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Pathologies of Calcium Channels pp 225–238Cite as

Brugada Syndrome and Voltage-Gated Calcium Channels

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Abstract

Brugada Syndrome is an inherited disease affecting ion channels of the heart leading to arrhythmia and sudden cardiac death. Brugada Syndrome typically manifests in middle age men after or during periods of rest, with the vast majority of sudden death occurring in individuals without structural heart defects. Cardiac ion channel dysfunction in Brugada Syndrome is well recognized; however, how voltage-gated calcium channel genes, specifically CACNA1C, CACNB2b, and CACNA2D1 are implicated, is a recent development. This chapter addresses why VGCCs are important for the ventricular action potential and how Brugada Syndrome is visualized on ECG, in particular the two types of elevated ST segments commonly used for clinical diagnosis. We also examine voltage-gated calcium channel mutations linked to Brugada Syndrome and how specific mutations cause a loss-of-function of the channel complex.

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References

  • Altier C, Garcia-Caballero A, Simms B, You H, Chen L, Walcher J, Tedford HW, Hermosilla T, Zamponi GW (2011) The Cavbeta subunit prevents RFP2-mediated ubiquitination and proteasomal degradation of L-type channels. Nat Neurosci 14 (2):173-180

    Article  PubMed  CAS  Google Scholar 

  • Antzelevitch C, Brugada P, Borggrefe M, Brugada J, Brugada R, Corrado D, Gussak I, LeMarec H, Nademanee K, Perez Riera AR, Shimizu W, Schulze-Bahr E, Tan H, Wilde A (2005) Brugada syndrome: report of the second consensus conference. Heart Rhythm 2 (4):429-440

    Article  PubMed  Google Scholar 

  • Antzelevitch C, Fish JM (2006) Therapy for the Brugada syndrome. Handb Exp Pharmacol (171):305-330

    Article  PubMed  CAS  Google Scholar 

  • Antzelevitch C, Pollevick GD, Cordeiro JM, Casis O, Sanguinetti MC, Aizawa Y, Guerchicoff A, Pfeiffer R, Oliva A, Wollnik B, Gelber P, Bonaros EP, Jr., Burashnikov E, Wu Y, Sargent JD, Schickel S, Oberheiden R, Bhatia A, Hsu LF, Haissaguerre M, Schimpf R, Borggrefe M, Wolpert C (2007) Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death. Circulation 115 (4):442-449

    Article  PubMed  Google Scholar 

  • Barajas-Martinez H, Hu D, Ferrer T, Onetti CG, Wu Y, Burashnikov E, Boyle M, Surman T, Urrutia J, Veltmann C, Schimpf R, Borggrefe M, Wolpert C, Ibrahim BB, Sanchez-Chapula JA, Winters S, Haissaguerre M, Antzelevitch C (2012) Molecular genetic and functional association of Brugada and early repolarization syndromes with S422L missense mutation in KCNJ8. Heart Rhythm 9 (4):548-555

    Article  PubMed  Google Scholar 

  • Barhanin J, Lesage F, Guillemare E, Fink M, Lazdunski M, Romey G (1996) K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current. Nature 384 (6604):78-80

    Article  PubMed  CAS  Google Scholar 

  • Bayes de Luna A, Brugada J, Baranchuk A, Borggrefe M, Breithardt G, Goldwasser D, Lambiase P, Riera AP, Garcia-Niebla J, Pastore C, Oreto G, McKenna W, Zareba W, Brugada R, Brugada P (2012) Current electrocardiographic criteria for diagnosis of Brugada pattern: a consensus report. J Electrocardiol 45 (5):433-442

    Article  PubMed  Google Scholar 

  • Beeler GW, Reuter H (1977) Reconstruction of the action potential of ventricular myocardial fibres. J Physiol 268 (1):177-210

    PubMed  CAS  Google Scholar 

  • Benitah JP, Alvarez JL, Gomez AM (2010) L-type Ca(2 +) current in ventricular cardiomyocytes. J Mol Cell Cardiol 48 (1):26-36

    Article  PubMed  CAS  Google Scholar 

  • Bennett PB, Yazawa K, Makita N, George AL, Jr. (1995) Molecular mechanism for an inherited cardiac arrhythmia. Nature 376 (6542):683-685

