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Die Urologie pp 327–346Cite as

Nierenparenchymtumoren

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Zusammenfassung

Dieses Kapitel beschreibt die Grundlagen der renoparenchymatösen Tumoren, wobei der Schwerpunkt naturgemäß auf dem Nierenzellkarzinom liegt. Auf eine Übersicht über epidemiologische Daten folgt eine Darstellung der Ätiologie und Risikofaktoren, wobei in dieser Hinsicht zwar einige etablierte Parameter definiert werden konnten, aber letztlich noch vieles im Dunkeln liegt. Die Übersicht über die verschiedenen histologischen Subtypen der renalen Neoplasien schließt auch eine eingehende Beschreibung hereditärer Krankheitsbilder ein. Abschließend wird noch auf die klinische Symptomatik und die Diagnostik eingegangen, wobei das Hauptaugenmerk in der Diagnostik renaler Raumforderungen auf der Bildgebung liegt.

Das folgende Kapitel beschreibt die Grundlagen der renoparenchymatösen Tumoren, wobei der Schwerpunkt naturgemäß auf dem Nierenzellkarzinom liegt. Auf eine Übersicht über epidemiologische Daten folgt eine Darstellung der Ätiologie und Risikofaktoren, wobei in dieser Hinsicht zwar einige etablierte Parameter definiert werden konnten, aber letztlich noch vieles im Dunkeln liegt. Die Übersicht über die verschiedenen histologischen Subtypen der renalen Neoplasien schließt auch eine eingehende Beschreibung hereditärer Krankheitsbilder ein. Abschließend wird noch auf die klinische Symptomatik und die Diagnostik eingegangen, wobei das Hauptaugenmerk in der Diagnostik renaler Raumforderungen auf der Bildgebung liegt.

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Literatur

  • Argani P, Lae M, Ballard ET, Amin M, Manivel C, Hutchinson B et al (2006) Translocation carcinomas of the kidney after chemotherapy in childhood. J Clin Oncol 24(10):1529–1534

    Article  CAS  PubMed  Google Scholar 

  • Ascenti G, Mazziotti S, Zimbaro G et al (2007) Complex cystic renal masses: characterization with contrast-enhanced US. Radiology 243:158–165

    Article  PubMed  Google Scholar 

  • Banumathy G, Cairns P (2010) Signaling pathways in renal cell carcinoma. Cancer Biol Ther 10:658–664

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bedke J, Buse S, Kurosch M, Haferkamp A, Jager D, Hohenfellner M (2007) Paraneoplastic syndrome in renal cell carcinoma. Urologe A 46(1):45–48

    Article  CAS  PubMed  Google Scholar 

  • Bellocco R, Pasquali E, Rota M, Bagnardi V, Tramacere I, Scotti L et al (2012) Alcohol drinking and risk of renal cell carcinoma: results of a meta-analysis. Ann Oncol 23(9):2235–2244

    Article  CAS  PubMed  Google Scholar 

  • Birt AR, Hogg GR, Dubé WJ (1977) Hereditary multiple fibrofolliculomas with trichodiscomas and acrochordons. Arch Dermatol 113(12):1674

    Article  CAS  PubMed  Google Scholar 

  • Bosniak MA (1997) The use of the Bosniak classification system for renal cysts and cystic tumors. J Urol 157(5):1852–1853

    Article  CAS  PubMed  Google Scholar 

  • Cindolo L, de la Taille A, Messina G et al (2003) A preoperative clinical prognostic model for non-metastatic renal cell carcinoma. BJU Int 92:901–905

    Article  CAS  PubMed  Google Scholar 

  • de Peralta-Venturina M, Moch H, Amin M, Tamboli P, Hailemariam S, Mihatsch M et al (2001) Sarcomatoid differentiation in renal cell carcinoma: a study of 101 cases. Am J Surg Pathol 25(3):275–284

    Article  PubMed  Google Scholar 

  • Delahunt B, Eble JN, McCredie M, Bethwaite PB, Stewart JH, Bilous AM (2001) Morphologic typing of papillary renal cell carcinoma: comparison of growth kinetics and patient survival in 66 cases. Hum Pathol 32(6):590

    Article  CAS  PubMed  Google Scholar 

  • Eble JN, Sauter G, Epstein JI (2004) Pathology and genetics of tumours of the urinary system and male genital organs, 7. Aufl, WHO classification of tumours. World Health Organisation, Lyon

