DNA Self-Assembled Nanostructures for Resonance Energy Transfer Circuits

Abstract

This chapter describes our work toward building a molecular-scale integrated circuit technology based on DNA self-assembly. Distinct from its purpose in biology, we co-opt DNA to fold nanoscale substrates onto which we pattern optically active molecules into networks, or circuits. Unlike conventional computing paradigms founded on the principles of electron currents in metals and semiconductors, we employ a quantum mechanical transport mechanism called resonance energy transfer (RET) to convey signals. However, circuits of any interest for computing have been difficult to demonstrate due to an enormous design space with many, many degrees of freedom. To overcome this challenge we have developed a methodology for the design of RET circuits implemented on DNA nanostructures. First, we describe the general principles of RET circuits and DNA self-assembly, our design methodology, and then we conclude with two working examples to highlight the potential of this new technology.