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The History of Pediatric Hematopoietic Cell Transplantation Around the World

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Hematopoietic Cell Transplantation in Children with Cancer

Part of the book series: Pediatric Oncology ((PEDIATRICO))

Abstract

The concept of modern-day hematopoietic cell transplantation began in the 1950s with mouse studies demonstrating that the irradiated mouse would survive if the spleen was shielded and that the mouse could be protected by an infusion of spleen or marrow cells collected prior to irradiation. Early attempts at human marrow transplant failed except in syngeneic situations, but a few successful transplants in young patients with resistant leukemia demonstrated that lethal total body irradiation followed by infusion of compatible marrow could lead to restoration of marrow function and control of the leukemia. The development of pediatric transplantation in the United States and Canada, Europe, South and Latin America, Australia, and China is described in this chapter. A reasonable estimate is that approximately 88,546 children <18 years of age have received hematopoietic cell transplant around the world through 2010.

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Authors and Affiliations

  1. Member Emeritus Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, USA

    Jean E. Sanders MD (Professor Emeritus Pediatrics)

  2. University of Nebraska Medical Center, Omaha, Nebraska, USA

    Peter F. Coccia MD (Ittner Professor and Vice Chair Pediatrics)

  3. Department of Pediatrics, University of Tubingen, Tubingen, Germany

    Dietrich Niethammer MD (Professor of Pediatrics Emeritus)

  4. Clinical Hospital, Federal University of Parana, Curitiba, Brazil

    Carmemm M. Bonfim MD (Director Pediatric Blood and Marrow Transplant Program)

  5. Head BMT Service, Oncology Unit, Children’s Hospital at Westmead, Clinical Professor Pediatrics and Child Health, University of Sydney Medical Program, Sydney, NSW, Australia

    Peter J. Shaw MA

  6. Chinese University of Hong Kong, Coordinating Committee in Paediatrics Hospital Authority Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong

    Chi-Kong Li MBBS, MD (Chairman)

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  1. Jean E. Sanders MD
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  2. Peter F. Coccia MD
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  3. Dietrich Niethammer MD
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  4. Carmemm M. Bonfim MD
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  5. Peter J. Shaw MA
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  6. Chi-Kong Li MBBS, MD
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Corresponding author

Correspondence to Jean E. Sanders MD .

Editor information

Editors and Affiliations

  1. University of Cincinnati, Cincinnati, Ohio, USA

    Franklin O. Smith

  2. George Washington University, Washington, Washington, USA

    Gregory H. Reaman

  3. Division of Hematology/Oncology, Dept. of Internal Medicine, University of Cincinnati College of Medicine, Madeira, Ohio, USA

    Judy M. Racadio

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Sanders, J.E., Coccia, P.F., Niethammer, D., Bonfim, C.M., Shaw, P.J., Li, CK. (2014). The History of Pediatric Hematopoietic Cell Transplantation Around the World. In: Smith, F., Reaman, G., Racadio, J. (eds) Hematopoietic Cell Transplantation in Children with Cancer. Pediatric Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-39920-6_1

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  • DOI: https://doi.org/10.1007/978-3-642-39920-6_1

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