    Google Scholar 

  • Ferlay J, Parkin DM, Steliarova-Foucher E (2010a) Estimates of cancer incidence and mortality in Europe in 2008. Eur J Cancer 46(4):765–781

    Article  CAS  PubMed  Google Scholar 

  • Ferlay J, Shin H, Bray F, Forman D, Mathers C, Parkin DM (2010b) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127(12):2893–2917

    Article  CAS  PubMed  Google Scholar 

  • Fuhrman SA, Lasky LC, Limas C (1982) Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol 6(7):655

    Article  CAS  PubMed  Google Scholar 

  • Hallscheidt P, Noeldge G, Schawo S et al (2007) Advances in the staging of renal cell carcinoma with high-resolution imaging. Rofo 179:1236–1242

    Article  CAS  PubMed  Google Scholar 

  • Hiddemann W, Bartram C (2010) Nierenzellkarzinom. In: Hiddemann W, Bartram C (Hrsg) Die Onkologie Teil 2: Solide Tumoren - Lymphome - Leukämien, 2. Aufl. Springer Medizin Verlag, Heidelberg, S 1088–1103

    Chapter  Google Scholar 

  • Hunt JD, van der Hel OL, McMillan GP, Boffetta P, Brennan P (2005) Renal cell carcinoma in relation to cigarette smoking: meta-analysis of 24 studies. Int J Cancer 114(1):101–108

    Article  CAS  PubMed  Google Scholar 

  • Hutterer GC, Patard JJ, Perrotte P et al (2007) Patients with renal cell carcinoma nodal metastases can be accurately identified: external validation of a new nomogram. Int J Cancer 121:2556–2561

    Article  CAS  PubMed  Google Scholar 

  • Hutterer GC, Patard JJ, Jeldres C et al (2008) Patients with distant metastases from renal cell carcinoma can be accurately identified: external validation of a new nomogram. BJU Int 101:39–43

    Article  PubMed  Google Scholar 

  • Inoki K, Li Y, Zhu T, Wu J, Guan K (2002) TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol 4(9):648–657

    Article  CAS  PubMed  Google Scholar 

  • Isaacs JS, Jung YJ, Mole DR, Lee S, Torres-Cabala C, Chung YL et al (2005) HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability. Cancer Cell 8(2):143–153

    Article  CAS  PubMed  Google Scholar 

  • Israel G, Bosniak A (2005) How I do it: evaluating renal masses. Radiology 236:441–450

    Article  PubMed  Google Scholar 

  • Kalinka A, Gerlach A, Arlart IP, Gunes N, Hauser TK, Wurstlin S, Bosse A (2006) Characterization and staging of renal tumors: significance of MRI diagnostics. Rofo 178:298–305

    Article  CAS  PubMed  Google Scholar 

  • Karakiewicz PI, Suardi N, Capitanio U et al (2009) A preoperative prognostic model for patients treated with nephrectomy for renal cell carcinoma. Eur Urol 55:287–295

    Article  PubMed  Google Scholar 

  • Karnofsky DA, Burchenal JH (1949) The clinical evaluation of chemotherapeutic agents in cancer. In: MacLeod CM (Hrsg) Evaluation of chemotherapeutic agents. Columbia University Press, New York, S 191–205

    Google Scholar 

  • Keaney JJ, Hannon CM, Murray PT (2013) Contrast-induced acute kidney injury: how much contrast is safe? Nephrol Dial Transplant 28:1376–1383

    Article  PubMed  Google Scholar 

  • Klatte T (2012) The contemporary role of renal tumor biopsy. Eur Urol 62(3):505–506

    Article  PubMed  Google Scholar 

  • Kuroda N, Toi M, Hiroi M, Shuin T, Enzan H (2003) Review of renal oncocytoma with focus on clinical and pathobiological aspects. Histol Histopathol 18(3):935–942

    CAS  PubMed  Google Scholar 

  • Kutikov A, Egleston BL, Wong YN, Uzzo RG (2010) Evaluating overall survival and competing risks of death in patients with localized renal cell carcinoma using a comprehensive nomogram. J Clin Oncol 28:311–317

    Article  PubMed  Google Scholar 

  • Latif F, Tory K, Gnarra J, Yao M, Duh F, Orcutt ML et al (1993) Identification of the von Hippel-Lindau disease tumor suppressor gene. Science 260(5112):1317

