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The Use of Platelet-Rich Plasma in Orthopaedic Injuries

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Platelet-Rich Plasma

Part of the book series: Lecture Notes in Bioengineering ((LNBE))

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Abstract

This chapter brings a detailed review on the cell components in plasma, and their associated functions like haemostasis and inflammation, as well as the mechanism of platelet activation. The issue is described in a didactic and comprehensive format. The authors also include practical applications of PRP in orthopaedic diseases such as tendinopathies, chondral lesions, osteonecrosis and ACL lesions. The association of PRP, growth factors and mesenchymal stem cells is pointed out as a future treatment for orthopaedic lesions.

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References

  • Ahlback S, Bauer GCH, Bohne WH (1968) Spontaneous osteonecrosis of the knee. Arthritis Rheum 11:705–733

    Article  Google Scholar 

  • Anitua E (1999) Plasma rich in growh factors: preliminary results of use in the preparation of future sites for implants. Int J Oral Maxilofac Implants Lombard 14:529–535

    Google Scholar 

  • Basil J, Alwattar MD, Schwarzkopf R, Kirsch T (2011) Stem cells in orthopaedics and fracture healing. Bull NYU Hosp Jt Dis 69(1):6–10

    Google Scholar 

  • Centeno CJ, Faulkner S (2011) The use of mesenchymal stem cells in orthopedics: review of the literature, current research, and regulatory landscape. J Am Phys Surg 16(2):38–44

    Google Scholar 

  • Chen L, Dong SW, Liu JP, Tao X, Tang KL, Xu JZ (2012) Synergy of tendon stem cells and platelet-rich plasma in tendon healing. J Orthop Res 30(6):991–997. doi:10.1002/jor.22033

    Article  Google Scholar 

  • Deie M, Ochi M, Ikuta Y (1995) High intrinsic healing potential of human anterior cruciate ligament. Acta Orthop Scand 66:28–32

    Article  Google Scholar 

  • Dong Z, Li B, Liu B, Bai S, Li G, Ding A, Zhao J, Liu Y (2012) Platelet-rich plasma promotes angiogenesis of prefabricated vascular bone graft. J Oral Maxilofac 70(9):2191–2197

    Article  Google Scholar 

  • Eriksson E (2005) Do we need to perform double-bundle anterior cruciate ligament reconstructions? Oper Tech Orthop 15:4

    Article  Google Scholar 

  • Farng E, Hunt SA, Rose DJ, Sherman OH (2005) Anterior cruciate ligament radiofrequency thermal shrinkage: a short-term follow-up. Arthroscopy 21(9):1027–1033

    Article  Google Scholar 

  • Ganio C, Tenewitz FE, Wilson RC, Moyles BG (1993) The treatment of chronic nonhealing wounds using autologous platelet-derived growth factors. J Foot Ankle Surg 32(3):236–237

    Google Scholar 

  • Heilmeyser L, Begemann H (2002) Atlas Colorido de Hematologia. Revinter, Rio de Janeiro

    Google Scholar 

  • Jo CH, Kim JE, Yoon KS, Shin S (2012) Platelet-rich plasma stimulates cell proliferation and enhances matrix gene expression and synthesis in tenocytes from human rotator cuff tendons with degenerative tears. Am J Sports Med 40(5):1035–1045

    Article  Google Scholar 

  • Kenichi O, Taketoshi K et al (2011) New strategies for anterior cruciate ligament partial rupture using bone marrow transplantation in rats. Stem Cells Dev 20(4):671–679

    Article  Google Scholar 

  • Koga H, Muneta T, Ju YJ, Nagase T, Nimura T, Mochizuki T, Ichinose S, von der Mark K, Sekiya I (2007) Synovial stem cells are regionally specified according to local microenvironments after implantation for cartilage regeneration. Stem Cells 25:689–696

    Article  Google Scholar 

  • Kuroda R, Kurosaka M, Yoshiya S, Mizuno K (2000) Localization of growth factors in the reconstructed anterior cruciate ligament: immunohistological study in dogs. Knee Surg Sports Traumatol Arthrosc 8:120–126

    Article  Google Scholar 

  • Lee J, Harwood FL, Akeson WH, Amiel D (1998) Growth factor expression in healing rabbit medial collateral and anterior cruciate ligaments. Iowa Orthop J 18:19–25

    Google Scholar 

  • Linch SE, Williams RC, Polson AM, Howell TH, Reddy MS, Zappa UE, Antoniades HN (1989) A combination of platelets-derived and insulin-like growth factores enhances periodontal regeneration. J Clin Periodontol 16:545–548

