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Late Effects in Survivors After Hematopoietic Cell Transplantation in Childhood

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Hematopoietic Cell Transplantation in Children with Cancer

Part of the book series: Pediatric Oncology ((PEDIATRICO))

Abstract

A reduction in the mortality secondary to relapse, infections, graft versus host disease, and other acute transplant related complications is leading to improved survival rates and thus an ever-increasing population of hematopoietic cell transplant (HCT) survivors. For survivors of HCT during childhood, late effects can have a significant adverse impact on their overall functional outcomes and quality of life. This chapter will highlight what we are learning about long-term risks that may either be preventable with appropriate monitoring and screening or manageable with appropriate interventions. It is increasingly important that our long-term survivors be educated regarding their potential long-term risks and that they continue to receive periodic evaluations by providers who are knowledgeable regarding the unique issues that HCT survivors may face.

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References

  • Abboud I, Porcher R, Robin M, de Latour RP, Glotz D, Socie G, Peraldi MN (2009) Chronic kidney dysfunction in patients alive without relapse 2 years after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 15(10):1251–1257

    PubMed  CAS  Google Scholar 

  • Aceves SS, Bastian JF, Newbury RO, Dohil R (2007) Oral viscous budesonide: a potential new therapy for eosinophilic esophagitis in children. Am J Gastroenterol 102(10):2271–2279

    PubMed  CAS  Google Scholar 

  • Afify Z, Shaw PJ, Clavano-Harding A, Cowell CT (2000) Growth and endocrine function in children with acute myeloid leukaemia after bone marrow transplantation using busulfan/cyclophosphamide. Bone Marrow Transplant 25(10):1087–1092. doi:10.1038/sj.bmt.1702384

    PubMed  CAS  Google Scholar 

  • Agarwala S, Jain D, Joshi VR, Sule A (2005) Efficacy of alendronate, a bisphosphonate, in the treatment of AVN of the hip. A prospective open-label study [erratum appears in Rheumatology (Oxford). 2005 Apr;44(4):569]. Rheumatology 44(3):352–359

    PubMed  CAS  Google Scholar 

  • Akar H, Keven K, Celebi H, Orhan D, Nergizoglu G, Erbay B, Tulunay O, Ozcan M, Erturk S (2002) Nephrotic syndrome after allogeneic peripheral blood stem cell transplantation. J Nephrol 15(1):79–82

    PubMed  Google Scholar 

  • Akpek G, Valladares JL, Lee L, Margolis J, Vogelsang GB (2001) Pancreatic insufficiency in patients with chronic graft-versus-host disease. Bone Marrow Transplant 27(2):163–166

    PubMed  CAS  Google Scholar 

  • Akpek G, Chinratanalab W, Lee LA, Torbenson M, Hallick JP, Anders V, Vogelsang GB (2003) Gastrointestinal involvement in chronic graft-versus-host disease: a clinicopathologic study. Biol Blood Marrow Transplant 9(1):46–51

    PubMed  Google Scholar 

  • Ali S, Pimentel JD, Munoz J, Shah V, McKinnon R, Divine G, Janakiraman N (2012) Iron overload in allogeneic hematopoietic stem cell transplant recipients. Arch Pathol Lab Med 136(5):532–538

    PubMed  CAS  Google Scholar 

  • Altes A, Remacha AF, Sureda A, Martino R, Briones J, Canals C, Brunet S, Sierra J, Gimferrer E (2002) Iron overload might increase transplant-related mortality in haematopoietic stem cell transplantation. Bone Marrow Transplant 29(12):987–989

    PubMed  CAS  Google Scholar 

  • Anserini P, Chiodi S, Spinelli S, Costa M, Conte N, Copello F, Bacigalupo A (2002) Semen analysis following allogeneic bone marrow transplantation. Additional data for evidence-based counselling. Bone Marrow Transplant 30(7):447–451. doi:10.1038/sj.bmt.1703651

    PubMed  CAS  Google Scholar 

  • Aristei C, Alessandro M, Santucci A, Aversa F, Tabillo A, Carotti A, Latini RA, Cagini C, Latini P (2002) Cataracts in patients receiving stem cell transplantation after conditioning with total body irradiation. Bone Marrow Transplant 29(6):503–507

    PubMed  CAS  Google Scholar 

  • Arlet J (1992) Nontraumatic avascular necrosis of the femoral head. Past, present, and future (Review). Clin Orthop Relat Res 277:12–21

    PubMed  Google Scholar 

  • Armand P, Kim HT, Rhodes J, Sainvil MM, Cutler C, Ho VT, Koreth J, Alyea EP, Hearsey D, Neufeld EJ, Fleming MD, Steen H, Anderson D, Kwong RY, Soiffer RJ, Antin JH (2011) Iron overload in patients with acute leukemia or MDS undergoing myeloablative stem cell transplantation. Biol Blood Marrow Transplant 17(6):852–860

    PubMed  CAS  Google Scholar 

  • Armand P, Sainvil MM, Kim HT, Rhodes J, Cutler C, Ho VT, Koreth J, Alyea EP, Neufeld EJ, Kwong RY, Soiffer RJ, Antin JH (2012) Does iron overload really matter in stem cell transplantation? Am J Hematol 87(6):569–572

    PubMed  CAS  Google Scholar 

  • Armenian SH, Sun CL, Kawashima T, Arora M, Leisenring W, Sklar CA, Baker KS, Francisco L, Teh JB, Mills G, Wong FL, Rosenthal J, Diller LR, Hudson MM, Oeffinger KC, Forman SJ, Robison LL, Bhatia S (2011) Long-term health-related outcomes in survivors of childhood cancer treated with HSCT versus conventional therapy: a report from the Bone Marrow Transplant Survivor Study (BMTSS) and Childhood Cancer Survivor Study (CCSS). Blood 118(5):1413–1420. doi:10.1182/blood-2011-01-331835, blood-2011-01-331835 [pii]

    PubMed  CAS  Google Scholar 

  • Atkinson SA, Halton JM, Bradley C, Wu B, Barr RD (1998) Bone and mineral abnormalities in childhood acute lymphoblastic leukemia: influence of disease, drugs and nutrition. Int J Cancer Suppl 11:35–39

    PubMed  CAS  Google Scholar 

  • Atree SV, Crilley PA, Conroy JF, Micaily B, Brodsky JT (1995) Cancer of the esophagus following allogeneic bone marrow transplantation for acute leukemia. Am J Clin Oncol 18(4):343–347

    PubMed  CAS  Google Scholar 

  • Au WY, Ma ES, Lee TL, Ha SY, Fung AT, Lie AK, Kwong YL (2007) Successful treatment of thrombotic microangiopathy after haematopoietic stem cell transplantation with rituximab. Br J Haematol 137(5):475–478

    PubMed  CAS  Google Scholar 

  • Bae SJ, Kang C, Sung KW, Chueh HW, Son MH, Lee SH, Yoo KH, Koo HH (2012) Iron Overload during Follow-up after Tandem High-Dose Chemotherapy and Autologous Stem Cell Transplantation in Patients with High-Risk Neuroblastoma. J Korean Med Sci 27(4):363–369

    PubMed  CAS  Google Scholar 

  • Baek KH, Lee WY, Oh KW, Kim HS, Han JH, Kang MI, Cha BY, Lee KW, Son HY, Kang SK, Kim CC (2004) Changes in the serum growth factors and osteoprotegerin after bone marrow transplantation: impact on bone and mineral metabolism. J Clin Endocrinol Metab 89(3):1246–1254

    PubMed  CAS  Google Scholar 

  • Bagesund M, Richter S, Agren B, Ringden O, Dahllof G (2000a) Scintigraphic study of the major salivary glands in pediatric bone marrow transplant recipients. Bone Marrow Transplant 26(7):775–779

    PubMed  CAS  Google Scholar 

  • Bagesund M, Winiarski J, Dahllof G (2000b) Subjective xerostomia in long-term surviving children and adolescents after pediatric bone marrow transplantation. Transplantation 69(5):822–826

    PubMed  CAS  Google Scholar 

  • Bai HX, Ma MH, Orabi AI, Park A, Latif SU, Bhandari V, Husain SZ (2011) Novel characterization of drug-associated pancreatitis in children. J Pediatr Gastroenterol Nutr 53(4):423–428

    PubMed  CAS  Google Scholar 

  • Bailey HK, Kappy MS, Giller RH, Gralla J (2008) Time-course and risk factors of hypothyroidism following allogeneic hematopoietic stem cell transplantation (HSCT) in children conditioned with fractionated total body irradiation. Pediatr Blood Cancer 51(3):405–409. doi:10.1002/pbc.21634

    PubMed  Google Scholar 

  • Baim S, Leonard MB, Bianchi ML, Hans DB, Kalkwarf HJ, Langman CB, Rauch F (2008) Official Positions of the International Society for Clinical Densitometry and executive summary of the 2007 ISCD Pediatric Position Development Conference. J Clin Densitom 11(1):6–21. doi:10.1016/j.jocd.2007.12.002, S1094-6950(07)00250-8 [pii]

    PubMed  Google Scholar 

  • Baker KS, DeFor TE, Burns LJ, Ramsay NK, Neglia JP, Robison LL (2003) New malignancies after blood or marrow stem-cell transplantation in children and adults: incidence and risk factors. J Clin Oncol 21(7):1352–1358

    PubMed  Google Scholar 

  • Baker KS, Gurney JG, Ness KK, Bhatia R, Forman SJ, Francisco L, McGlave PB, Robison LL, Snyder DS, Weisdorf DJ, Bhatia S (2004) Late effects in survivors of chronic myeloid leukemia treated with hematopoietic cell transplantation: results from the Bone Marrow Transplant Survivor Study. Blood 104(6):1898–1906. doi:10.1182/blood-2004-03-1010, 2004-03-1010 [pii]

    PubMed  CAS  Google Scholar 

  • Baker KS, Ness KK, Steinberger J, Carter A, Francisco L, Burns LJ, Sklar C, Forman S, Weisdorf D, Gurney JG, Bhatia S (2007) Diabetes, hypertension, and cardiovascular events in survivors of hematopoietic cell transplantation: a report from the bone marrow transplantation survivor study. Blood 109(4):1765–1772. doi:10.1182/blood-2006-05-022335, blood-2006-05-022335 [pii]

    PubMed  CAS  Google Scholar 

  • Baker KS, Steffen L, Zhou X, Kelly A, Lee JM, Petryk A, Sinaiko AR, Dengel DR, Mulrooney DA, Steinberger J (2009) Total body irradiation (TBI) increases cardio-metabolic risk and induces carotid vascular stiffness in survivors after hematopoietic cell transplant (HCT) for childhood hematologic malignancies. Blood 114(22):1291

    Google Scholar 

  • Balasubramaniam R, Alawi F, DeRossi S (2009) Superficial mucoceles in chronic graft-versus-host disease: a case report and review of the literature. Gen Dent 57(1):82–88

    PubMed  Google Scholar 

  • Banfi A, Podesta M, Fazzuoli L, Sertoli MR, Venturini M, Santini G, Cancedda R, Quarto R (2001) High-dose chemotherapy shows a dose-dependent toxicity to bone marrow osteoprogenitors: a mechanism for post-bone marrow transplantation osteopenia. Cancer 92(9):2419–2428, 10.1002/1097-0142(20011101)92:9 < 2419::AID-CNCR1591 > 3.0.CO;2-K [pii]

    PubMed  CAS  Google Scholar 

  • Barrera M, Atenafu E (2008) Cognitive, educational, psychosocial adjustment and quality of life of children who survive hematopoietic SCT and their siblings. Bone Marrow Transplant 42(1):15–21. doi:10.1038/bmt.2008.84, bmt200884 [pii]

    PubMed  CAS  Google Scholar 

  • Barrera M, Atenafu E, Andrews GS, Saunders F (2008) Factors related to changes in cognitive, educational and visual motor integration in children who undergo hematopoietic stem cell transplant. J Pediatr Psychol 33(5):536–546. doi:10.1093/jpepsy/jsm080, jsm080 [pii]

    PubMed  Google Scholar 

  • Batts ED, Lazarus HM (2007) Diagnosis and treatment of transplantation-associated thrombotic microangiopathy: real progress or are we still waiting? Bone Marrow Transplant 40(8):709–719

    PubMed  CAS  Google Scholar 

  • Benyunes MC, Sullivan KM, Deeg HJ, Mori M, Meyer W, Fisher L, Bensinger R, Jack MK, Hicks J, Witherspoon R, Buckner CD, Hansen JA, Appelbaum FR, Storb R (1995) Cataracts after bone marrow transplantation: long-term follow-up of adults treated with fractionated total body irradiation. Int J Radiat Oncol Biol Phys 32(3):661–670

    PubMed  CAS  Google Scholar 

  • Berg U, Bolme P (1989) Renal function in children following bone marrow transplantation. Transplant Proc 21(1 Pt 3):3092–3094

    PubMed  CAS  Google Scholar 

  • Berger C, Le-Gallo B, Donadieu J, Richard O, Devergie A, Galambrun C, Bordigoni P, Vilmer E, Plouvier E, Perel Y, Michel G, Stephan JL (2005) Late thyroid toxicity in 153 long-term survivors of allogeneic bone marrow transplantation for acute lymphoblastic leukaemia. Bone Marrow Transplant 35(10):991–995. doi:10.1038/sj.bmt.1704945, 1704945 [pii]