    Article  CAS  PubMed  Google Scholar 

  • Linehan WM, Srinivasan R, Schmidt LS (2010) The genetic basis of kidney cancer: a metabolic disease. Nat Rev Urol 7:277–285

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lipworth L, Tarone RE, McLaughlin JK (2006) The epidemiology of renal cell carcinoma. J Urol 176(6):2353–2358

    Article  PubMed  Google Scholar 

  • Lipworth L, Tarone RE, McLaughlin JK (2011) Renal cell cancer among African Americans: an epidemiologic review. BMC Cancer. 11:133

    Article  PubMed  PubMed Central  Google Scholar 

  • Ljungberg B, Campbell SC, Cho HY, Jacqmin D, Lee JE, Weikert S et al (2011) The epidemiology of renal cell carcinoma. Eur Urol 60(4):615–621

    Article  PubMed  Google Scholar 

  • Ljungberg B, Bensalah K, Bex A et al (2015) EAU guidelines on renal cell carcinoma, update 2015. http://uroweb.org/guideline/renal-cell-carcinoma/. Zugegriffen im März 2015.

  • Maher ER, Neumann HP, Richard S (2011) von Hippel–Lindau disease: a clinical and scientific review. Eur J Hum Genet 19(6):617–623

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • McDonald JS, McDonald RJ, Comin J et al (2013) Frequency of acute kidney injury following intravenous contrast medium administration: a systematic review and meta-analysis. Radiology 267:119–128

    Article  PubMed  Google Scholar 

  • Menko FH, van Steensel MA, Giraud S, Friis-Hansen L, Richard S, Ungari S et al (2009) Birt-Hogg-Dube syndrome: diagnosis and management. Lancet Oncol 10(12):1199–1206

    Article  CAS  PubMed  Google Scholar 

  • Moch H (2013) An overview of renal cell cancer: pathology and genetics. Semin Cancer Biol 23:3–9

    Article  CAS  PubMed  Google Scholar 

  • Moch H, Artibani W, Delahunt B, Ficarra V, Knuechel R, Montorsi F et al (2009) Reassessing the current UICC/AJCC TNM staging for renal cell carcinoma. Eur Urol 56(4):636–643

    Article  PubMed  Google Scholar 

  • Navai N, Wood CG (2012) Environmental and modifiable risk factors in renal cell carcinoma. Urol Oncol 30(2):220–224

    Article  PubMed  Google Scholar 

  • Nguyen CT, Campbell SC (2006) Staging of renal cell carcinoma: past, present, and future. Clin Genitourin Cancer 5(3):190–197

    Article  PubMed  Google Scholar 

  • Oken MM, Creech RH, Tormey DC, Horton J, Davis TE, McFadden ET et al (1982) Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol 5(6):649–656

    Article  CAS  PubMed  Google Scholar 

  • Pallwein L, Mitterberger M, Aigner F et al (2007) Small renal masses: the value of contrast-enhanced colour Doppler imaging. BJU Int 99:579–585

    Article  PubMed  Google Scholar 

  • Patard J, Leray E, Rodriguez A, Rioux-Leclercq N, Guillé F, Lobel B (2003) Correlation between symptom graduation, tumor characteristics and survival in renal cell carcinoma. Eur Urol 44(2):226–232

    Article  PubMed  Google Scholar 

  • Patard J, Leray E, Rioux-Leclercq N, Cindolo L, Ficarra V, Zisman A et al (2005) Prognostic value of histologic subtypes in renal cell carcinoma: a multicenter experience. J Clin Oncol 23(12):2763–2771

    Article  PubMed  Google Scholar 

  • Pichler M, Hutterer GC, Chromecki TF et al (2011) External validation of the Leibovich prognosis score for nonmetastatic clear cell renal cell carcinoma at a single European center applying routine pathology. J Urol 186:1773–1777

    Article  PubMed  Google Scholar 

  • Protzel C, Maruschke M, Hakenberg OW (2012) Epidemiology, aetiology, and pathogenesis of renal cell carcinoma. Eur Urol Suppl 11(3):52–59

    Article  CAS  Google Scholar 

  • Raj GV, Thompson RH, Leibovich BC et al (2008) Preoperative nomogram predicting 12-year probability of metastatic renal cancer. J Urol 179:2146–2151

    Article  PubMed  PubMed Central  Google Scholar 

  • Remzi M, Marberger M (2009) Renal tumor biopsies for evaluation of small renal tumors: why, in whom, and how? Eur Urol 55(2):359–367

