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TRP Channels in Prostate Cancer

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Pathologies of Calcium Channels

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Abstract

TRP channels are often associated with sensory roles, but they also participate in such critical cellular processes as apoptosis, proliferation and differentiation. Disregulation of normal TRP channel activity and associated changes in calcium homeostasis often leads to disruption of normal cell cycle and, as a result, onset and progression of cancer. While early evidence specific to prostate cancer stemmed from studies involving blockers of voltage-gated calcium channels, later studies identified multiple TRP channels that appear to be at the center of prostate cancer progression. This chapter discusses the involvement of TRP channels in regulation of cell fate in prostate tissues, focusing on the prominent players belonging to TRPC, TRPM, and TRPV families as well as giving a general overview of the roles that TRP channels play in prostate cancer.

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Acknowledgments

This work was supported by grants from INSERM, la Ligue Nationale Contre le Cancer, le Ministere de l‘Education Nationale, the Region Nord/Pas-de-Calais. George Shapovalov was supported by grant from FRM.

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  1. Inserm U1003, Equipe Labellisee par la Ligue Nationale Contre le Cancer, Laboratory of Excellence Ion Channels Sciences and Therapeutics, Universite de Sciences et Technologies de Lille (USTL), 59655, Villeneuve dAscq, France

    George Shapovalov, Roman Skryma & Natalia Prevarskaya

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  1. George Shapovalov
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  2. Roman Skryma
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Correspondence to George Shapovalov .

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  1. Hotchkiss Brain Institute, Department of Physiology and Pharmacology, University of Calgary, Calgary, Canada

    Norbert Weiss

  2. Department of Neurophysiology and Pharmacology, Medical University Vienna, Vienna, Austria

    Alexandra Koschak

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Shapovalov, G., Skryma, R., Prevarskaya, N. (2014). TRP Channels in Prostate Cancer. In: Weiss, N., Koschak, A. (eds) Pathologies of Calcium Channels. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-40282-1_26

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