Zusammenfassung
Die Therapie des Urothelkarzinoms des oberen Harntraktes hängt in erster Linie vom Stadium und vom Grading ab. Eine Heilung lässt sich primär nur durch die chirurgische Entfernung erreichen. Zusätzlich können je nach Befund andere Methoden, wie Chemotherapie oder Radiatio adjuvant oder neoadjuvant, notwendig werden. Urothelkarzinome des oberen Harntraktes (UTUC) machen etwa 8–10 % der Urothelkarzinome aus, und damit ist die Behandlung der metastasierten Erkrankung weitgehend aus den Behandlungsparadigmen des metastasierten Blasenkarzinoms extrapoliert. Ein multimodaler Ansatz für das Management von fortgeschrittenen Erkrankungen ist oft erforderlich, einschließlich Chemotherapie, Strahlentherapie, Salvage-Operation, Metastatektomie und Palliativversorgung. Trotz eines solchen Ansatzes sind metastasierende UTUC selten heilbar, und somit besteht ein großer Bedarf für neue Ansätze und Therapeutika.
Die Therapie des Urothelkarzinoms des oberen Harntraktes (UTUC) hängt in erster Linie vom Stadium und vom Grading ab. Eine Heilung lässt sich primär nur durch die chirurgische Entfernung erreichen. Zusätzlich können je nach Befund andere Methoden, wie Chemotherapie oder Radiatio adjuvant oder neoadjuvant, notwendig werden.
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Remzi, M., Schwentner, C., Shariat, S., Grubmüller, B. (2016). Urothelkarzinom der Nieren und Harnleiter: Therapie. In: Michel, M., Thüroff, J., Janetschek, G., Wirth, M. (eds) Die Urologie. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-39940-4_70
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