    Article  PubMed  Google Scholar 

  • Rioux-Leclercq N, Karakiewicz PI, Trinh Q, Ficarra V, Cindolo L, de la Taille A et al (2007) Prognostic ability of simplified nuclear grading of renal cell carcinoma. Cancer 109(5):868–874

    Article  PubMed  Google Scholar 

  • Ross H, Argani P (2010) Xp11 translocation renal cell carcinoma. Pathology 42(4):369–373

    Article  CAS  PubMed  Google Scholar 

  • Roth JS, Rabinowitz AD, Benson M, Grossman ME (1993) Bilateral renal cell carcinoma in the Birt-Hogg-Dube syndrome. J Am Acad Dermatol 29(6):1055–1056

    Article  CAS  PubMed  Google Scholar 

  • Schaefer-Prokop CM (1998) Bildgebende Diagnostik des Nierenzellkarzinoms. Onkologe 4:221–228

    Article  Google Scholar 

  • Schips L, Lipsky K, Zigeuner R et al (2003) Impact of tumor-associated symptoms on the prognosis of patients with renal cell carcinoma: a single-center experience of 683 patients. Urology 62:1024–1028

    Article  PubMed  Google Scholar 

  • Sobin L, Gospodarowicz M, Wittekind C (2009) AJCC staging manual, 7. Aufl. Springer, Philadelphia

    Google Scholar 

  • Srigley JR, Delahunt B (2009) Uncommon and recently described renal carcinomas. Mod Pathol 22(Suppl 2):S2–S23

    Article  PubMed  Google Scholar 

  • Studer UE, Scherz S, Scheidegger J et al (1990) Enlargement of regional lymph nodes in renal cell carcinoma is often not due to metastases. J Urol 144:243–245

    CAS  PubMed  Google Scholar 

  • Tran LN, Brown MS, Goldin JG et al (2004) Comparison of treatment response classifications between unidimensional, bidimensional, and volumetric measurements of metastatic lung lesions on chest computed tomography. Acad Radiol 11:1355–1360

    Article  PubMed  Google Scholar 

  • Truong LD, Krishnan B, Cao JTH, Barrios R, Suki WN (1995) Renal neoplasm in acquired cystic kidney disease. Am J Kidney Dis 26(1):1–12

    Article  CAS  PubMed  Google Scholar 

  • Verine J, Pluvinage A, Bousquet G, Lehmann-Che J, de Bazelaire C, Soufir N et al (2010) Hereditary renal cancer syndromes: an update of a systematic review. Eur Urol 58(5):701–710

    Article  PubMed  Google Scholar 

  • Yaycioglu O, Roberts WW, Chan T et al (2001) Prognostic assessment of nonmetastatic renal cell carcinoma: a clinically based model. Urology 58:141–145

    Article  CAS  PubMed  Google Scholar 

  • Zhang J, Lefkowitz RA, Ishill NM et al (2007) Solid renal cortical tumors: differentiation with CT. Radiology 244:494–504

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Univ.-Klinik für Urologie, Medizinische Universität Graz, Auenbruggerplatz 5/6, 8036, Graz, Österreich

    Richard Zigeuner & S. V. Golbeck

  2. Abteilung für Onkologie, Medizinische Universität Graz, Graz, Österreich

    M. Pichler

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  1. Richard Zigeuner
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  2. S. V. Golbeck
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  3. M. Pichler
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Correspondence to Richard Zigeuner .

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Editors and Affiliations

  1. Universitätsklinikum Mannheim, Klinik für Urologie, Mannheim, Baden-Württemberg, Germany

    Maurice Stephan Michel

  2. Klinik für Urologie, Universitätsklinik Mannheim, Mainz, Germany

    Joachim W. Thüroff

  3. Abt. für Urologie, Universitätsklinikum Salzburg, Salzburg, Austria

    Günther Janetschek

  4. Klinik und Poliklinik für Urologie, Univer Tech Univ Dresden, Dresden, Germany

    Manfred Wirth

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Zigeuner, R., Golbeck, S.V., Pichler, M. (2016). Nierenparenchymtumoren. In: Michel, M., Thüroff, J., Janetschek, G., Wirth, M. (eds) Die Urologie. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-39940-4_63

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  • DOI: https://doi.org/10.1007/978-3-642-39940-4_63

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