    Article  PubMed  CAS  Google Scholar 

  • Berne P, Brugada J (2012) Brugada syndrome 2012. Circ J 76 (7):1563-1571

    Article  PubMed  CAS  Google Scholar 

  • Bichet D, Cornet V, Geib S, Carlier E, Volsen S, Hoshi T, Mori Y, De Waard M (2000) The I-II loop of the Ca2 + channel alpha1 subunit contains an endoplasmic reticulum retention signal antagonized by the beta subunit. Neuron 25 (1):177-190

    Article  PubMed  CAS  Google Scholar 

  • Brahmi N, Thabet H, Kouraichi N, Driss I, Amamou M (2007) [Brugada syndrome and other cardiovascular abnormalities related to tricyclic antidepressants ans related drugs intoxication]. Arch Mal Coeur Vaiss 100 (1):28-33

    PubMed  CAS  Google Scholar 

  • Brugada P, Brugada J (1992) Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. J Am Coll Cardiol 20 (6):1391-1396

    Article  PubMed  CAS  Google Scholar 

  • Buraei Z, Yang J (2010) The Beta subunit of voltage-gated Ca2 + channels. Physiol Rev 90 (4):1461-1506

    Article  PubMed  CAS  Google Scholar 

  • Burashnikov E, Pfeiffer R, Barajas-Martinez H, Delpon E, Hu D, Desai M, Borggrefe M, Haissaguerre M, Kanter R, Pollevick GD, Guerchicoff A, Laino R, Marieb M, Nademanee K, Nam GB, Robles R, Schimpf R, Stapleton DD, Viskin S, Winters S, Wolpert C, Zimmern S, Veltmann C, Antzelevitch C (2010) Mutations in the cardiac L-type calcium channel associated with inherited J-wave syndromes and sudden cardiac death. Heart Rhythm 7 (12):1872-1882

    Article  PubMed  Google Scholar 

  • Catterall WA (2000) Structure and regulation of voltage-gated Ca2 + channels. Annu Rev Cell Dev Biol 16:521-555

    Article  PubMed  CAS  Google Scholar 

  • Chinushi M, Iijima K, Tagawa M, Komura S, Furushima H, Aizawa Y (2009) Effects of verapamil on anterior ST segment and ventricular fibrillation cycle length in patients with Brugada syndrome. J Electrocardiol 42 (4):367-373

    Article  PubMed  Google Scholar 

  • Chinushi M, Tagawa M, Nakamura Y, Aizawa Y (2006) Shortening of the ventricular fibrillatory intervals after administration of verapamil in a patient with Brugada syndrome and vasospastic angina. J Electrocardiol 39 (3):331-335

    Article  PubMed  Google Scholar 

  • Clatot J, Ziyadeh-Isleem A, Maugenre S, Denjoy I, Liu H, Dilanian G, Hatem SN, Deschenes I, Coulombe A, Guicheney P, Neyroud N (2012) Dominant-negative effect of SCN5A N-terminal mutations through the interaction of Nav1.5 alpha-subunits. Cardiovasc Res

    Google Scholar 

  • Cohen NM, Lederer WJ (1987) Calcium current in isolated neonatal rat ventricular myocytes. J Physiol 391:169-191

    PubMed  CAS  Google Scholar 

  • Cordeiro JM, Marieb M, Pfeiffer R, Calloe K, Burashnikov E, Antzelevitch C (2009) Accelerated inactivation of the L-type calcium current due to a mutation in CACNB2b underlies Brugada syndrome. J Mol Cell Cardiol 46 (5):695-703

    Article  PubMed  CAS  Google Scholar 

  • Dafi O, Berrou L, Dodier Y, Raybaud A, Sauve R, Parent L (2004) Negatively charged residues in the N-terminal of the AID helix confer slow voltage dependent inactivation gating to Cav1.2. Biophys J 87 (5):3181-3192

    Article  PubMed  CAS  Google Scholar 

  • Darbar D, Yang T, Churchwell K, Wilde AA, Roden DM (2005) Unmasking of brugada syndrome by lithium. Circulation 112 (11):1527-1531