    PubMed  CAS  Google Scholar 

  • Bhatia S, Robison LL, Francisco L, Carter A, Liu Y, Grant M, Baker KS, Fung H, Gurney JG, McGlave PB, Nademanee A, Ramsay NK, Stein A, Weisdorf DJ, Forman SJ (2005) Late mortality in survivors of autologous hematopoietic-cell transplantation: report from the Bone Marrow Transplant Survivor Study. Blood 105(11):4215–4222. doi:10.1182/blood-2005-01-0035, 2005-01-0035 [pii]

    PubMed  CAS  Google Scholar 

  • Bhatia S, Francisco L, Carter A, Sun CL, Baker KS, Gurney JG, McGlave PB, Nademanee A, O'Donnell M, Ramsay NK, Robison LL, Snyder D, Stein A, Forman SJ, Weisdorf DJ (2007) Late mortality after allogeneic hematopoietic cell transplantation and functional status of long-term survivors: report from the Bone Marrow Transplant Survivor Study. Blood 110(10):3784–3792. doi:10.1182/blood-2007-03-082933, blood-2007-03-082933 [pii]

    PubMed  CAS  Google Scholar 

  • Bishop N, Braillon P, Burnham J, Cimaz R, Davies J, Fewtrell M, Hogler W, Kennedy K, Makitie O, Mughal Z, Shaw N, Vogiatzi M, Ward K, Bianchi ML (2008) Dual-energy X-ray absorptiometry assessment in children and adolescents with diseases that may affect the skeleton: the 2007 ISCD Pediatric Official Positions. J Clin Densitom 11(1):29–42. doi:10.1016/j.jocd.2007.12.004, S1094-6950(07)00252-1 [pii]

    PubMed  Google Scholar 

  • Bobak D, Arfons LM, Creger RJ, Lazarus HM (2008) Clostridium difficile-associated disease in human stem cell transplant recipients: coming epidemic or false alarm? Bone Marrow Transplant 42(11): 705–713

    PubMed  CAS  Google Scholar 

  • Borgmann A, Zinn C, Hartmann R, Herold R, Kaatsch P, Escherich G, Moricke A, Henze G, von Stackelberg A (2008) Secondary malignant neoplasms after intensive treatment of relapsed acute lymphoblastic leukaemia in childhood. Eur J Cancer 44(2):257–268

    PubMed  Google Scholar 

  • Borgstrom B, Bolme P (1994) Thyroid function in children after allogeneic bone marrow transplantation. Bone Marrow Transplant 13(1):59–64

    PubMed  CAS  Google Scholar 

  • Boulad F, Bromley M, Black P, Heller G, Sarafoglou K, Gillio A, Papadopoulos E, Sklar C (1995) Thyroid dysfunction following bone marrow transplantation using hyperfractionated radiation. Bone Marrow Transplant 15(1):71–76

    PubMed  CAS  Google Scholar 

  • Bozzola M, Giorgiani G, Locatelli F, Cisternino M, Gambarana D, Zecca M, Torcetta F, Severi F (1993) Growth in children after bone marrow transplantation. Horm Res 39(3–4):122–126

    PubMed  CAS  Google Scholar 

  • Brand HS, Bots CP, Raber-Durlacher JE (2009) Xerostomia and chronic oral complications among patients treated with haematopoietic stem cell transplantation. Br Dent J 207(9):E17, discussion 428–429

    PubMed  CAS  Google Scholar 

  • Brauner R, Fontoura M, Zucker JM, Devergie A, Souberbielle JC, Prevot-Saucet C, Michon J, Gluckman E, Griscelli C, Fischer A et al (1993) Growth and growth hormone secretion after bone marrow transplantation. Arch Dis Childhood 68(4):458–463

    CAS  Google Scholar 

  • Brauner R, Adan L, Souberbielle JC, Esperou H, Michon J, Devergie A, Gluckman E, Zucker JM (1997) Contribution of growth hormone deficiency to the growth failure that follows bone marrow transplantation. J Pediatr 130(5):785–792, S0022-3476(97)80022-4 [pii]

    PubMed  CAS  Google Scholar 

  • Bray LC, Carey PJ, Proctor SJ, Evans RG, Hamilton PJ (1991) Ocular complications of bone marrow transplantation. Br J Ophthalmol 75(10):611–614

    PubMed  CAS  Google Scholar 

  • Brittenham GM, Badman DG (2003) Noninvasive measurement of iron: report of an NIDDK workshop. Blood 101(1):15–19

    PubMed  CAS  Google Scholar 

  • Brukamp K, Doyle AM, Bloom RD, Bunin N, Tomaszewski JE, Cizman B (2006) Nephrotic syndrome after hematopoietic cell transplantation: do glomerular lesions represent renal graft-versus-host disease? Clin J Am Soc Nephrol 1(4):685–694

    PubMed  Google Scholar 

  • Busca A, Uderzo C (2000) BMT: Bone Marrow Transplant Associated Thrombotic Microangiopathy. Hematology 5(1):53–67

    PubMed  Google Scholar 

  • Bushhouse S, Ramsay NK, Pescovitz OH, Kim T, Robison LL (1989) Growth in children following irradiation for bone marrow transplantation. Am J Pediat Hematol/Oncol 11(2):134–140

    CAS  Google Scholar 

  • Butcher JA, Hariharan S, Adams MB, Johnson CP, Roza AM, Cohen EP (1999) Renal transplantation for end-stage renal disease following bone marrow transplantation: a report of six cases, with and without immunosuppression. Clin Transplant 13(4):330–335

    PubMed  CAS  Google Scholar 

  • Calissendorff BM, Bolme P (1993) Cataract development and outcome of surgery in bone marrow transplanted children. Br J Ophthalmol 77(1):36–38

    PubMed  CAS  Google Scholar 

  • Campbell J, Moravec C (2008) Long term complications of hematopoietic stem cell transplantation. Stem cell transplantation clinical textbook. Oncology Nursing Press, Pittsburgh

    Google Scholar 

  • Carella AM, D'Arena G, Greco MM, Nobile M, Cascavilla N (2008) Rituximab for allo-SCT-associated thrombotic thrombocytopenic purpura. Bone Marrow Transplant 41(12):1063–1065

    PubMed  CAS  Google Scholar 

  • Carlson K, Simonsson B, Ljunghall S (1994) Acute effects of high-dose chemotherapy followed by bone marrow transplantation on serum markers of bone metabolism. Calcif Tissue Int 55(6):408–411

    PubMed  CAS  Google Scholar 

  • Carneiro AA, Fernandes JP, de Araujo DB, Elias J Jr, Martinelli AL, Covas DT, Zago MA, Angulo IL, St Pierre TG, Baffa O (2005) Liver iron concentration evaluated by two magnetic methods: magnetic resonance imaging and magnetic susceptometry. Magn Reson Med 54(1):122–128

    PubMed  CAS  Google Scholar 

  • Carpenter PA, Hoffmeister P, Chesnut CH 3rd, Storer B, Charuhas PM, Woolfrey AE, Sanders JE (2007) Bisphosphonate therapy for reduced bone mineral density in children with chronic graft-versus-host disease. Biol Blood Marrow Transplant 13(6):683–690. doi:10.1016/j.bbmt.2007.02.001, S1083-8791(07)00146-2 [pii]

    PubMed  CAS  Google Scholar 

  • Carter A, Robison LL, Francisco L, Smith D, Grant M, Baker KS, Gurney JG, McGlave PB, Weisdorf DJ, Forman SJ, Bhatia S (2006) Prevalence of conception and pregnancy outcomes after hematopoietic cell transplantation: report from the Bone Marrow Transplant Survivor Study. Bone Marrow Transplant 37(11):1023–1029. doi:10.1038/sj.bmt.1705364, 1705364 [pii]

    PubMed  CAS  Google Scholar 

  • Castaneda S, Carmona L, Carvajal I, Arranz R, Diaz A, Garcia-Vadillo A (1997) Reduction of bone mass in women after bone marrow transplantation. Calcif Tissue Int 60(4):343–347

    PubMed  CAS  Google Scholar 

  • Castro FP Jr, Barrack RL (2000) Core decompression and conservative treatment for avascular necrosis of the femoral head: a meta-analysis. Am J Orthop (Chatham, NJ) 29(3):187–194

    Google Scholar 

  • Chae YS, Kim JG, Moon JH, Kim SN, Lee SJ, Kim YJ, Sohn SK (2009) Pilot study on the use of zoledronic acid to prevent bone loss in allo-SCT recipients. Bone Marrow Transplant 44(1):35–41. doi:10.1038/bmt.2008.414, bmt2008414 [pii]

    PubMed  CAS  Google Scholar 

  • Chan GS, Lam MF, Au WY, Tse KC, Chan TM, Lai KN, Chan KW (2004) IgA nephropathy complicating graft-versus-host disease, another nephropathy causing nephrotic syndrome after bone marrow transplantation. Histopathology 45(6):648–651

    PubMed  Google Scholar 

  • Changsirikulchai S, Myerson D, Guthrie KA, McDonald GB, Alpers CE, Hingorani SR (2009) Renal thrombotic microangiopathy after hematopoietic cell transplant: role of GVHD in pathogenesis. Clin J Am Soc Nephrol 4(2):345–353

    PubMed  Google Scholar 

  • Cherqui D, Rahmouni A, Charlotte F, Boulahdour H, Metreau JM, Meignan M, Fagniez PL, Zafrani ES, Mathieu D, Dhumeaux D (1995) Management of focal nodular hyperplasia and hepatocellular adenoma in young women: a series of 41 patients with clinical, radiological, and pathological correlations. Hepatology 22(6):1674–1681

    PubMed  CAS  Google Scholar 

  • Choi CM, Schmaier AH, Snell MR, Lazarus HM (2009) Thrombotic microangiopathy in haematopoietic stem cell transplantation: diagnosis and treatment. Drugs 69(2):183–198

    PubMed  CAS  Google Scholar 

  • Chotsampancharoen T, Gan K, Kasow KA, Barfield RC, Hale GA, Leung W (2009) Iron overload in survivors of childhood leukemia after allogeneic hematopoietic stem cell transplantation. Pediatr Transplant 13(3):348–352

    PubMed  CAS  Google Scholar 

  • Clark WF (2012) Plasma exchange for renal disease: Evidence and use 2011. J Clin Apher 27(3):112–116. doi:10.1002/jca.21221

    PubMed  CAS  Google Scholar 

  • Clarke SA, Eiser C, Skinner R (2008) Health-related quality of life in survivors of BMT for paediatric malignancy: a systematic review of the literature. Bone Marrow Transplant 42(2):73–82. doi:10.1038/bmt.2008.156, bmt2008156 [pii]

    PubMed  Google Scholar 

  • Clement-De Boers A, Oostdijk W, Van Weel-Sipman MH, Van den Broeck J, Wit JM, Vossen JM (1996) Final height and hormonal function after bone marrow transplantation in children. J Pediatr 129(4):544–550

    PubMed  CAS  Google Scholar 

  • Cohen A, Rovelli A, Van-Lint MT, Uderzo C, Morchio A, Pezzini C, Masera G, Bacigalupo A, Romano C (1996) Final height of patients who underwent bone marrow transplantation during childhood. Arch Dis Childhood 74(5):437–440

    CAS  Google Scholar 

  • Cohen EP, Piering WF, Kabler-Babbitt C, Moulder JE (1998) End-stage renal disease (ESRD)after bone marrow transplantation: poor survival compared to other causes of ESRD. Nephron 79(4):408–412

    PubMed  CAS  Google Scholar 

  • Cohen A, Rovelli A, Bakker B, Uderzo C, van Lint MT, Esperou H, Gaiero A, Leiper AD, Dopfer R, Cahn JY, Merlo F, Kolb HJ, Socie G (1999) Final height of patients who underwent bone marrow transplantation for hematological disorders during childhood: a study by the Working Party for Late Effects-EBMT. Blood 93(12):4109–4115

    PubMed  CAS  Google Scholar 

  • Cohen A, Rovelli A, van Lint MT, Merlo F, Gaiero A, Mulas R, Balduzzi A, Corti P, Uderzo C, Bacigalupo A (2001) Secondary thyroid carcinoma after allogeneic bone marrow transplantation during childhood. Bone Marrow Transplant 28(12):1125–1128. doi:10.1038/sj.bmt.1703290

    PubMed  CAS  Google Scholar 

  • Cohen A, Rovelli A, Merlo DF, van Lint MT, Lanino E, Bresters D, Ceppi M, Bocchini V, Tichelli A, Socie G (2007) Risk for secondary thyroid carcinoma after hematopoietic stem-cell transplantation: an EBMT Late Effects Working Party Study. J Clin Oncol 25(17):2449–2454. doi:10.1200/JCO.2006.08.9276, 25/17/2449 [pii]