    Article  Google Scholar 

  • Lorenzi TF (2003) Manual de Hematologia Propedêutica e Clínica, 3rd edn. Medsi, São Paulo

    Google Scholar 

  • Marx RE (1999) Platelet-rich plasma: a source of multiple autologous growth factors for bone grafts. Tissue engeneering. Application maxilofacial surgery and periodontics. Quintessence Books, IIIinois, pp 71–82

    Google Scholar 

  • Marx RE (2000) Platelet concentrate: a strategy for accelerating and improving bone regeneration. In: Davies JE (ed) Special chapter reprint from bone engineering, EM Squared, Inc

    Google Scholar 

  • Mast BA, Schultz GS, Gainesvillc (2000) Growth factors and plastic surgery. J Flórida 86:2–67

    Google Scholar 

  • Matsuda N, Lin WL, Kumar NM, Cho MI, Genco RJ (1992) Mitogenic, chemeotactic, and synthetic responses of rat períodontal ligament fibroblastic cells to polypeptide growth factors in vitro. J Periodontol 63(6):515–525

    Article  Google Scholar 

  • Mogan C, Larson DF (2004) Rationale of platelet gel to augment adaptive remodeling of the injured heart. J Am Soc Extra-Corporeal Technol JECT 36:191–196

    Google Scholar 

  • Nell A, Riegle B, Ulm C, Matejka M, Sinzinger H (1995) Stimulation der Plattchenmitogen-induzierten prostaglandin I2 synthese in periodontalen Gewebe von cyclosporine, A behandelten Patienten. Wien Klin Wochensschr 107(9):278–282

    Google Scholar 

  • Pascarella A, Liguori L, di Salvatore M, Latte C, Lanella G (2007) Treatment of articular cartilage lesions in the knee by perforations, stem cells and ‘autologous matrix induced chondrogenesis’: preliminary results. ICRS, Warsaw

    Google Scholar 

  • Peerbooms JC, Sluimer J, Bruijn DJ, Gosens T (2010) Positive effect of an autologous platelet concentrate in lateral epicondylitis in a double-blind. randomized controlled trial: platelet-rich plasma versus corticosteroid injection with a 1-year. Am J Sports Med 38:255. doi:10.1177/0363546509355445

    Article  Google Scholar 

  • Pontual MAB, Magini RS (2004) Plasma Rico em Plaquetas PRP e Fatores de Crescimento das Pesquisas Científicas à Clínica Odontológica. Ed. Santos, SP

    Google Scholar 

  • Rank F, Eiken O, Bergenholtz A, Lundborg G, Erkel LJ (1980) Flexor tendon specimens in organ cultures. Scand J Plast Reconstr Surg 14:179–183

    Article  Google Scholar 

  • Ripamontiu U, Reddi AH (1994) Periodontal regeneration: potencial role of boné morphogenetic proteins. J Periodontal Res 29:225–235

    Article  Google Scholar 

  • Rosen V, Thies RS (1992) The BMP proteins in bone formation and repair. Trends Genet 8(3):97–102

    Article  Google Scholar 

  • Rudkin GH, Miller TA (1996) Growth factors in surgery. Growth Factors 97(2):183–189

    Google Scholar 

  • Spindler KP, Murray MM, Carey JL, Zurakowski D, Fleming BC (2009) The use of platelets to affect functional healing of an anterior cruciate ligament (ACL) autograft in a caprine ACL reconstruction model. J Orthop Res 27:631–638

    Article  Google Scholar 

  • Sumner DR, Turner TM, Purchio AF et al (1995) Enhancement of bone ingrowth by transforming growth factor-beta. J Bone Joint Surg (Am) 77:1135–1147

    Google Scholar 

  • Petersen W, Zantop T (2006) Partial rupture of the anterior cruciate ligament. J Arthroscopic Relat Surg 22(11):1143–1145

    Article  Google Scholar 

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Correspondence to C. H. Bittencourt .

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Bittencourt, C.H., Bittencourt, P.B., Neto, O.A.L., Arenas, G.C.F. (2014). The Use of Platelet-Rich Plasma in Orthopaedic Injuries. In: Lana, J., Andrade Santana, M., Dias Belangero, W., Malheiros Luzo, A. (eds) Platelet-Rich Plasma. Lecture Notes in Bioengineering. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-40117-6_16

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  • DOI: https://doi.org/10.1007/978-3-642-40117-6_16

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-40116-9

  • Online ISBN: 978-3-642-40117-6

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