    Article  PubMed  Google Scholar 

  • Delpon E, Cordeiro JM, Nunez L, Thomsen PE, Guerchicoff A, Pollevick GD, Wu Y, Kanters JK, Larsen CT, Hofman-Bang J, Burashnikov E, Christiansen M, Antzelevitch C (2008) Functional effects of KCNE3 mutation and its role in the development of Brugada syndrome. Circ Arrhythm Electrophysiol 1 (3):209-218

    Article  PubMed  CAS  Google Scholar 

  • Dulhunty AF (2006) Excitation-contraction coupling from the 1950s into the new millennium. Clin Exp Pharmacol Physiol 33 (9):763-772

    Article  PubMed  CAS  Google Scholar 

  • Erickson MG, Alseikhan BA, Peterson BZ, Yue DT (2001) Preassociation of calmodulin with voltage-gated Ca(2 +) channels revealed by FRET in single living cells. Neuron 31 (6):973-985

    Article  PubMed  CAS  Google Scholar 

  • Fang K, Colecraft HM (2011) Mechanism of auxiliary β-subunit-mediated membrane targeting of L-type (Cav1.2) channels. J Physiol

    Google Scholar 

  • Fish JM, Antzelevitch C (2004) Role of sodium and calcium channel block in unmasking the Brugada syndrome. Heart Rhythm 1 (2):210-217

    Article  PubMed  Google Scholar 

  • Fowler SJ, Priori SG (2009) Clinical spectrum of patients with a Brugada ECG. Curr Opin Cardiol 24 (1):74-81

    Article  PubMed  Google Scholar 

  • Giudicessi JR, Ye D, Tester DJ, Crotti L, Mugione A, Nesterenko VV, Albertson RM, Antzelevitch C, Schwartz PJ, Ackerman MJ (2011) Transient outward current (I(to)) gain-of-function mutations in the KCND3-encoded Kv4.3 potassium channel and Brugada syndrome. Heart Rhythm 8 (7):1024-1032

    Article  PubMed  Google Scholar 

  • Goldberger E (1946) Significance of downward T waves in precordial leads of normal children. Am J Dis Child 71:618-621

    PubMed  CAS  Google Scholar 

  • Heinemann SH, Terlau H, Stuhmer W, Imoto K, Numa S (1992) Calcium channel characteristics conferred on the sodium channel by single mutations. Nature 356 (6368):441-443

    Article  PubMed  CAS  Google Scholar 

  • Hermida JS, Lemoine JL, Aoun FB, Jarry G, Rey JL, Quiret JC (2000) Prevalence of the brugada syndrome in an apparently healthy population. Am J Cardiol 86 (1):91-94

    Article  PubMed  CAS  Google Scholar 

  • Herzig S, Khan IF, Grundemann D, Matthes J, Ludwig A, Michels G, Hoppe UC, Chaudhuri D, Schwartz A, Yue DT, Hullin R (2007) Mechanism of Ca(v)1.2 channel modulation by the amino terminus of cardiac beta2-subunits. Faseb J 21 (7):1527-1538

    Article  PubMed  CAS  Google Scholar 

  • Hess P, Lansman JB, Nilius B, Tsien RW (1986) Calcium channel types in cardiac myocytes: modulation by dihydropyridines and beta-adrenergic stimulation. J Cardiovasc Pharmacol 8 Suppl 9:S11-21

    PubMed  CAS  Google Scholar 

  • Hu D, Barajas-Martinez H, Burashnikov E, Springer M, Wu Y, Varro A, Pfeiffer R, Koopmann TT, Cordeiro JM, Guerchicoff A, Pollevick GD, Antzelevitch C (2009) A mutation in the beta 3 subunit of the cardiac sodium channel associated with Brugada ECG phenotype. Circ Cardiovasc Genet 2 (3):270-278

    Article  PubMed  CAS  Google Scholar 

  • Hu D, Barajas-Martinez H, Nesterenko VV, Pfeiffer R, Guerchicoff A, Cordeiro JM, Curtis AB, Pollevick GD, Wu Y, Burashnikov E, Antzelevitch C (2010) Dual variation in SCN5A and CACNB2b underlies the development of cardiac conduction disease without Brugada syndrome. Pacing Clin Electrophysiol 33 (3):274-285

    Article  PubMed  Google Scholar 

  • Hussain M, Orchard CH (1997) Sarcoplasmic reticulum Ca2 + content, L-type Ca2 + current and the Ca2 + transient in rat myocytes during beta-adrenergic stimulation. J Physiol 505 (Pt 2):385-402