    PubMed  Google Scholar 

  • Couriel D, Carpenter PA, Cutler C, Bolaños-Meade J, Treister NS, Gea-Banacloche J, Shaughnessy P, Hymes S, Kim S, Wayne AS, Chien JW, Neumann J, Mitchell S, Syrjala K, Moravec CK, Abramovitz L, Liebermann J, Berger A, Gerber L, Schubert M, Filipovich AH, Weisdorf D, Schubert MM, Shulman H, Schultz K, Mittelman B, Pavletic S, Vogelsang GB, Martin PJ, Lee SJ, Flowers MED (2006) Ancillary therapy and supportive care of chronic graft-versus-host disease: National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: V. Ancillary Therapy and Supportive Care Working Group report. Biol Blood Marrow Transplant 12(4):375–396

    PubMed  Google Scholar 

  • Cruz DN, Perazella MA, Mahnensmith RL (1997) Bone marrow transplant nephropathy: a case report and review of the literature. J Am Soc Nephrol 8(1):166–173

    PubMed  CAS  Google Scholar 

  • Cummings SR, Bates D, Black DM (2002) Clinical use of bone densitometry: scientific review. JAMA 288(15):1889–1897, jsr20013 [pii]

    PubMed  Google Scholar 

  • Curtis RE, Metayer C, Rizzo JD, Socie G, Sobocinski KA, Flowers ME, Travis WD, Travis LB, Horowitz MM, Deeg HJ (2005) Impact of chronic GVHD therapy on the development of squamous-cell cancers after hematopoietic stem-cell transplantation: an international case–control study. Blood 105(10):3802–3811

    PubMed  CAS  Google Scholar 

  • Cutler C, Henry NL, Magee C, Li S, Kim HT, Alyea E, Ho V, Lee SJ, Soiffer R, Antin JH (2005) Sirolimus and thrombotic microangiopathy after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 11(7):551–557

    PubMed  CAS  Google Scholar 

  • Dahllof G (1998) Craniofacial growth in children treated for malignant diseases. Acta Odontol Scand 56(6):378–382

    PubMed  CAS  Google Scholar 

  • Dahllof G, Barr M, Bolme P, Modeer T, Lonnqvist B, Ringden O, Heimdahl A (1988) Disturbances in dental development after total body irradiation in bone marrow transplant recipients. Oral Surg Oral Med Oral Pathol 65(1):41–44

    PubMed  CAS  Google Scholar 

  • Dahllof G, Rozell B, Forsberg CM, Borgstrom B (1994) Histologic changes in dental morphology induced by high dose chemotherapy and total body irradiation. Oral Surg Oral Med Oral Pathol 77(1):56–60

    PubMed  CAS  Google Scholar 

  • Dahllof G, Bagesund M, Remberger M, Ringden O (1997a) Risk factors for salivary dysfunction in children 1 year after bone marrow transplantation. Oral Oncol 33(5):327–331

    PubMed  CAS  Google Scholar 

  • Dahllof G, Bagesund M, Ringden O (1997b) Impact of conditioning regimens on salivary function, caries-associated microorganisms and dental caries in children after bone marrow transplantation. A 4-year longitudinal study. Bone Marrow Transplant 20(6):479–483

    PubMed  CAS  Google Scholar 

  • Damewood MD, Grochow LB (1986) Prospects for fertility after chemotherapy or radiation for neoplastic disease. Fertil Steril 45(4):443–459

    PubMed  CAS  Google Scholar 

  • Daniels MW, Wilson DM, Paguntalan HG, Hoffman AR, Bachrach LK (2003) Bone mineral density in pediatric transplant recipients. Transplantation 76(4):673–678

    PubMed  Google Scholar 

  • Deeg HJ, Flournoy N, Sullivan KM, Sheehan K, Buckner CD, Sanders JE, Storb R, Witherspoon RP, Thomas ED (1984) Cataracts after total body irradiation and marrow transplantation: a sparing effect of dose fractionation. Int J Radiat Oncol Biol Phys 10(7):957–964

    PubMed  CAS  Google Scholar 

  • Deeg HJ, Leisenring W, Storb R, Nims J, Flowers ME, Witherspoon RP, Sanders J, Sullivan KM (1998) Long-term outcome after marrow transplantation for severe aplastic anemia. Blood 91(10):3637–3645

    PubMed  CAS  Google Scholar 

  • Demarosi F, Lodi G, Carrassi A, Soligo D, Sardella A (2005a) Oral malignancies following HSCT: graft versus host disease and other risk factors. Oral Oncol 41(9):865–877

    PubMed  Google Scholar 

  • Demarosi F, Soligo D, Lodi G, Moneghini L, Sardella A, Carrassi A (2005b) Squamous cell carcinoma of the oral cavity associated with graft versus host disease: report of a case and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 100(1):63–69

    PubMed  Google Scholar 

  • Dignan FL, Scarisbrick JJ, Cornish J, Clark A, Amrolia P, Jackson G, Mahendra P, Taylor PC, Shah P, Lightman S, Fortune F, Kibbler C, Andreyev J, Albanese A, Hadzic N, Potter MN, Shaw BE (2012) Organ-specific management and supportive care in chronic graft-versus-host disease. Br J Haematol 158(1):62–78

    PubMed  CAS  Google Scholar 

  • Dunn JP, Jabs DA, Wingard J, Enger C, Vogelsang G, Santos G (1993) Bone marrow transplantation and cataract development. Arch Ophthalmol 111(10):1367–1373

    PubMed  CAS  Google Scholar 

  • Dvorak CC, Wright NB, Wong WB, Kristovich KM, Matthews EW, Weinberg KI, Amylon MD, Agarwal R (2008) Safety of hematopoietic stem cell transplantation in children less than three years of age. Pediatr Hematol Oncol 25(8):705–722. doi:10.1080/08880010802243524, 906490039 [pii]

    PubMed  CAS  Google Scholar 

  • Dvorak CC, Gracia CR, Sanders JE, Cheng EY, Baker KS, Pulsipher MA, Petryk A (2011) NCI, NHLBI/PBMTC first international conference on late effects after pediatric hematopoietic cell transplantation: endocrine challenges-thyroid dysfunction, growth impairment, bone health, & reproductive risks. Biol Blood Marrow Transplant 17(12):1725–1738. doi:10.1016/j.bbmt.2011.10.006, S1083-8791(11)00409-5 [pii]

    PubMed  Google Scholar 

  • Ebeling PR, Thomas DM, Erbas B, Hopper JL, Szer J, Grigg AP (1999) Mechanisms of bone loss following allogeneic and autologous hemopoietic stem cell transplantation. J Bone Miner Res 14(3):342–350

    PubMed  CAS  Google Scholar 

  • Fahnehjelm KT, Tornquist AL, Olsson M, Winiarski J (2007) Visual outcome and cataract development after allogeneic stem-cell transplantation in children. Acta Ophthalmol Scand 85(7):724–733

    PubMed  Google Scholar 

  • Fahnehjelm KT, Tornquist AL, Winiarski J (2008) Dry-eye syndrome after allogeneic stem-cell transplantation in children. Acta Ophthalmol 86(3):253–258

    PubMed  Google Scholar 

  • Faraci M, Bekassy AN, De Fazio V, Tichelli A, Dini G (2008) Non-endocrine late complications in children after allogeneic haematopoietic SCT. Bone Marrow Transplant 41(Suppl 2):S49–S57. doi:10.1038/bmt.2008.55, bmt200855 [pii]

    PubMed  CAS  Google Scholar 

  • Fehr T, Kahlert C, Fierz W, Joller-Jemelka HI, Riesen WF, Rickli H, Wuthrich RP, Ammann P (2004) Statin-induced immunomodulatory effects on human T cells in vivo. Atherosclerosis 175(1):83–90

    PubMed  CAS  Google Scholar 

  • Fink JC, Leisenring WM, Sullivan KM, Sherrard DJ, Weiss NS (1998) Avascular necrosis following bone marrow transplantation: a case–control study. Bone 22:67–71

    PubMed  CAS  Google Scholar 

  • Fletcher BD, Crom DB, Krance RA, Kun LE (1994) Radiation-induced bone abnormalities after bone marrow transplantation for childhood leukemia. Radiology 191(1):231–235

    PubMed  CAS  Google Scholar 

  • Fogo AB (2000) The role of angiotensin II and plasminogen activator inhibitor-1 in progressive glomerulosclerosis. Am J Kidney Dis 35(2):179–188

    PubMed  CAS  Google Scholar 

  • Frisk P, Hagberg H, Mandahl A, Soderberg P, Lonnerholm G (2000) Cataracts after autologous bone marrow transplantation in children. Acta Paediatr 89(7):814–819

    PubMed  CAS  Google Scholar 

  • Frisk P, Bratteby LE, Carlson K, Lonnerholm G (2002) Renal function after autologous bone marrow transplantation in children: a long-term prospective study. Bone Marrow Transplant 29(2):129–136

    PubMed  CAS  Google Scholar 

  • Frisk P, Arvidson J, Gustafsson J, Lonnerholm G (2004) Pubertal development and final height after autologous bone marrow transplantation for acute lymphoblastic leukemia. Bone Marrow Transplant 33(2):205–210. doi:10.1038/sj.bmt.1704324

    PubMed  CAS  Google Scholar 

  • Frisk P, Arvidson J, Ljunggren O, Gustafsson J (2011) Decreased bone mineral density in young adults treated with SCT in childhood: the role of 25-hydroxyvitamin D. Bone Marrow Transplant. doi:10.1038/bmt.2011.147, bmt2011147 [pii]

    Google Scholar 

  • Fuge R, Bird JM, Fraser A, Hart D, Hunt L, Cornish JM, Goulden N, Oakhill A, Pamphilon DH, Steward CG, Marks DI (2001) The clinical features, risk factors and outcome of thrombotic thrombocytopenic purpura occurring after bone marrow transplantation. Br J Haematol 113(1):58–64

    PubMed  CAS  Google Scholar 

  • Gallagher G, Forrest DL (2007) Second solid cancers after allogeneic hematopoietic stem cell transplantation. Cancer 109(1):84–92

    PubMed  Google Scholar 

  • Galotto M, Berisso G, Delfino L, Podesta M, Ottaggio L, Dallorso S, Dufour C, Ferrara GB, Abbondandolo A, Dini G, Bacigalupo A, Cancedda R, Quarto R (1999) Stromal damage as consequence of high-dose chemo/radiotherapy in bone marrow transplant recipients. Exp Hematol 27(9):1460–1466

    PubMed  CAS  Google Scholar 

  • Gaziev D, Baronciani D, Galimberti M, Polchi P, Angelucci E, Giardini C, Muretto P, Perugini S, Riggio S, Ghirlanda S, Erer B, Maiello A, Lucarelli G (1996) Mucormycosis after bone marrow transplantation: report of four cases in thalassemia and review of the literature. Bone Marrow Transplant 17(3):409–414

    PubMed  CAS  Google Scholar 

  • Geenen MM, Cardous-Ubbink MC, Kremer LC, van den Bos C, van der Pal HJ, Heinen RC, Jaspers MW, Koning CC, Oldenburger F, Langeveld NE, Hart AA, Bakker PJ, Caron HN, van Leeuwen FE (2007) Medical assessment of adverse health outcomes in long-term survivors of childhood cancer. JAMA 297(24):2705–2715. doi:10.1001/jama.297.24.2705, 297/24/2705 [pii]

    PubMed  CAS  Google Scholar 

  • Giorgiani G, Bozzola M, Locatelli F, Picco P, Zecca M, Cisternino M, Dallorso S, Bonetti F, Dini G, Borrone C et al (1995) Role of busulfan and total body irradiation on growth of prepubertal children receiving bone marrow transplantation and results of treatment with recombinant human growth hormone. Blood 86(2):825–831

    PubMed  CAS  Google Scholar 

  • Goldberg RJ, Nakagawa T, Johnson RJ, Thurman JM (2010) The role of endothelial cell injury in thrombotic microangiopathy. Am J Kidney Dis 56(6): 1168–1174

    PubMed  Google Scholar 

  • Gooley TA, Chien JW, Pergam SA, Hingorani S, Sorror ML, Boeckh M, Martin PJ, Sandmaier BM, Marr KA, Appelbaum FR, Storb R, McDonald GB (2010) Reduced mortality after allogeneic hematopoietic-cell transplantation. N Engl J Med 363(22):2091–2101. doi:10.1056/NEJMoa1004383

    PubMed  CAS  Google Scholar 

  • Gordon CM, Bachrach LK, Carpenter TO, Crabtree N, El-Hajj Fuleihan G, Kutilek S, Lorenc RS, Tosi LL, Ward KA, Ward LM, Kalkwarf HJ (2008) Dual energy X-ray absorptiometry interpretation and reporting in children and adolescents: the 2007 ISCD Pediatric Official Positions. J Clin Densitom 11(1):43–58. doi:10.1016/j.jocd.2007.12.005, S1094-6950(07)00253-3 [pii]

    PubMed  Google Scholar 

  • Grigg AP, Bhathal PS (2001) Compound heterozygosity for haemochromatosis gene mutations and hepatic iron overload in allogeneic bone marrow transplant recipients. Pathology 33(1):44–49

    PubMed  CAS  Google Scholar 

  • Grigg AP, Angus PW, Hoyt R, Szer J (2003) The incidence, pathogenesis and natural history of steatorrhea after bone marrow transplantation. Bone Marrow Transplant 31(8):701–703

