV6 contributes to an aggressive cancel cell phenotype.

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  1. Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Universität des Saarlandes, 66421, Homburg/Saar, Germany

    Ulrich Wissenbach

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  1. Hotchkiss Brain Institute, Department of Physiology and Pharmacology, University of Calgary, Calgary, Canada

    Norbert Weiss

  2. Department of Neurophysiology and Pharmacology, Medical University Vienna, Vienna, Austria

    Alexandra Koschak

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Wissenbach, U. (2014). Pharmacology of TRPV Channels. In: Weiss, N., Koschak, A. (eds) Pathologies of Calcium Channels. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-40282-1_27

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