Acute Kidney Injury in the Newborn

  • Jennifer G. JettonEmail author
  • David Askenazi


Acute kidney injury (AKI) is characterized by a sudden impairment in kidney function that results in the inability to maintain adequate fluid, electrolyte, and waste product homeostasis. It is increasingly recognized as a common and significant event for newborns cared for in the neonatal intensive care unit, with important implications for treatment decisions and clinical outcomes. Indeed, AKI is associated with mortality in critically ill children [2, 86] and adults [14, 25, 52, 65, 78], even after controlling for medical comorbidities, severity of illness scores, and patient demographics. Emerging data suggest a similar association in the neonatal population as well [32, 47, 48], such that kidney injury can no longer be viewed as an incidental finding but rather an important determinant of patient outcomes.


Renal Replacement Therapy Acute Kidney Injury Fluid Overload Renal Hypoperfusion Nephrotoxic Medication 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Angiotensin-converting enzyme inhibitor


Acute tubular necrosis


Acute kidney injury


Blood urea nitrogen


Congenital anomalies of the kidney and urinary tract


Continuous venovenous hemodi-afiltration


Extracorporeal membrane oxygen-ation


Fractional excretion of sodium


Glomerular filtration rate










Milliequivalents per deciliter


Milligrams per deciliter




Neutrophil-gelatinase-associated lipocalin


Neonatal intensive care unit


Nonsteroidal anti-inflammatory drugs


Serum creatinine


Very low birth weight


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© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Division of Nephrology, Dialysis and Transplantation, Department of PediatricsUniversity of Iowa Children’s HospitalIowa CityUSA
  2. 2.Division of Pediatric NephrologyUniversity of Alabama at BirminghamBirminghamUSA

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