    PubMed  CAS  Google Scholar 

  • Grigg AP, Shuttleworth P, Reynolds J, Schwarer AP, Szer J, Bradstock K, Hui C, Herrmann R, Ebeling PR (2006) Pamidronate reduces bone loss after allogeneic stem cell transplantation. J Clin Endocrinol Metab 91(10):3835–3843. doi:10.1210/jc.2006-0684, jc.2006-0684 [pii]

    PubMed  CAS  Google Scholar 

  • Gronroos MH, Bolme P, Winiarski J, Berg UB (2007) Long-term renal function following bone marrow transplantation. Bone Marrow Transplant 39(11):717–723

    PubMed  CAS  Google Scholar 

  • Gungor I, Schor K, Rosenthal P, Jacobs DS (2008) The Boston Scleral Lens in the treatment of pediatric patients. J AAPOS 12(3):263–267. doi:10.1016/j.jaapos.2007.11.008, S1091-8531(07)00546-0 [pii]

    PubMed  Google Scholar 

  • Gurgan C, Ozcan M, Karakus O, Zincircioglu G, Arat M, Soydan E, Topcuoglu P, Gurman G, Bostanci H (2012) Periodontal status and post-transplantation complications following intensive periodontal treatment in patients underwent allogenic hematopoietic stem cell transplantation conditioned with myeloablative regimen. Int J Dent Hyg 11(2):84–90

    PubMed  Google Scholar 

  • Hamon MD, Gale RF, Macdonald ID, Smith OP, Collis CH, Skeggs DB, Gandhi L, Prentice HG (1993) Incidence of cataracts after single fraction total body irradiation: the role of steroids and graft versus host disease. Bone Marrow Transplant 12(3):233–236

    PubMed  CAS  Google Scholar 

  • Harder H, Van Gool AR, Duivenvoorden HJ, Cornelissen JJ, Eijkenboom WM, Barge RM, van den Bent MJ (2007) Case-referent comparison of cognitive functions in patients receiving haematopoietic stem-cell transplantation for haematological malignancies: two-year follow-up results. Eur J Cancer 43(14):2052–2059. doi:10.1016/j.ejca.2007.06.005, S0959-8049(07)00486-8 [pii]

    PubMed  Google Scholar 

  • Hingorani S (2006) Chronic kidney disease in long-term survivors of hematopoietic cell transplantation: epidemiology, pathogenesis, and treatment. J Am Soc Nephrol 17(7):1995–2005

    PubMed  Google Scholar 

  • Hingorani S (2008) Chronic kidney disease after pediatric hematopoietic cell transplant. Biol Blood Marrow Transplant 14(1 Suppl 1):84–87

    PubMed  Google Scholar 

  • Hingorani S, Guthrie KA, Schoch G, Weiss NS, McDonald GB (2007) Chronic kidney disease in long-term survivors of hematopoietic cell transplant. Bone Marrow Transplant 39(4):223–229

    PubMed  CAS  Google Scholar 

  • Ho VT, Cutler C, Carter S, Martin P, Adams R, Horowitz M, Ferrara J, Soiffer R, Giralt S (2005) Blood and marrow transplant clinical trials network toxicity committee consensus summary: thrombotic microangiopathy after hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 11(8):571–575

    PubMed  Google Scholar 

  • Hoffmeister PA, Storer BE, Sanders JE (2004) Diabetes mellitus in long-term survivors of pediatric hematopoietic cell transplantation. J Pediatr Hematol Oncol 26(2):81–90

    PubMed  Google Scholar 

  • Holdaas H, Fellstrom B, Jardine AG, Holme I, Nyberg G, Fauchald P, Gronhagen-Riska C, Madsen S, Neumayer HH, Cole E, Maes B, Ambuhl P, Olsson AG, Hartmann A, Solbu DO, Pedersen TR, Assessment of LiRTSI (2003) Effect of fluvastatin on cardiac outcomes in renal transplant recipients: a multicentre, randomised, placebo-controlled trial. Lancet 361(9374):2024–2031

    PubMed  CAS  Google Scholar 

  • Holmstrom G, Borgstrom B, Calissendorff B (2002) Cataract in children after bone marrow transplantation: relation to conditioning regimen. Acta Ophthalmol Scand 80(2):211–215

    PubMed  Google Scholar 

  • Holtta P, Hovi L, Saarinen-Pihkala UM, Peltola J, Alaluusua S (2005) Disturbed root development of permanent teeth after pediatric stem cell transplantation. Dental root development after SCT. Cancer 103(7):1484–1493

    PubMed  Google Scholar 

  • Howell SJ, Shalet SM (2005) Spermatogenesis after cancer treatment: damage and recovery. J Natl Cancer Inst Monogr 34:12–17. doi:10.1093/jncimonographs/lgi003, 2005/34/12 [pii]

    PubMed  CAS  Google Scholar 

  • Huma Z, Boulad F, Black P, Heller G, Sklar C (1995) Growth in children after bone marrow transplantation for acute leukemia. Blood 86(2):819–824

    PubMed  CAS  Google Scholar 

  • Imanguli MM, Pavletic SZ, Guadagnini JP, Brahim JS, Atkinson JC (2006) Chronic graft versus host disease of oral mucosa: review of available therapies. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101(2):175–183

    PubMed  Google Scholar 

  • Ioannou GN, Splan MF, Weiss NS, McDonald GB, Beretta L, Lee SP (2007) Incidence and predictors of hepatocellular carcinoma in patients with cirrhosis. Clin Gastroenterol Hepatol 5(8):938–945, 945, e931–934

    PubMed  Google Scholar 

  • Ishiguro H, Yasuda Y, Tomita Y, Shinagawa T, Shimizu T, Morimoto T, Hattori K, Matsumoto M, Inoue H, Yabe H, Yabe M, Shinohara O, Kato S (2004) Long-term follow-up of thyroid function in patients who received bone marrow transplantation during childhood and adolescence. J Clin Endocrinol Metab 89(12):5981–5986. doi:10.1210/jc.2004-0836, 89/12/5981 [pii]

    PubMed  CAS  Google Scholar 

  • Jacobs SR, Small BJ, Booth-Jones M, Jacobsen PB, Fields KK (2007) Changes in cognitive functioning in the year after hematopoietic stem cell transplantation. Cancer 110(7):1560–1567. doi:10.1002/cncr.22962

    PubMed  Google Scholar 

  • Jastaniah W, Harmatz P, Pakbaz Z, Fischer R, Vichinsky E, Walters MC (2008) Transfusional iron burden and liver toxicity after bone marrow transplantation for acute myelogenous leukemia and hemoglobinopathies. Pediatr Blood Cancer 50(2):319–324

    PubMed  Google Scholar 

  • Jones LR, Toth BB, Keene HJ (1992) Effects of total body irradiation on salivary gland function and caries-associated oral microflora in bone marrow transplant patients. Oral Surg Oral Med Oral Pathol 73(6):670–676

    PubMed  CAS  Google Scholar 

  • Jurges E, el Tumi M, O'Donohue J, Hobbs J (1991) Pancreatic insufficiency after bone-marrow transplantation. Lancet 338(8765):517

    PubMed  CAS  Google Scholar 

  • Kamble RT, Chang CC, Sanchez S, Carrum G (2007) Central nervous system graft-versus-host disease: report of two cases and literature review. Bone Marrow Transplant 39(1):49–52

    PubMed  CAS  Google Scholar 

  • Kami M, Tanaka Y, Chiba S, Matsumura T, Machida U, Kanda Y, Nakagawa K, Mitsuhashi T, Hirai H (2001) Thyroid function after bone marrow transplantation: possible association between immune-mediated thyrotoxicosis and hypothyroidism. Transplantation 71(3):406–411

    PubMed  CAS  Google Scholar 

  • Kananen K, Volin L, Laitinen K, Alfthan H, Ruutu T, Valimaki MJ (2005) Prevention of bone loss after allogeneic stem cell transplantation by calcium, vitamin D, and sex hormone replacement with or without pamidronate. J Clin Endocrinol Metab 90(7):3877–3885. doi:10.1210/jc.2004-2161, jc.2004-2161 [pii]

    PubMed  CAS  Google Scholar 

  • Kanda J, Kawabata H, Chao NJ (2011) Iron overload and allogeneic hematopoietic stem-cell transplantation. Expert Rev Hematol 4(1):71–80

    PubMed  CAS  Google Scholar 

  • Kang MI, Lee WY, Oh KW, Han JH, Song KH, Cha BY, Lee KW, Son HY, Kang SK, Kim CC (2000) The short-term changes of bone mineral metabolism following bone marrow transplantation. Bone 26(3):275–279

    PubMed  CAS  Google Scholar 

  • Kanis JA, McCloskey EV, Johansson H, Oden A, Melton LJ 3rd, Khaltaev N (2008) A reference standard for the description of osteoporosis. Bone 42(3):467–475. doi:10.1016/j.bone.2007.11.001, S8756-3282(07)00823-X [pii]

    PubMed  CAS  Google Scholar 

  • Kaste SC, Shidler TJ, Tong X, Srivastava DK, Rochester R, Hudson MM, Shearer PD, Hale GA (2004) Bone mineral density and osteonecrosis in survivors of childhood allogeneic bone marrow transplantation. Bone Marrow Transplant 33(4):435–441

    PubMed  CAS  Google Scholar 

  • Kaste SC, Goodman P, Leisenring W, Stovall M, Hayashi RJ, Yeazel M, Beiraghi S, Hudson MM, Sklar CA, Robison LL, Baker KS (2009) Impact of radiation and chemotherapy on risk of dental abnormalities: a report from the Childhood Cancer Survivor Study. Cancer 115(24):5817–5827

    PubMed  Google Scholar 

  • Katsanis E, Shapiro RS, Robison LL, Haake RJ, Kim T, Pescovitz OH, Ramsay NK (1990) Thyroid dysfunction following bone marrow transplantation: long-term follow-up of 80 pediatric patients. Bone Marrow Transplant 5(5):335–340

    PubMed  CAS  Google Scholar 

  • Kersting S, Hene RJ, Koomans HA, Verdonck LF (2007a) Chronic kidney disease after myeloablative allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 13(10):1169–1175

    PubMed  Google Scholar 

  • Kersting S, Koomans HA, Hene RJ, Verdonck LF (2007b) Acute renal failure after allogeneic myeloablative stem cell transplantation: retrospective analysis of incidence, risk factors and survival. Bone Marrow Transplant 39(6):359–365

    PubMed  CAS  Google Scholar 

  • Khoshniat M, Ghavamzadeh A, Larijani B, Bahar B, Tabatabaei O (2003) Effect on growth parameters of bone marrow transplantation with a chemotherapy-only conditioning regimen. Transplant Proc 35(8):3085–3088, S0041134503011266 [pii]

    PubMed  CAS  Google Scholar 

  • Kim YR, Kim JS, Cheong JW, Song JW, Min YH (2008) Transfusion-associated iron overload as an adverse risk factor for transplantation outcome in patients undergoing reduced-intensity stem cell transplantation for myeloid malignancies. Acta Haematol 120(3):182–189

    PubMed  Google Scholar 

  • Kim JY, Lee MY, Kim B, Park CW, Chang YS, Chung S (2010) Membranoproliferative glomerulonephritis following allogeneic hematopoietic stem cell transplantation. Clin Exp Nephrol 14(6):630–632

    PubMed  Google Scholar 

  • Kist-van Holthe JE, van Zwet JM, Brand R, van Weel MH, Vossen JM, van der Heijden AJ (1998) Bone marrow transplantation in children: consequences for renal function shortly after and 1 year post-BMT. Bone Marrow Transplant 22(6):559–564

    PubMed  CAS  Google Scholar 

  • Koc S, Leisenring W, Flowers MED, Anasetti C, Deeg HJ, Nash RA, Sanders JE, Witherspoon RP, Storb R, Appelbaum FR, Martin PJ (2002) Therapy for chronic graft-versus-host disease: a randomized trial comparing cyclosporine plus prednisone versus prednisone alone. Blood 100(1):48–51

    PubMed  CAS  Google Scholar 

  • Kolb HJ, Socie G, Duell T, Van Lint MT, Tichelli A, Apperley JF, Nekolla E, Ljungman P, Jacobsen N, van Weel M, Wick R, Weiss M, Prentice HG (1999) Malignant neoplasms in long-term survivors of bone marrow transplantation. Late Effects Working Party of the European Cooperative Group for Blood and Marrow Transplantation and the European Late Effect Project Group. Ann Intern Med 131(10):738–744, 199911160–00004 [pii]

    PubMed  CAS  Google Scholar 

  • Kontoyiannis DP, Chamilos G, Lewis RE, Giralt S, Cortes J, Raad II, Manning JT, Han X (2007) Increased bone marrow iron stores is an independent risk factor for invasive aspergillosis in patients with high-risk hematologic malignancies and recipients of allogeneic hematopoietic stem cell transplantation. Cancer 110(6):1303–1306

    PubMed  Google Scholar 

  • Koo KH, Kim R, Ko GH, Song HR, Jeong ST, Cho SH (1995) Preventing collapse in early osteonecrosis of the femoral head. A randomised clinical trial of core decompression. J Bone Joint Surg Br Vol 77(6):870–874