    Article  PubMed  CAS  Google Scholar 

  • Kanter RJ, Pfeiffer R, Hu D, Barajas-Martinez H, Carboni MP, Antzelevitch C (2011) Brugada-like syndrome in infancy presenting with rapid ventricular tachycardia and intraventricular conduction delay. Circulation 125 (1):14-22

    Article  PubMed  Google Scholar 

  • Keung EC, Karliner JS (1990) Complex regulation of calcium current in cardiac cells. Dependence on a pertussis toxin-sensitive substrate, adenosine triphosphate, and an alpha 1-adrenoceptor. J Clin Invest 85 (3):950-954

    Article  PubMed  CAS  Google Scholar 

  • Kobrinsky E, Tiwari S, Maltsev VA, Harry JB, Lakatta E, Abernethy DR, Soldatov NM (2005) Differential role of the alpha1C subunit tails in regulation of the Cav1.2 channel by membrane potential, beta subunits, and Ca2 + ions. J Biol Chem 280 (13):12474-12485

    Article  PubMed  CAS  Google Scholar 

  • Lamelas P, Labadet C, Spernanzoni F, Saubidet CL, Alvarez PA (2012) Brugada electrocardiographic pattern induced by fever. World J Cardiol 4 (3):84-86

    Article  PubMed  Google Scholar 

  • Levi R, DeFelice LJ (1986) Sodium-conducting channels in cardiac membranes in low calcium. Biophys J 50 (1):5-9

    Article  PubMed  CAS  Google Scholar 

  • Littmann L, Monroe MH, Svenson RH (2000) Brugada-type electrocardiographic pattern induced by cocaine. Mayo Clin Proc 75 (8):845-849

    Article  PubMed  CAS  Google Scholar 

  • Lopez-Barbeito B, Lluis M, Delgado V, Jimenez S, Diaz-Infante E, Nogue-Xarau S, Brugada J (2005) Diphenhydramine overdose and Brugada sign. Pacing Clin Electrophysiol 28 (7):730-732

    Article  PubMed  Google Scholar 

  • McGregor M, Chen J (2004) Should the implantable cardiac defibrillator be used for primary prevention of sudden death? A review of the issues relevant to hospital decision making. Can J Cardiol 20 (12):1199-1204

    PubMed  Google Scholar 

  • Miyasaka Y, Tsuji H, Yamada K, Tokunaga S, Saito D, Imuro Y, Matsumoto N, Iwasaka T (2001) Prevalence and mortality of the Brugada-type electrocardiogram in one city in Japan. J Am Coll Cardiol 38 (3):771-774

    Article  PubMed  CAS  Google Scholar 

  • Miyazaki T, Mitamura H, Miyoshi S, Soejima K, Aizawa Y, Ogawa S (1996) Autonomic and antiarrhythmic drug modulation of ST segment elevation in patients with Brugada syndrome. J Am Coll Cardiol 27 (5):1061-1070

    Article  PubMed  CAS  Google Scholar 

  • Nakamura TY, Artman M, Rudy B, Coetzee WA (1998) Inhibition of rat ventricular IK1 with antisense oligonucleotides targeted to Kir2.1 mRNA. Am J Physiol 274 (3 Pt 2):H892-900

    Google Scholar 

  • Napolitano C, Antzelevitch C (2011) Phenotypical manifestations of mutations in the genes encoding subunits of the cardiac voltage-dependent L-type calcium channel. Circ Res 108 (5):607-618

    Article  PubMed  CAS  Google Scholar 

  • Ogawa M, Kumagai K, Yamanouchi Y, Saku K (2005) Spontaneous onset of ventricular fibrillation in Brugada syndrome with J wave and ST-segment elevation in the inferior leads. Heart Rhythm 2 (1):97-99

    Article  PubMed  Google Scholar 

  • Petit-Jacques J, Bois P, Bescond J, Lenfant J (1993) Mechanism of muscarinic control of the high-threshold calcium current in rabbit sino-atrial node myocytes. Pflugers Arch 423 (1-2):21-27

