Abstract
Photodynamic therapy with full spectrum visible light and porphyrin-type photosensitisers appears to efficiently induce the inactivation of a broad spectrum of microbial pathogens, including antibiotic-resistant strains, without in turn promoting the selection of PDT-resistant species. Application of this therapeutic modality to the treatment of spontaneously developed infections in dogs resulted in a very efficient healing of wounds with an extensive drop in the population of pathogens. The treatment appeared to be applicable for both mycotic and bacterial infections and was devoid of detectable undesired side effects. No significant differences in efficacy was observed whether a porphyrin, chlorin, or phthalocyanine photosensitising agent was used in spite of strong differences in the light absorption spectrum among the three tetrapyrrole derivatives.
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References
Brown SB, Brown EA, Walker I (2004) The present and future role of photodynamic therapy in cancer treatment. Lancet Oncol 5:497–508
Ochsner M (1997) Photophysical and photobiological processes in the photodynamic therapy of tumours. J Photochem Photobiol B: Biol 39:1–18
Moan J, Peng Q (2003) An outline of the hundred-year history of PDT. Anticancer Res 23:3591–3600
Jori G, Spikes JD (1994) Photobiochemistry of porphyrins. In: Smith KC (ed) Topics in photomedicine. Plenum Press, New York, pp 183–319
Jori G, Fabris C, Soncin M et al (2006) Photodynamic therapy in the treatment of microbial infections: basic principles and perspective applications. Lasers Surg Med 38:468–481
Maisch T (2007) Anti-microbial photodynamic therapy: useful in the future? Lasers Med Sci 22:83–91
Huang L, Dai T, Hamblin MR (2010) Antimicrobial photodynamic inactivation and photodynamic therapy for infections. Methods Mol Biol 635:155–173
Jori G, Brown SB (2004) Photosensitised inactivation of micro-organisms. Photochem Photobiol Sci 3:403–407
Wainwright M (2004) Photoantimicrobials—a PACT against resistance and infection. Drug Future 29:85–93
Hamblin MR, Hasan T (2004) Photodynamic therapy: a new antimicrobial approach to infectious disease. Photochem Photobiol Sci 3:436–450
Soncin M, Fabris C, Busetti A et al (2002) Approaches to selectivity in the Zn(II)-phthalocyanine-photosensitised inactivation of wild-type and antibiotic-resistant Staphylococcus aureus. Photochem Photobiol Sci 1:815–819
Jori G, Coppellotti O (2007) Inactivation of pathogenic microorganisms by photodynamic techniques: mechanistic aspects and perspective applications. Anti-infective Agents Med Chem 6:119–131
Maisch T (2009) A new strategy to destroy antibiotic-resistant micro-organisms: antimicrobial photodynamic therapy. Mini-review Med Chem 9:947–983
Dai T, Huang YY, Hamblin MR (2009) Photodynamic therapy for localized infections—state of the art. Photodiagn Photodyn Ther 6:170–188
Redmond RW, Gamlin JN (1999) A compilation of singlet oxygen yields from biologically relevant molecules. Photochem Photobiol 70:391–475
Conway C, Brown SB (2012) Photodynamic therapy. In: Griesbeck A, Oelgemoeller M, Ghetti F (eds) CRC handbook of organic photochemistry and photobiology, vol 2, 3rd edn. CRC Press, Boca Raton, pp 1511–1528
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Fabris, C. et al. (2014). Photodynamic Therapy: A Novel Promising Approach for the Treatment of Spontaneous Microbial Infections in Pet Animals. In: Abdel-Kader, M. (eds) Photodynamic Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-39629-8_12
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DOI: https://doi.org/10.1007/978-3-642-39629-8_12
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