    CAS  Google Scholar 

  • Kramer JH, Crittenden MR, DeSantes K, Cowan MJ (1997) Cognitive and adaptive behavior 1 and 3 years following bone marrow transplantation. Bone Marrow Transplant 19(6):607–613. doi:10.1038/sj.bmt.1700699

    PubMed  CAS  Google Scholar 

  • Kremer LC, van Dalen EC, Offringa M, Voute PA (2002a) Frequency and risk factors of anthracycline-induced clinical heart failure in children: a systematic review. Ann Oncol 13(4):503–512

    PubMed  CAS  Google Scholar 

  • Kremer LC, van der Pal HJ, Offringa M, van Dalen EC, Voute PA (2002b) Frequency and risk factors of subclinical cardiotoxicity after anthracycline therapy in children: a systematic review. Ann Oncol 13(6):819–829

    PubMed  CAS  Google Scholar 

  • Lai KA, Shen WJ, Yang CY, Shao CJ, Hsu JT, Lin RM (2005) The use of alendronate to prevent early collapse of the femoral head in patients with nontraumatic osteonecrosis. A randomized clinical study. J Bone Joint Surg Am Vol 87(10):2155–2159

    Google Scholar 

  • Lakka HM, Laaksonen DE, Lakka TA, Niskanen LK, Kumpusalo E, Tuomilehto J, Salonen JT (2002) The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA 288(21): 2709–2716

    PubMed  Google Scholar 

  • Laporte S, Couto-Silva AC, Trabado S, Lemaire P, Brailly-Tabard S, Esperou H, Michon J, Baruchel A, Fischer A, Trivin C, Brauner R (2011) Inhibin B and anti-Mullerian hormone as markers of gonadal function after hematopoietic cell transplantation during childhood. BMC Pediatr 11:20. doi:10.1186/1471-2431-11-20, 1471-2431-11-20 [pii]

    PubMed  Google Scholar 

  • Laskin BL, Goebel J, Davies SM, Jodele S (2011) Small vessels, big trouble in the kidneys and beyond: hematopoietic stem cell transplantation-associated thrombotic microangiopathy. Blood 118(6):1452–1462

    PubMed  CAS  Google Scholar 

  • Lawton CA, Cohen EP, Barber-Derus SW, Murray KJ, Ash RC, Casper JT, Moulder JE (1991) Late renal dysfunction in adult survivors of bone marrow transplantation. Cancer 67(11):2795–2800

    PubMed  CAS  Google Scholar 

  • Lawton CA, Fish BL, Moulder JE (1994) Effect of nephrotoxic drugs on the development of radiation nephropathy after bone marrow transplantation. Int J Radiat Oncol Biol Phys 28(4):883–889

    PubMed  CAS  Google Scholar 

  • Lee WY, Oh ES, Min CK, Kim DW, Lee JW, Kang MI, Min WS, Cha BY, Lee KW, Son HY, Kang SK, Kim CC (2001) Changes in autoimmune thyroid disease following allogeneic bone marrow transplantation. Bone Marrow Transplant 28(1):63–66. doi:10.1038/sj.bmt.1703102

    PubMed  CAS  Google Scholar 

  • Lee WY, Cho SW, Oh ES, Oh KW, Lee JM, Yoon KH, Kang MI, Cha BY, Lee KW, Son HY, Kang SK, Kim CC (2002) The effect of bone marrow transplantation on the osteoblastic differentiation of human bone marrow stromal cells. J Clin Endocrinol Metab 87(1):329–335

    PubMed  CAS  Google Scholar 

  • Lee WY, Baek KH, Rhee EJ, Tae HJ, Oh KW, Kang MI, Lee KW, Kim SW, Kim CC, Oh ES (2004) Impact of circulating bone-resorbing cytokines on the subsequent bone loss following bone marrow transplantation. Bone Marrow Transplant 34(1):89–94. doi:10.1038/sj.bmt.1704535, 1704535 [pii]

    PubMed  CAS  Google Scholar 

  • Lee JW, Kang HJ, Kim EK, Kim H, Shin HY, Ahn HS (2009) Effect of iron overload and iron-chelating therapy on allogeneic hematopoietic SCT in children. Bone Marrow Transplant 44(12):793–797

    PubMed  CAS  Google Scholar 

  • Leiper AD, Stanhope R, Lau T, Grant DB, Blacklock H, Chessells JM, Plowman PN (1987) The effect of total body irradiation and bone marrow transplantation during childhood and adolescence on growth and endocrine function. Br J Haematol 67(4):419–426

    PubMed  CAS  Google Scholar 

  • Leung W, Ahn H, Rose SR, Phipps S, Smith T, Gan K, O'Connor M, Hale GA, Kasow KA, Barfield RC, Madden RM, Pui CH (2007) A prospective cohort study of late sequelae of pediatric allogeneic hematopoietic stem cell transplantation. Medicine (Baltimore) 86(4):215–224. doi:10.1097/MD.0b013e31812f864d, 00005792-200707000-00004 [pii]

    Google Scholar 

  • Lin J, Markowitz GS, Nicolaides M, Hesdorffer CS, Appel GB, D'Agati VD, Savage DG (2001) Membranous glomerulopathy associated with graft-versus-host disease following allogeneic stem cell transplantation. Report of 2 cases and review of the literature. Am J Nephrol 21(5):351–356

    PubMed  CAS  Google Scholar 

  • Lin SC, Jen YM, Chang YC, Lin CC (2008) Assessment of xerostomia and its impact on quality of life in head and neck cancer patients undergoing radiotherapy, and validation of the Taiwanese version of the xerostomia questionnaire. J Pain Symptom Manage 36(2):141–148

    PubMed  Google Scholar 

  • Llamas P, Romero R, Cabrera R, Sanjuan I, Fores R, Fernandez MN (1997) Management of thrombotic microangiopathy following allogeneic transplantation: what is the role of plasma exchange? Bone Marrow Transplant 20(4):305–306

    PubMed  CAS  Google Scholar 

  • Lof CM, Winiarski J, Giesecke A, Ljungman P, Forinder U (2009) Health-related quality of life in adult survivors after paediatric allo-SCT. Bone Marrow Transplant 43(6):461–468. doi:10.1038/bmt.2008.338, bmt2008338 [pii]

    PubMed  CAS  Google Scholar 

  • Lonnerholm G, Carlson K, Bratteby LE, Backlund L, Hagberg H, Rikner G, Smedmyr B, Oberg G, Simonsson B (1991) Renal function after autologous bone marrow transplantation. Bone Marrow Transplant 8(2):129–134

    PubMed  CAS  Google Scholar 

  • Loren AW, Chow E, Jacobsohn DA, Gilleece M, Halter J, Joshi S, Wang Z, Sobocinski KA, Gupta V, Hale GA, Marks DI, Stadtmauer EA, Apperley J, Cahn JY, Schouten HC, Lazarus HM, Savani BN, McCarthy PL, Jakubowski AA, Kamani NR, Hayes-Lattin B, Maziarz RT, Warwick AB, Sorror ML, Bolwell BJ, Socie G, Wingard JR, Rizzo JD, Majhail NS (2011) Pregnancy after hematopoietic cell transplantation: a report from the late effects working committee of the Center for International Blood and Marrow Transplant Research (CIBMTR). Biol Blood Marrow Transplant 17(2):157–166. doi:10.1016/j.bbmt.2010.07.009, S1083-8791(10)00300-9 [pii]

    PubMed  Google Scholar 

  • Lorini R, Cortona L, Scaramuzza A, De Stefano P, Locatelli F, Bonetti F, Severi F (1995) Hyperinsulinemia in children and adolescents after bone marrow transplantation. Bone Marrow Transplant 15(6):873–877

    PubMed  CAS  Google Scholar 

  • Luo XD, Liu QF, Zhang Y, Sun J, Wang GB, Fan ZP, Yi ZS, Ling YW, Wei YQ, Liu XL, Xu B (2011) Nephrotic syndrome after allogeneic hematopoietic stem cell transplantation: etiology and pathogenesis. Blood Cells Mol Dis 46(2):182–187

    PubMed  Google Scholar 

  • Majhail NS, Lazarus HM, Burns LJ (2008) Iron overload in hematopoietic cell transplantation. Bone Marrow Transplant 41(12):997–1003

    PubMed  CAS  Google Scholar 

  • Majhail NS, Challa TR, Mulrooney DA, Baker KS, Burns LJ (2009) Hypertension and diabetes mellitus in adult and pediatric survivors of allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant 15(9):1100–1107. doi:10.1016/j.bbmt.2009.05.010, S1083-8791(09)00249-3 [pii]

    PubMed  CAS  Google Scholar 

  • Majhail NS, Rizzo JD, Lee SJ, Aljurf M, Atsuta Y, Bonfim C, Burns LJ, Chaudhri N, Davies S, Okamoto S, Seber A, Socie G, Szer J, Van Lint MT, Wingard JR, Tichelli A (2012) Recommended screening and preventive practices for long-term survivors after hematopoietic cell transplantation. Biol Blood Marrow Transplant 18(3):348–371. doi:10.1016/j.bbmt.2011.12.519, S1083-8791(11)01081-0 [pii]

    PubMed  Google Scholar 

  • Manenti F, Galimberti M, Lucarelli G, Polchi P, De Sanctis V, Tanas R, Vullo C, Ruggiero L (1989) Growth and endocrine function after bone marrow transplantation for thalassemia major. Prog Clin Biol Res 309:273–280

    PubMed  CAS  Google Scholar 

  • Marazuela M, Steegman JL (2000) Transfer of auto-immune hypothyroidism following bone marrow transplantation from a donor with Graves' disease. Bone Marrow Transplant 26(11):1217–1220. doi:10.1038/sj.bmt.1702676

  • Markowitz GS, Appel GB, Fine PL, Fenves AZ, Loon NR, Jagannath S, Kuhn JA, Dratch AD, D'Agati VD (2001) Collapsing focal segmental glomerulosclerosis following treatment with high-dose pamidronate. J Am Soc Nephrol 12(6):1164–1172

    PubMed  CAS  Google Scholar 

  • Marr H, McDonald EJ, Merriman E, Smith M, Mangos H, Stoddart C, Ganly P (2009) Successful treatment of transplant-associated microangiopathy with rituximab. N Z Med J 122(1292):72–74

    PubMed  Google Scholar 

  • Marshall D, Johnell O, Wedel H (1996) Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. BMJ 312(7041):1254–1259

    PubMed  CAS  Google Scholar 

  • Martin PJ, Counts GW Jr, Appelbaum FR, Lee SJ, Sanders JE, Deeg HJ, Flowers ME, Syrjala KL, Hansen JA, Storb RF, Storer BE (2010) Life expectancy in patients surviving more than 5 years after hematopoietic cell transplantation. J Clin Oncol 28(6):1011–1016. doi:10.1200/JCO.2009.25.6693, JCO.2009.25.6693 [pii]

    PubMed  Google Scholar 

  • Mattison GR, Glazer GM, Quint LE, Francis IR, Bree RL, Ensminger WD (1987) MR imaging of hepatic focal nodular hyperplasia: characterization and distinction from primary malignant hepatic tumors. AJR Am J Roentgenol 148(4):711–715

    PubMed  CAS  Google Scholar 

  • Mawardi H, Elad S, Correa ME, Stevenson K, Woo SB, Almazrooa S, Haddad R, Antin JH, Soiffer R, Treister N (2011) Oral epithelial dysplasia and squamous cell carcinoma following allogeneic hematopoietic stem cell transplantation: clinical presentation and treatment outcomes. Bone Marrow Transplant 46(6):884–891

    PubMed  CAS  Google Scholar 

  • Mayer EI, Dopfer RE, Klingebiel T, Scheel-Walter H, Ranke MB, Niethammer D (1999) Longitudinal gonadal function after bone marrow transplantation for acute lymphoblastic leukemia during childhood. Pediatr Transplant 3(1):38–44

    PubMed  CAS  Google Scholar 

  • McClune BL, Polgreen LE, Burmeister LA, Blaes AH, Mulrooney DA, Burns LJ, Majhail NS (2011) Screening, prevention and management of osteoporosis and bone loss in adult and pediatric hematopoietic cell transplant recipients. Bone Marrow Transplant 46(1):1–9. doi:10.1038/bmt.2010.198, bmt2010198 [pii]

    PubMed  CAS  Google Scholar 

  • McDonald GB, Sullivan KM, Schuffler MD, Shulman HM, Thomas ED (1981) Esophageal abnormalities in chronic graft-versus-host disease in humans. Gastroenterology 80(5 pt 1):914–921

    PubMed  CAS  Google Scholar 

  • McDonald GB, Sullivan KM, Plumley TF (1984) Radiographic features of esophageal involvement in chronic graft-vs.-host disease. AJR Am J Roentgenol 142(3):501–506

    PubMed  CAS  Google Scholar 

  • Mertens AC, Yasui Y, Neglia JP, Potter JD, Nesbit MEJ, Ruccione K, Smithson WA, Robison LL (2001) Late mortality experience in five-year survivors of childhood and adolescent cancer: the Childhood Cancer Survivor Study. J Clin Oncol 19(13):3163–3172