    Article  PubMed  CAS  Google Scholar 

  • Pitt GS, Zuhlke RD, Hudmon A, Schulman H, Reuter H, Tsien RW (2001) Molecular basis of calmodulin tethering and Ca2 + -dependent inactivation of L-type Ca2 + channels. J Biol Chem 276 (33):30794-30802

    Article  PubMed  CAS  Google Scholar 

  • Probst V, Veltmann C, Eckardt L, Meregalli PG, Gaita F, Tan HL, Babuty D, Sacher F, Giustetto C, Schulze-Bahr E, Borggrefe M, Haissaguerre M, Mabo P, Le Marec H, Wolpert C, Wilde AA (2010) Long-term prognosis of patients diagnosed with Brugada syndrome: Results from the FINGER Brugada Syndrome Registry. Circulation 121 (5):635-643

    Article  PubMed  CAS  Google Scholar 

  • Riera AR, Zhang L, Uchida AH, Schapachnik E, Dubner S, Ferreira C (2007) The management of Brugada syndrome patients. Cardiol J 14 (1):97-106

    PubMed  Google Scholar 

  • Rivera-Ruiz M, Cajavilca C, Varon J (2008) Einthoven’s string galvanometer: the first electrocardiograph. Tex Heart Inst J 35 (2):174-178

    PubMed  Google Scholar 

  • Rizzuto R, Pozzan T (2003) When calcium goes wrong: genetic alterations of a ubiquitous signaling route. Nat Genet 34 (2):135-141

    Article  PubMed  CAS  Google Scholar 

  • Romey G, Garcia L, Rieger F, Lazdunski M (1988) Targets for calcium channel blockers in mammalian skeletal muscle and their respective functions in excitation-contraction coupling. Biochem Biophys Res Commun 156 (3):1324-1332

    Article  PubMed  CAS  Google Scholar 

  • Rook MB, Bezzina Alshinawi C, Groenewegen WA, van Gelder IC, van Ginneken AC, Jongsma HJ, Mannens MM, Wilde AA (1999) Human SCN5A gene mutations alter cardiac sodium channel kinetics and are associated with the Brugada syndrome. Cardiovasc Res 44 (3):507-517

    Article  PubMed  CAS  Google Scholar 

  • Rook MB, Evers MM, Vos MA, Bierhuizen MF (2012) Biology of cardiac sodium channel Nav1.5 expression. Cardiovasc Res 93 (1):12-23

    Article  PubMed  CAS  Google Scholar 

  • Sacher F, Meregalli P, Veltmann C, Field ME, Solnon A, Bru P, Abbey S, Jais P, Tan HL, Wolpert C, Lande G, Bertault V, Derval N, Babuty D, Lacroix D, Boveda S, Maury P, Hocini M, Clementy J, Mabo P, Lemarec H, Mansourati J, Borggrefe M, Wilde A, Haissaguerre M, Probst V (2008) Are women with severely symptomatic brugada syndrome different from men? J Cardiovasc Electrophysiol 19 (11):1181-1185

    Article  PubMed  Google Scholar 

  • Sanguinetti MC, Jiang C, Curran ME, Keating MT (1995) A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. Cell 81 (2):299-307

    Article  PubMed  CAS  Google Scholar 

  • Shimizu W (2005) Acquired forms of the Brugada syndrome. J Electrocardiol 38 (4 Suppl):22-25

    Article  PubMed  Google Scholar 

  • Simms BA, Zamponi GW (2012) The Brugada syndrome mutation A39 V does not affect surface expression of neuronal rat Cav1.2 channels. Mol Brain 5:9

    Article  CAS  Google Scholar 

  • Sinner MF, Pfeufer A, Perz S, Schulze-Bahr E, Monnig G, Eckardt L, Beckmann BM, Wichmann HE, Breithardt G, Steinbeck G, Fabritz L, Kaab S, Kirchhof P (2009) Spontaneous Brugada electrocardiogram patterns are rare in the German general population: results from the KORA study. Europace 11 (10):1338-1344

    Article  PubMed  Google Scholar 

  • Skinner JR, Chung SK, Montgomery D, McCulley CH, Crawford J, French J, Rees MI (2005) Near-miss SIDS due to Brugada syndrome. Arch Dis Child 90 (5):528-529

