DNA Self-Assembled Nanostructures for Resonance Energy Transfer Circuits

  • Chris DwyerEmail author
  • Arjun Rallapalli
  • Mohammad Mottaghi
  • Siyang Wang
Part of the Nano-Optics and Nanophotonics book series (NON)


This chapter describes our work toward building a molecular-scale integrated circuit technology based on DNA self-assembly. Distinct from its purpose in biology, we co-opt DNA to fold nanoscale substrates onto which we pattern optically active molecules into networks, or circuits. Unlike conventional computing paradigms founded on the principles of electron currents in metals and semiconductors, we employ a quantum mechanical transport mechanism called resonance energy transfer (RET) to convey signals. However, circuits of any interest for computing have been difficult to demonstrate due to an enormous design space with many, many degrees of freedom. To overcome this challenge we have developed a methodology for the design of RET circuits implemented on DNA nanostructures. First, we describe the general principles of RET circuits and DNA self-assembly, our design methodology, and then we conclude with two working examples to highlight the potential of this new technology.


Resonance Energy Transfer Design Rule Design Flow Physical Simulation Candidate Network 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    C. Pistol, C. Dwyer, A.R. Lebeck, Micro. IEEE 28, 7 (2008)Google Scholar
  2. 2.
    H.M. Watrob, C.-P. Pan, M.D. Barkley, J. Am. Chem. Soc. 125, 7336 (2003)CrossRefGoogle Scholar
  3. 3.
    D. Bystranowska, B. Siejda, A. Oyhar, M. Kochman, Biophys. Chem. 170, 1 (2012)CrossRefGoogle Scholar
  4. 4.
    C. Pistol, C. Dwyer, Nanotechnology 18, 125305 (2007)ADSCrossRefGoogle Scholar
  5. 5.
  6. 6.
    T. Frster, Ann. Phys. 437, 55 (1948)CrossRefGoogle Scholar
  7. 7.
  8. 8.
    BD Fluorescence Spectrum Viewer: A Multicolor Tool, (BD Biosciences)
  9. 9.
    C. Boswell, U. Utzinger, Spectra Database hosted at the University of Arizona,
  10. 10.
    H. Zhu, V. May, B. Rder, Chem. Phys. 351, 117 (2008)ADSCrossRefGoogle Scholar
  11. 11.
    J. Kowalewski, L. Mäler, in: Nuclear Spin Relaxation in Liquids, 1st edn. (Taylor & Francis, UK, 2006), pp. 65–95Google Scholar
  12. 12.
    J. Megow, B. Rder, A. Kulesza, V. Bonai-Kouteck, V. May, ChemPhysChem 12, 645 (2011)CrossRefGoogle Scholar
  13. 13.
    T. Renger, I. Trostmann, C. Theiss, M.E. Madjet, M. Richter, H. Paulsen, H.J. Eichler, A. Knorr, G. Renger, J. Phys. Chem. B 111, 10487 (2007)CrossRefGoogle Scholar
  14. 14.
    A. Shabani, M. Mohseni, H. Rabitz, S. Lloyd, Phys. Rev. E 86, 11915 (2012)ADSCrossRefGoogle Scholar
  15. 15.
    A.A. Demidov, in: Resonance Energy Transfer, 1st edn. (John Wiley & Sons Ltd, New York, 1999), pp. 435–65Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Chris Dwyer
    • 1
    Email author
  • Arjun Rallapalli
    • 1
  • Mohammad Mottaghi
    • 1
  • Siyang Wang
    • 1
  1. 1.Duke UniversityDurhamUS

Personalised recommendations