    PubMed  CAS  Google Scholar 

  • Miceli MH, Dong L, Grazziutti ML, Fassas A, Thertulien R, Van Rhee F, Barlogie B, Anaissie EJ (2006) Iron overload is a major risk factor for severe infection after autologous stem cell transplantation: a study of 367 myeloma patients. Bone Marrow Transplant 37(9):857–864

    PubMed  CAS  Google Scholar 

  • Michel G, Socie G, Gebhard F, Bernaudin F, Thuret I, Vannier JP, Demeocq F, Leverger G, Pico JL, Rubie H, Mechinaud F, Reiffers J, Gratecos N, Troussard X, Jouet JP, Simonin G, Gluckman E, Maraninchi D (1997) Late effects of allogeneic bone marrow transplantation for children with acute myeloblastic leukemia in first complete remission: the impact of conditioning regimen without total-body irradiation–a report from the Societe Francaise de Greffe de Moelle. J Clin Oncol 15(6):2238–2246

    PubMed  CAS  Google Scholar 

  • Mielcarek M, Martin PJ, Leisenring W, Flowers ME, Maloney DG, Sandmaier BM, Maris MB, Storb R (2003) Graft-versus-host disease after nonmyeloablative versus conventional hematopoietic stem cell transplantation. Blood 102(2):756–762

    PubMed  CAS  Google Scholar 

  • Minocha A, Mandanas RA, Kida M, Jazzar A (1997) Bullous esophagitis due to chronic graft-versus-host disease. Am J Gastroenterol 92(3):529–530

    PubMed  CAS  Google Scholar 

  • Moake JL (2002) Thrombotic microangiopathies. N Engl J Med 347(8):589–600

    PubMed  CAS  Google Scholar 

  • Mont MA, Carbone JJ, Fairbank AC (1996) Core decompression versus nonoperative management for osteonecrosis of the hip (Review). Clin Orthop Relat Res 324:169–178

    PubMed  Google Scholar 

  • Mostoufi-Moab S, Ginsberg JP, Bunin N, Zemel B, Shults J, Leonard MB (2011) Bone density and structure in long-term survivors of pediatric allogeneic hematopoietic stem cell transplantation. J Bone Miner Res. doi:10.1002/jbmr.1499

    Google Scholar 

  • Nakshabendi IM, Maldonado ME, Coppola D, Mamel JJ (2000) Esophageal cast: a manifestation of graft-versus-host disease. Dig Dis 18(2):103–105

    PubMed  CAS  Google Scholar 

  • Neofytos D, Ojha A, Mookerjee B, Wagner J, Filicko J, Ferber A, Dessain S, Grosso D, Brunner J, Flomenberg N, Flomenberg P (2007) Treatment of adenovirus disease in stem cell transplant recipients with cidofovir. Biol Blood Marrow Transplant 13(1):74–81

    PubMed  CAS  Google Scholar 

  • Ness KK, Bhatia S, Baker KS, Francisco L, Carter A, Forman SJ, Robison LL, Rosenthal J, Gurney JG (2005) Performance limitations and participation restrictions among childhood cancer survivors treated with hematopoietic stem cell transplantation: the bone marrow transplant survivor study. Arch Pediatr Adolesc Med 159(8):706–713. doi:10.1001/archpedi.159.8.706, 159/8/706 [pii]

    PubMed  Google Scholar 

  • Ng JS, Lam DS, Li CK, Chik KW, Cheng GP, Yuen PM, Tso MO (1999) Ocular complications of pediatric bone marrow transplantation. Ophthalmology 106(1):160–164

    PubMed  CAS  Google Scholar 

  • Nicolatou-Galitis O, Kitra V, Van Vliet-Constantinidou C, Peristeri J, Goussetis E, Petropoulos D, Grafakos S (2001) The oral manifestations of chronic graft-versus-host disease (cGVHD) in paediatric allogeneic bone marrow transplant recipients. J Oral Pathol Med 30(3):148–153

    PubMed  CAS  Google Scholar 

  • Nouri-Majelan N, Sanadgol H, Ghafari A, Rahimian M, Najafi F, Mortazavizadeh M, Moghaddasi S (2005) Antineutrophil cytoplasmic antibody-associated glomerulonephritis in chronic graft-versus-host disease after allogenic hematopoietic stem cell transplantation. Transplant Proc 37(7):3213–3215

    PubMed  CAS  Google Scholar 

  • Nuver J, Smit AJ, Postma A, Sleijfer DT, Gietema JA (2002) The metabolic syndrome in long-term cancer survivors, an important target for secondary preventive measures. Cancer Treat Rev 28(4):195–214

    PubMed  CAS  Google Scholar 

  • Nysom K, Holm K, Michaelsen KF, Hertz H, Jacobsen N, Muller J, Molgaard C (2000) Bone mass after allogeneic BMT for childhood leukaemia or lymphoma. Bone Marrow Transplant 25(2):191–196

    PubMed  CAS  Google Scholar 

  • Ogilvy-Stuart AL, Clark DJ, Wallace WH, Gibson BE, Stevens RF, Shalet SM, Donaldson MD (1992) Endocrine deficit after fractionated total body irradiation. Arch Dis Childhood 67(9):1107–1110

    CAS  Google Scholar 

  • Oliveira JS, Bahia D, Franco M, Balda C, Stella S, Kerbauy J (1999) Nephrotic syndrome as a clinical manifestation of graft-versus-host disease (GVHD) in a marrow transplant recipient after cyclosporine withdrawal. Bone Marrow Transplant 23(1):99–101

    PubMed  CAS  Google Scholar 

  • Olivieri NF, Brittenham GM (1997) Iron-chelating therapy and the treatment of thalassemia. Blood 89(3): 739–761

    PubMed  CAS  Google Scholar 

  • O'Rourke B, Barbir M, Mitchell AG, Yacoub MH, Banner NR (2004) Efficacy and safety of fluvastatin therapy for hypercholesterolemia after heart transplantation: results of a randomised double blind placebo controlled study. Int J Cardiol 94(2–3):235–240

    PubMed  Google Scholar 

  • Palmas A, Tefferi A, Myers JL, Scott JP, Swensen SJ, Chen MG, Gastineau DA, Gertz MA, Inwards DJ, Lacy MQ, Litzow MR (1998) Late-onset noninfectious pulmonary complications after allogeneic bone marrow transplantation. Br J Haematol 100(4):680–687

    PubMed  CAS  Google Scholar 

  • Papadimitriou A, Urena M, Hamill G, Stanhope R, Leiper AD (1991) Growth hormone treatment of growth failure secondary to total body irradiation and bone marrow transplantation. Arch Dis Childhood 66(6):689–692

    CAS  Google Scholar 

  • Parsons SK, Phipps S, Sung L, Baker KS, Pulsipher MA, Ness KK (2012) NCI, NHLBI/PBMTC First International Conference on Late Effects after Pediatric Hematopoietic Cell Transplantation: health-related quality of life, functional, and neurocognitive outcomes. Biol Blood Marrow Transplant 18(2):162–171. doi:10.1016/j.bbmt.2011.12.501, S1083-8791(11)01063-9 [pii]

    PubMed  Google Scholar 

  • Peffault de Latour R, Levy V, Asselah T, Marcellin P, Scieux C, Ades L, Traineau R, Devergie A, Ribaud P, Esperou H, Gluckman E, Valla D, Socie G (2004) Long-term outcome of hepatitis C infection after bone marrow transplantation. Blood 103(5):1618–1624

    PubMed  CAS  Google Scholar 

  • Perkins JL, Kunin-Batson AS, Youngren NM, Ness KK, Ulrich KJ, Hansen MJ, Petryk A, Steinberger J, Anderson FS, Baker KS (2007) Long-term follow-up of children who underwent hematopoietic cell transplant (HCT) for AML or ALL at less than 3 years of age. Pediatr Blood Cancer 49(7):958–963. doi:10.1002/pbc.21207

    PubMed  Google Scholar 

  • Perrotta S, Conte ML, La Manna A, Indolfi P, Rossi F, Locatelli F, Nobili B (2005) Membranous glomerulopathy in children given allogeneic hematopoietic stem cell transplantation. Haematologica 90(Suppl):ECR31

    PubMed  Google Scholar 

  • Petryk A, Bergemann TL, Polga KM, Ulrich KJ, Raatz SK, Brown DM, Robison LL, Baker KS (2006) Prospective study of changes in bone mineral density and turnover in children after hematopoietic cell transplantation. J Clin Endocrinol Metab 91(3):899–905. doi:10.1210/jc.2005-1927, jc.2005-1927 [pii]

    PubMed  CAS  Google Scholar 

  • Phipps S, Dunavant M, Srivastava DK, Bowman L, Mulhern RK (2000) Cognitive and academic functioning in survivors of pediatric bone marrow transplantation. J Clin Oncol 18(5):1004–1011

    PubMed  CAS  Google Scholar 

  • Poppelreuter M, Weis J, Mumm A, Orth HB, Bartsch HH (2008) Rehabilitation of therapy-related cognitive deficits in patients after hematopoietic stem cell transplantation. Bone Marrow Transplant 41(1):79–90. doi:10.1038/sj.bmt.1705884, 1705884 [pii]

    PubMed  CAS  Google Scholar 

  • Prasad GV, Ahmed A, Nash MM, Zaltzman JS (2003) Blood pressure reduction with HMG-CoA reductase inhibitors in renal transplant recipients. Kidney Int 63(1):360–364

    PubMed  CAS  Google Scholar 

  • Prasad PK, Sun CL, Baker KS, Francisco L, Forman S, Bhatia S, Shankar SM (2008) Health care utilization by adult Hispanic long-term survivors of hematopoietic stem cell transplantation: report from the Bone Marrow Transplant Survivor Study. Cancer 113(10):2724–2733. doi:10.1002/cncr.23917

    PubMed  Google Scholar 

  • Pritchett JW (2001) Statin therapy decreases the risk of osteonecrosis in patients receiving steroids. Clin Orthop Relat Res 386:173–178

    PubMed  Google Scholar 

  • Probert JC, Parker BR (1975) The effects of radiation therapy on bone growth. Radiology 114(1):155–162

    PubMed  CAS  Google Scholar 

  • Pullarkat V, Blanchard S, Tegtmeier B, Dagis A, Patane K, Ito J, Forman SJ (2008) Iron overload adversely affects outcome of allogeneic hematopoietic cell transplantation. Bone Marrow Transplant 42(12): 799–805

    PubMed  CAS  Google Scholar 

  • Pulsipher MA, Skinner R, McDonald GB, Hingorani S, Armenian SH, Cooke KR, Gracia C, Petryk A, Bhatia S, Bunin N, Nieder ML, Dvorak CC, Sung L, Sanders JE, Kurtzberg J, Baker KS (2012) National Cancer Institute, National Heart, Lung and Blood Institute/Pediatric Blood and Marrow Transplantation Consortium First International Consensus Conference on Late Effects after Pediatric Hematopoietic Cell Transplantation: The Need for Pediatric-Specific Long-Term Follow-up Guidelines. Biol Blood Marrow Transplant 18(3):334–347. doi:10.1016/j.bbmt.2012.01.003, S1083-8791(12)00029-8 [pii]

    PubMed  Google Scholar 

  • Ramachandran M, Ward K, Brown RR, Munns CF, Cowell CT, Little DG (2007) Intravenous bisphosphonate therapy for traumatic osteonecrosis of the femoral head in adolescents. J Bone Joint Surg Am Vol 89(8):1727–1734

    Google Scholar 

  • Rao PS (2005) Nephrotic syndrome in patients with peripheral blood stem cell transplant. Am J Kidney Dis 45(4):780–785

    PubMed  Google Scholar 

  • Reddy P, Johnson K, Uberti JP, Reynolds C, Silver S, Ayash L, Braun TM, Ratanatharathorn V (2006) Nephrotic syndrome associated with chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant 38(5):351–357

    PubMed  CAS  Google Scholar 

  • Reusch JE (2002) Current concepts in insulin resistance, type 2 diabetes mellitus, and the metabolic syndrome. Am J Cardiol 90(5A):19G–26G

    PubMed  CAS  Google Scholar 

  • Rodgers C, Monroe R (2007) Osteopenia and osteoporosis in pediatric patients after stem cell transplant. J Pediatr Oncol Nurs 24(4):184–189. doi:10.1177/1043454207303942, 24/4/184 [pii]

    PubMed  Google Scholar 

  • Ron E, Lubin JH, Shore RE, Mabuchi K, Modan B, Pottern LM, Schneider AB, Tucker MA, Boice JD Jr (1995) Thyroid cancer after exposure to external radiation: a pooled analysis of seven studies. Radiat Res 141(3):259–277

    PubMed  CAS  Google Scholar 

  • Rose C, Ernst O, Hecquet B, Maboudou P, Renom P, Noel MP, Yakoub-Agha I, Bauters F, Jouet JP (2007) Quantification by magnetic resonance imaging and liver consequences of post-transfusional iron overload alone in long term survivors after allogeneic hematopoietic stem cell transplantation (HSCT). Haematologica 92(6):850–853

    PubMed  CAS  Google Scholar 

  • Rosenberg PS, Socie G, Alter BP, Gluckman E (2005) Risk of head and neck squamous cell cancer and death in patients with Fanconi anemia who did and did not receive transplants. Blood 105(1):67–73