    Article  PubMed  CAS  Google Scholar 

  • Suzuki M, Shiroshita-Takeshita A, Kuruihara T, Takatsuki S, Satoh T, Sato Y, Fukuda K, Hori S (2012) Fever-induced ST-segment elevation in a syncopal patient with Brugada syndrome. Am J Emerg Med 30 (1):263 e261-265

    Google Scholar 

  • Tsuchiya T, Ashikaga K, Honda T, Arita M (2002) Prevention of ventricular fibrillation by cilostazol, an oral phosphodiesterase inhibitor, in a patient with Brugada syndrome. J Cardiovasc Electrophysiol 13 (7):698-701

    Article  PubMed  Google Scholar 

  • Vatta M, Dumaine R, Antzelevitch C, Brugada R, Li H, Bowles NE, Nademanee K, Brugada J, Brugada P, Towbin JA (2002a) Novel mutations in domain I of SCN5A cause Brugada syndrome. Mol Genet Metab 75 (4):317-324

    Article  PubMed  CAS  Google Scholar 

  • Vatta M, Dumaine R, Varghese G, Richard TA, Shimizu W, Aihara N, Nademanee K, Brugada R, Brugada J, Veerakul G, Li H, Bowles NE, Brugada P, Antzelevitch C, Towbin JA (2002b) Genetic and biophysical basis of sudden unexplained nocturnal death syndrome (SUNDS), a disease allelic to Brugada syndrome. Hum Mol Genet 11 (3):337-345

    Article  PubMed  CAS  Google Scholar 

  • Viatchenko-Karpinski S, Gyorke S (2001) Modulation of the Ca(2 +)-induced Ca(2 +) release cascade by beta-adrenergic stimulation in rat ventricular myocytes. J Physiol 533 (Pt 3):837-848

    Article  PubMed  CAS  Google Scholar 

  • Watanabe H, Koopmann TT, Le Scouarnec S, Yang T, Ingram CR, Schott JJ, Demolombe S, Probst V, Anselme F, Escande D, Wiesfeld AC, Pfeufer A, Kaab S, Wichmann HE, Hasdemir C, Aizawa Y, Wilde AA, Roden DM, Bezzina CR (2008) Sodium channel beta1 subunit mutations associated with Brugada syndrome and cardiac conduction disease in humans. J Clin Invest 118 (6):2260-2268

    PubMed  CAS  Google Scholar 

  • Weissgerber P, Held B, Bloch W, Kaestner L, Chien KR, Fleischmann BK, Lipp P, Flockerzi V, Freichel M (2006) Reduced cardiac L-type Ca2 + current in Ca(V)beta2-/- embryos impairs cardiac development and contraction with secondary defects in vascular maturation. Circ Res 99 (7):749-757

    Article  PubMed  CAS  Google Scholar 

  • Wilde AA, Brugada R (2011) Phenotypical manifestations of mutations in the genes encoding subunits of the cardiac sodium channel. Circ Res 108 (7):884-897

    Article  PubMed  CAS  Google Scholar 

  • Yan GX, Antzelevitch C (1999) Cellular basis for the Brugada syndrome and other mechanisms of arrhythmogenesis associated with ST-segment elevation. Circulation 100 (15):1660-1666

    Article  PubMed  CAS  Google Scholar 

  • Yang J, Ellinor PT, Sather WA, Zhang JF, Tsien RW (1993) Molecular determinants of Ca2 + selectivity and ion permeation in L-type Ca2 + channels. Nature 366 (6451):158-161

    Article  PubMed  CAS  Google Scholar 

  • Yatani A, Wakamori M, Mikala G, Bahinski A (1993) Block of transient outward-type cloned cardiac K + channel currents by quinidine. Circ Res 73 (2):351-359

    Article  PubMed  CAS  Google Scholar 

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  1. Department of Physiology and Pharmacology, Hotchkiss Brain Institute, university of Calgary, Calgary, Canada

    Brett Simms

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  1. Hotchkiss Brain Institute, Department of Physiology and Pharmacology, University of Calgary, Calgary, Canada

    Norbert Weiss

  2. Department of Neurophysiology and Pharmacology, Medical University Vienna, Vienna, Austria

    Alexandra Koschak

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Simms, B. (2014). Brugada Syndrome and Voltage-Gated Calcium Channels. In: Weiss, N., Koschak, A. (eds) Pathologies of Calcium Channels. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-40282-1_12

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