    PubMed  CAS  Google Scholar 

  • Rourke M, Kazak A (2005) Psychological aspects of long-term survivorship. Survivors of childhood and adolescent cancer: a multidisciplinary approach, 2nd edn. Springer, Heidelberg

    Google Scholar 

  • Rovelli A, Cohen A, Uderzo C, Dodero P, Brisigotti M, Castellani MR, Romano C (1997) Follicular cell carcinoma of the thyroid in a child after bone marrow transplantation for acute lymphoblastic leukemia. Acta Haematol 97(4):225–227

    PubMed  CAS  Google Scholar 

  • Roy V, Rizvi MA, Vesely SK, George JN (2001) Thrombotic thrombocytopenic purpura-like syndromes following bone marrow transplantation: an analysis of associated conditions and clinical outcomes. Bone Marrow Transplant 27(6):641–646

    PubMed  CAS  Google Scholar 

  • Ruble K, Hayat MJ, Stewart KJ, Chen AR (2010) Bone mineral density after bone marrow transplantation in childhood: measurement and associations. Biol Blood Marrow Transplant 16(10):1451–1457. doi:10.1016/j.bbmt.2010.04.010, S1083-8791(10)00165-5 [pii]

    PubMed  Google Scholar 

  • Ruggenenti P, Noris M, Remuzzi G (2001) Thrombotic microangiopathy, hemolytic uremic syndrome, and thrombotic thrombocytopenic purpura. Kidney Int 60(3):831–846

    PubMed  CAS  Google Scholar 

  • Sakai M, Ikezoe T, Bandobashi K, Togitani K, Yokoyama A (2010) Successful treatment of transplantation-associated thrombotic microangiopathy with recombinant human soluble thrombomodulin. Bone Marrow Transplant 45(4):803–805

    PubMed  CAS  Google Scholar 

  • Salooja N, Szydlo RM, Socie G, Rio B, Chatterjee R, Ljungman P, Van Lint MT, Powles R, Jackson G, Hinterberger-Fischer M, Kolb HJ, Apperley JF (2001) Pregnancy outcomes after peripheral blood or bone marrow transplantation: a retrospective survey. Lancet 358(9278):271–276, S0140673601054824 [pii]

    PubMed  CAS  Google Scholar 

  • Sanders JE (1991) Endocrine problems in children after bone marrow transplant for hematologic malignancies. The Long-term follow-up team. Bone Marrow Transplant 8(Suppl 1):2–4

    PubMed  Google Scholar 

  • Sanders JE (2008) Growth and development after hematopoietic cell transplant in children. Bone Marrow Transplant 41(2):223–227. doi:10.1038/sj.bmt.1705875, 1705875 [pii]

    PubMed  CAS  Google Scholar 

  • Sanders JE, Flournoy N, Thomas ED, Buckner CD, Lum LG, Clift RA, Appelbaum FR, Sullivan KM, Stewart P, Deeg HJ et al (1985) Marrow transplant experience in children with acute lymphoblastic leukemia: an analysis of factors associated with survival, relapse, and graft-versus-host disease. Med Pediatr Oncol 13(4):165–172

    PubMed  CAS  Google Scholar 

  • Sanders JE, Pritchard S, Mahoney P, Amos D, Buckner CD, Witherspoon RP, Deeg HJ, Doney KC, Sullivan KM, Appelbaum FR et al (1986) Growth and development following marrow transplantation for leukemia. Blood 68(5):1129–1135

    PubMed  CAS  Google Scholar 

  • Sanders JE, Buckner CD, Amos D, Levy W, Appelbaum FR, Doney K, Storb R, Sullivan KM, Witherspoon RP, Thomas ED (1988) Ovarian function following marrow transplantation for aplastic anemia or leukemia. J Clin Oncol 6(5):813–818

    PubMed  CAS  Google Scholar 

  • Sanders JE, Hawley J, Levy W, Gooley T, Buckner CD, Deeg HJ, Doney K, Storb R, Sullivan K, Witherspoon R, Appelbaum FR (1996) Pregnancies following high-dose cyclophosphamide with or without high-dose busulfan or total-body irradiation and bone marrow transplantation. Blood 87(7):3045–3052

    PubMed  CAS  Google Scholar 

  • Sanders JE, Guthrie KA, Hoffmeister PA, Woolfrey AE, Carpenter PA, Appelbaum FR (2005) Final adult height of patients who received hematopoietic cell transplantation in childhood. Blood 105(3):1348–1354. doi:10.1182/blood-2004-07-2528, 2004-07-2528 [pii]

    PubMed  CAS  Google Scholar 

  • Sanders JE, Hoffmeister PA, Woolfrey AE, Carpenter PA, Storer BE, Storb RF, Appelbaum FR (2009) Thyroid function following hematopoietic cell transplantation in children: 30 years' experience. Blood 113(2):306–308. doi:10.1182/blood-2008-08-173005, blood-2008-08-173005 [pii]

    PubMed  CAS  Google Scholar 

  • Sanders JE, Woolfrey AE, Carpenter PA, Storer BE, Hoffmeister PA, Deeg HJ, Flowers ME, Storb RF (2011) Late effects among pediatric patients followed for nearly 4 decades after transplantation for severe aplastic anemia. Blood 118(5):1421–1428. doi:10.1182/blood-2011-02-334953, blood-2011-02-334953 [pii]

    PubMed  CAS  Google Scholar 

  • Sarkodee-Adoo C, Sotirescu D, Sensenbrenner L, Rapoport AP, Cottler-Fox M, Tricot G, Ruehle K, Meisenberg B (2003) Thrombotic microangiopathy in blood and marrow transplant patients receiving tacrolimus or cyclosporine A. Transfusion 43(1):78–84

    PubMed  CAS  Google Scholar 

  • Sauleda J, Gea JG, Aguar MC, Aran X, Pasto M, Broquetas JM (1994) Probable pentamidine-induced acute pancreatitis. Ann Pharmacother 28(1):52–53

    PubMed  CAS  Google Scholar 

  • Schimmer AD, Minden MD, Keating A (2000) Osteoporosis after blood and marrow transplantation: clinical aspects. Biol Blood Marrow Transplant 6(2A):175–181

    PubMed  CAS  Google Scholar 

  • Schulte CM, Beelen DW (2004) Bone loss following hematopoietic stem cell transplantation: a long-term follow-up. Blood 103(10):3635–3643

    PubMed  CAS  Google Scholar 

  • Sebastian E, Martin J, McDonald GB, Flores T, Rodriguez A, Blanco A, Vazquez L, de Fuentes I, Caballero MD (2011) Cryptosporidium parvum infection vs GVHD after hematopoietic SCT: diagnosis by PCR with resolution of symptoms. Bone Marrow Transplant 46(4):612–614

    PubMed  CAS  Google Scholar 

  • Shah AJ, Epport K, Azen C, Killen R, Wilson K, De Clerck D, Crooks G, Kapoor N, Kohn DB, Parkman R, Weinberg KI (2008) Progressive declines in neurocognitive function among survivors of hematopoietic stem cell transplantation for pediatric hematologic malignancies. J Pediatr Hematol Oncol 30(6):411–418. doi:10.1097/MPH.0b013e318168e750

    PubMed  Google Scholar 

  • Shalet SM, Gibson B, Swindell R, Pearson D (1987) Effect of spinal irradiation on growth. Arch Dis Childhood 62(5):461–464

    CAS  Google Scholar 

  • Shalitin S, Phillip M, Stein J, Goshen Y, Carmi D, Yaniv I (2006) Endocrine dysfunction and parameters of the metabolic syndrome after bone marrow transplantation during childhood and adolescence. Bone Marrow Transplant 37(12):1109–1117. doi:10.1038/sj.bmt.1705374, 1705374 [pii]

    PubMed  CAS  Google Scholar 

  • Shankar SM, Bunin NJ, Moshang T Jr (1996) Growth in children undergoing bone marrow transplantation after busulfan and cyclophosphamide conditioning. J Pediatr Hematol Oncol 18(4):362–366

    PubMed  CAS  Google Scholar 

  • Shepherd J, Cobbe SM, Ford I, Isles CG, Lorimer AR, Macfarlane PW, McKillop JH, Packard CJ (1995) Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. New Engl J Med 333(20):1301–1307

    PubMed  CAS  Google Scholar 

  • Shepherd J, Blauw GJ, Murphy MB, Bollen EL, Buckley BM, Cobbe SM, Ford I, Gaw A, Hyland M, Jukema JW, Kamper AM, Macfarlane PW, Meinders AE, Norrie J, Packard CJ, Perry IJ, Stott DJ, Sweeney BJ, Twomey C, Westendorp RG, PsgPSoPitEa R (2002) Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial. Lancet 360(9346):1623–1630

    PubMed  CAS  Google Scholar 

  • Shore RE, Woodard E, Hildreth N, Dvoretsky P, Hempelmann L, Pasternack B (1985) Thyroid tumors following thymus irradiation. J Natl Cancer Inst 74(6):1177–1184

    PubMed  CAS  Google Scholar 

  • Sklar C, Sarafoglou K, Whittam E (1993) Efficacy of insulin-like growth factor binding protein 3 in predicting the growth hormone response to provocative testing in children treated with cranial irradiation. Acta Endocrinol (Copenh) 129(6):511–515

    CAS  Google Scholar 

  • Sklar C, Boulad F, Small T, Kernan N (2001) Endocrine complications of pediatric stem cell transplantation. Front Biosci 6:G17–G22

    PubMed  CAS  Google Scholar 

  • Slatter MA, Gennery AR, Cheetham TD, Bhattacharya A, Crooks BN, Flood TJ, Cant AJ, Abinun M (2004) Thyroid dysfunction after bone marrow transplantation for primary immunodeficiency without the use of total body irradiation in conditioning. Bone Marrow Transplant 33(9):949–953. doi:10.1038/sj.bmt.1704456, 1704456 [pii]

    PubMed  CAS  Google Scholar 

  • Snover DC, Weisdorf S, Bloomer J, McGlave P, Weisdorf D (1989) Nodular regenerative hyperplasia of the liver following bone marrow transplantation. Hepatology 9(3):443–448

    PubMed  CAS  Google Scholar 

  • Socie G, Curtis RE, Deeg HJ, Sobocinski KA, Filipovich AH, Travis LB, Sullivan KM, Rowlings PA, Kingma DW, Banks PM, Travis WD, Witherspoon RP, Sanders J, Jaffe ES, Horowitz MM (2000) New malignant diseases after allogeneic marrow transplantation for childhood acute leukemia. J Clin Oncol 18(2):348–357

    PubMed  CAS  Google Scholar 

  • Som S, Deford CC, Kaiser ML, Terrell DR, Kremer Hovinga JA, Lammle B, George JN, Vesely SK (2012) Decreasing frequency of plasma exchange complications in patients treated for thrombotic thrombocytopenic purpura-hemolytic uremic syndrome, 1996 to 2011. Transfusion 52(12):2525–2532

    PubMed  Google Scholar 

  • Spinelli S, Chiodi S, Bacigalupo A, Brasca A, Menada MV, Petti AR, Ravera G, Gualandi F, VanLint MT, Sessarego M et al (1994) Ovarian recovery after total body irradiation and allogeneic bone marrow transplantation: long-term follow up of 79 females. Bone Marrow Transplant 14(3):373–380

    PubMed  CAS  Google Scholar 

  • Stern JM, Sullivan KM, Ott SM, Seidel K, Fink JC, Longton G, Sherrard DJ (2001) Bone density loss after allogeneic hematopoietic stem cell transplantation: a prospective study. Biol Blood Marrow Transplant 7(5):257–264

    PubMed  CAS  Google Scholar 

  • Stevens AM, Sullivan KM, Nelson JL (2003) Polymyositis as a manifestation of chronic graft-versus-host disease (Review). Rheumatology 42(1):34–39

    PubMed  CAS  Google Scholar 

  • Stewart BL, Storer B, Storek J, Deeg HJ, Storb R, Hansen JA, Appelbaum FR, Carpenter PA, Sanders JE, Kiem HP, Nash RA, Petersdorf EW, Moravec C, Morton AJ, Anasetti C, Flowers MED, Martin PJ (2004) Duration of immunosuppressive treatment for chronic graft-versus-host disease. Blood 104(12):3501–3506

    PubMed  CAS  Google Scholar 

  • Strasser SI, Myerson D, Spurgeon CL, Sullivan KM, Storer B, Schoch HG, Kim S, Flowers ME, McDonald GB (1999a) Hepatitis C virus infection and bone marrow transplantation: a cohort study with 10-year follow-up. Hepatology 29(6):1893–1899

    PubMed  CAS  Google Scholar 

  • Strasser SI, Sullivan KM, Myerson D, Spurgeon CL, Storer B, Schoch HG, Murakami CS, McDonald GB (1999b) Cirrhosis of the liver in long-term marrow transplant survivors. Blood 93(10):3259–3266

    PubMed  CAS  Google Scholar 

  • Strippoli GF, Craig M, Deeks JJ, Schena FP, Craig JC (2004) Effects of angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists on mortality and renal outcomes in diabetic nephropathy: systematic review (Review). BMJ 329(7470):828

    PubMed  CAS  Google Scholar 

  • Stulberg BN, Davis AW, Bauer TW, Levine M, Easley K (1991) Osteonecrosis of the femoral head. A prospective randomized treatment protocol. Clin Orthop Relat Res 268:140–151

    PubMed  Google Scholar 

  • Sudour H, Mainard L, Baumann C, Clement L, Salmon A, Bordigoni P (2009) Focal nodular hyperplasia of the liver following hematopoietic SCT. Bone Marrow Transplant 43(2):127–132

    PubMed  CAS  Google Scholar 

  • Suehiro T, Masutani K, Yokoyama M, Tokumoto M, Tsuruya K, Fukuda K, Kanai H, Katafuchi R, Nagatoshi Y, Hirakata H (2002) Diffuse proliferative glomerulonephritis after bone marrow transplantation. Clin Nephrol 58(3):231–237

    PubMed  CAS  Google Scholar 

  • Suh DW, Ruttum MS, Stuckenschneider BJ, Mieler WF, Kivlin JD (1999) Ocular findings after bone marrow transplantation in a pediatric population. Ophthalmology 106(8):1564–1570

    PubMed  CAS  Google Scholar 

  • Syrjala KL, Langer SL, Abrams JR, Storer B, Sanders JE, Flowers ME, Martin PJ (2004) Recovery and long-term function after hematopoietic cell transplantation for leukemia or lymphoma. JAMA 291(19):2335–2343. doi:10.1001/jama.291.19.2335, 291/19/2335 [pii]

    PubMed  CAS  Google Scholar 

  • Talvensaari K, Knip M (1997) Childhood cancer and later development of the metabolic syndrome. Ann Med 29(5):353–355

    PubMed  CAS  Google Scholar 

  • Talvensaari KK, Lanning M, Tapanainen P, Knip M (1996) Long-term survivors of childhood cancer have an increased risk of manifesting the metabolic syndrome. J Clin Endocrinol Metab 81(8):3051–3055

    PubMed  CAS  Google Scholar 

  • Tarbell NJ, Guinan EC, Chin L, Mauch P, Weinstein HJ (1990) Renal insufficiency after total body irradiation for pediatric bone marrow transplantation. Radiother Oncol 18(Suppl 1):139–142

    PubMed  Google Scholar 

  • Taskinen M, Saarinen-Pihkala UM, Hovi L, Lipsanen-Nyman M (2000) Impaired glucose tolerance and dyslipidaemia as late effects after bone- marrow transplantation in childhood. Lancet 356(9234):993–997

    PubMed  CAS  Google Scholar 

  • Taskinen M, Kananen K, Valimaki M, Loyttyniemi E, Hovi L, Saarinen-Pihkala U, Lipsanen-Nyman M (2006) Risk factors for reduced areal bone mineral density in young adults with stem cell transplantation in childhood. Pediatr Transplant 10(1):90–97. doi:10.1111/j.1399-3046.2005.00405.x, PTR405 [pii]

    PubMed  CAS  Google Scholar 

  • Taskinen M, Saarinen-Pihkala UM, Hovi L, Vettenranta K, Makitie O (2007) Bone health in children and adolescents after allogeneic stem cell transplantation: high prevalence of vertebral compression fractures. Cancer 110(2):442–451. doi:10.1002/cncr.22796

    PubMed  Google Scholar 

  • Tatevossian R, Blair JC, Plowman PN, Savage MO, Shankar AG (2004) Thyrotoxicosis after matched unrelated bone marrow transplantation. J Pediatr Hematol Oncol 26(8):529–531

    PubMed  Google Scholar 

  • Thibaud E, Rodriguez-Macias K, Trivin C, Esperou H, Michon J, Brauner R (1998) Ovarian function after bone marrow transplantation during childhood. Bone Marrow Transplant 21(3):287–290. doi:10.1038/sj.bmt.1701075

    PubMed  CAS  Google Scholar 

  • Thomas BC, Stanhope R, Plowman PN, Leiper AD (1993a) Endocrine function following single fraction and fractionated total body irradiation for bone marrow transplantation in childhood. Acta Endocrinol (Copenh) 128(6):508–512

    CAS  Google Scholar 

  • Thomas BC, Stanhope R, Plowman PN, Leiper AD (1993b) Growth following single fraction and fractionated total body irradiation for bone marrow transplantation. Eur J Pediatr 152(11):888–892

    PubMed  CAS  Google Scholar 

  • Thomas SE, Hutchinson RJ, DebRoy M, Magee JC (2004) Successful renal transplantation following prior bone marrow transplantation in pediatric patients. Pediatr Transplant 8(5):507–512

    PubMed  Google Scholar 

  • Tofferi JK, Gilliland W (2006) Avascular necrosis. WebMD: http://www.emedicine.com/med/topic2924.htm

  • Tolar J, Petryk A, Khan K, Bjoraker KJ, Jessurun J, Dolan M, Kivisto T, Charnas L, Shapiro EG, Orchard PJ (2009) Long-term metabolic, endocrine, and neuropsychological outcome of hematopoietic cell transplantation for Wolman disease. Bone Marrow Transplant 43(1):21–27. doi:10.1038/bmt.2008.273

    PubMed  CAS  Google Scholar 

  • Tomonari A, Takahashi S, Takasugi K, Ooi J, Tsukada N, Konuma T, Iseki T, Tojo A, Asano S (2006) Pancreatic hyperamylasemia and hyperlipasemia in association with cytomegalovirus infection following unrelated cord blood transplantation for acute myelogenous leukemia. Int J Hematol 84(5):438–440

    PubMed  CAS  Google Scholar 

  • Treister NS, Woo SB, O'Holleran EW, Lehmann LE, Parsons SK, Guinan EC (2005) Oral chronic graft-versus-host disease in pediatric patients after hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 11(9):721–731

    PubMed  Google Scholar 

  • Treister NS, Cook EF Jr, Antin J, Lee SJ, Soiffer R, Woo SB (2008) Clinical evaluation of oral chronic graft-versus-host disease. Biol Blood Marrow Transplant 14(1):110–115

    PubMed  Google Scholar 

  • Trevisan M, Liu J, Bahsas FB, Menotti A (1998) Syndrome X and mortality: a population-based study. Risk Factor and Life Expectancy Research Group. Am J Epidemiol 148(10):958–966

    PubMed  CAS  Google Scholar 

  • Tsiara S, Elisaf M, Mikhailidis DP (2003) Early vascular benefits of statin therapy (Review). Curr Med Res Opin 19(6):540–556

    PubMed  CAS  Google Scholar 

  • Uderzo C, van Lint MT, Rovelli A, Weber G, Castellani MR, Bacigalupo A, Masera N, Cohen A (1994) Papillary thyroid carcinoma after total body irradiation. Arch Dis Childhood 71(3):256–258

    CAS  Google Scholar 

  • Uderzo C, Fraschini D, Balduzzi A, Galimberti S, Arrigo C, Biagi E, Pignanelli M, Nicolini B, Rovelli A (1997) Long-term effects of bone marrow transplantation on dental status in children with leukaemia. Bone Marrow Transplant 20(10):865–869

    PubMed  CAS  Google Scholar 

  • Uderzo C, Fumagalli M, De Lorenzo P, Busca A, Vassallo E, Bonanomi S, Lanino E, Dini G, Varotto S, Messina C, Miniero R, Valsecchi MG, Balduzzi A (2000) Impact of thrombotic thrombocytopenic purpura on leukemic children undergoing bone marrow transplantation. Bone Marrow Transplant 26(9):1005–1009

    PubMed  CAS  Google Scholar 

  • Valimaki MJ, Kinnunen K, Volin L, Tahtela R, Loyttyniemi E, Laitinen K, Makela P, Keto P, Ruutu T (1999) A prospective study of bone loss and turnover after allogeneic bone marrow transplantation: effect of calcium supplementation with or without calcitonin. Bone Marrow Transplant 23(4):355–361

    PubMed  CAS  Google Scholar 

  • van Burik JA, Lawatsch EJ, DeFor TE, Weisdorf DJ (2001) Cytomegalovirus enteritis among hematopoietic stem cell transplant recipients. Biol Blood Marrow Transplant 7(12):674–679

    PubMed  Google Scholar 

  • van Burik JA, Carter SL, Freifeld AG, High KP, Godder KT, Papanicolaou GA, Mendizabal AM, Wagner JE, Yanovich S, Kernan NA (2007) Higher risk of cytomegalovirus and aspergillus infections in recipients of T cell-depleted unrelated bone marrow: analysis of infectious complications in patients treated with T cell depletion versus immunosuppressive therapy to prevent graft-versus-host disease. Biol Blood Marrow Transplant 13(12):1487–1498. doi:10.1016/j.bbmt.2007.08.049, S1083-8791(07)00440-5 [pii]

    PubMed  Google Scholar 

  • van der Pas-van Voskuilen IG, Veerkamp JS, Raber-Durlacher JE, Bresters D, van Wijk AJ, Barasch A, McNeal S, Gortzak RA (2009) Long-term adverse effects of hematopoietic stem cell transplantation on dental development in children. Support Care Cancer 17(9):1169–1175

    PubMed  Google Scholar 

  • van Kempen-Harteveld ML, Struikmans H, Kal HB, van der Tweel I, Mourits MP, Verdonck LF, Schipper J, Battermann JJ (2000) Cataract-free interval and severity of cataract after total body irradiation and bone marrow transplantation: influence of treatment parameters. Int J Radiat Oncol Biol Phys 48(3):807–815

    PubMed  Google Scholar 

  • Van Why SK, Friedman AL, Wei LJ, Hong R (1991) Renal insufficiency after bone marrow transplantation in children. Bone Marrow Transplant 7(5):383–388

    PubMed  Google Scholar 

  • Vassal G, Deroussent A, Hartmann O, Challine D, Benhamou E, Valteau-Couanet D, Brugieres L, Kalifa C, Gouyette A, Lemerle J (1990) Dose-dependent neurotoxicity of high-dose busulfan in children: a clinical and pharmacological study. Cancer Res 50(19):6203–6207

    PubMed  CAS  Google Scholar 

  • Versleijen MW, Naber AH, Riksen NP, Wanten GJ, Debruyne FM (2005) Recurrent pancreatitis after trimethoprim-sulfamethoxazole rechallenge. Neth J Med 63(7):275–277

    PubMed  CAS  Google Scholar 

  • Vincent F, Costa MA, Rondeau E (2003) Chronic renal failure: a nonmalignant late effect of allogeneic stem cell transplantation (Letter to the Editor). Blood 102(7):2695–2696

    PubMed  CAS  Google Scholar 

  • Wang GJ, Cui Q, Balian G (2000) The Nicolas Andry award. The pathogenesis and prevention of steroid-induced osteonecrosis. Clin Orthop Relat Res 370:295–310

    PubMed  Google Scholar 

  • Ward LM, Petryk A, Gordon CM (2009) Use of bisphosphonates in the treatment of pediatric osteoporosis. Int J Clin Rheumatol 4(6):657–672

    CAS  Google Scholar 

  • Wasilewski-Masker K, Kaste SC, Hudson MM, Esiashvili N, Mattano LA, Meacham LR (2008) Bone mineral density deficits in survivors of childhood cancer: long-term follow-up guidelines and review of the literature. Pediatrics 121(3):e705–e713. doi:10.1542/peds.2007-1396, 121/3/e705 [pii]

    PubMed  Google Scholar 

  • Weilbaecher KN (2000) Mechanisms of osteoporosis after hematopoietic cell transplantation. Biol Blood Marrow Transplant 6(2A):165–174

    PubMed  CAS  Google Scholar 

  • Wingard JR, Plotnick LP, Freemer CS, Zahurak M, Piantadosi S, Miller DF, Vriesendorp HM, Yeager AM, Santos GW (1992) Growth in children after bone marrow transplantation: busulfan plus cyclophosphamide versus cyclophosphamide plus total body irradiation. Blood 79(4):1068–1073

    PubMed  CAS  Google Scholar 

  • Wood JC, Enriquez C, Ghugre N, Tyzka JM, Carson S, Nelson MD, Coates TD (2005) MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients. Blood 106(4):1460–1465

    PubMed  CAS  Google Scholar 

  • World Health Organization (1994) Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study Group. World Health Organ Tech Rep Ser 843:1–129

    Google Scholar 

  • Yokota A, Ozawa S, Masanori T, Akiyama H, Ohshima K, Kanda Y, Takahashi S, Mori T, Nakaseko C, Onoda M, Kishi K, Doki N, Aotsuka N, Kanamori H, Maruta A, Sakamaki H, Okamoto S (2012) Secondary solid tumors after allogeneic hematopoietic SCT in Japan. Bone Marrow Transplant 47(1):95–100

    PubMed  CAS  Google Scholar 

  • Zou S, Stramer SL, Dodd RY (2012) Donor testing and risk: current prevalence, incidence, and residual risk of transfusion-transmissible agents in US allogeneic donations. Transfus Med Rev 26(2):119–128

    PubMed  Google Scholar 

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Baker, K.S., Petryk, A., Fisher, V.L., Duncan, C., Carpenter, P.A. (2014). Late Effects in Survivors After Hematopoietic Cell Transplantation in Childhood. In: Smith, F., Reaman, G., Racadio, J. (eds) Hematopoietic Cell Transplantation in Children with Cancer. Pediatric Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-39920-6_7

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