Abstract
Skin lesion analysis using standard camera images has received limited attention from the scientific community due to its technical complexity and scarcity of data. The images are privy to lighting variations caused by uneven source lighting, and unconstrained differences in resolution, scale, and equipment. In this chapter, we propose a framework that performs illumination correction and feature extraction on photographs of skin lesions acquired using standard consumer-grade cameras. We apply a multi-stage illumination correction algorithm and define a set of high-level intuitive features (HLIF) that quantifies the level of asymmetry and border irregularity about a lesion. This lighting-corrected intuitive feature model framework can be used to classify skin lesion diagnoses with high accuracy. The framework accurately corrects the illumination variations and achieves high and precise sensitivity (95 % confidence interval (CI), 73.1–73.5 %) and specificity (95 % CI, 72.0–72.4 %) using a linear support vector machine classifier with cross-validation trials. It exhibits higher test-retest reliability than the much larger state-of-the-art low-level feature set (95 % CI, 78.1–79.7 % sensitivity, 75.3–76.3 % specificity). Combining our framework with these low-level features attains sensitivity (95 % CI, 83.3–84.8 %) and specificity (95 % CI, 79.7–80.1 %), which is more accurate and reliable than classification using the low-level feature set.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Alcon, J.F., Ciuhu, C., Ten Kate, W., Heinrich, A., Uzunbajakava, N., Krekels, G., Siem, D., de Haan, G.: Automatic imaging system with decision support for inspection of pigmented skin lesions and melanoma diagnosis. IEEE J. Sel. Top. Signal Proces. 3(1), 14–25 (2009)
Aldridge, R.B., Glodzik, D., Ballerini, L., Fisher, R.B.: Utility of non-rule-based visual matching as a strategy to allow novices to achieve skin lesion diagnosis. Acta Derm. Venereol. 91(3), 279–283 (2011)
Amelard, R., Wong, A., Clausi, D.A.: Extracting high-level intuitive features (HLIF) for classifying skin lesions using standard camera images. In: CRV’12: Ninth Conference on Computer and Robot Vision, Toronto, pp. 396–403 (2012a)
Amelard, R., Wong, A., Clausi, D.A.: Extracting morphological high-level intuitive features (HLIF) for enhancing skin lesion classification. In: EMBC’12: 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, San Diego, pp. 4458–4461 (2012b)
Argenziano, G., Soyer, H.P., Chimenti, S., Talamini, R., Corona, R., Sera, F., Binder, M., Cerroni, L., De Rosa, G., Ferrara, G.: Dermoscopy of pigmented skin lesions: results of a consensus meeting via the internet. J. Am. Acad. Dermatol. 48(5), 679–693 (2003)
Aribisala, B.S., Claridge, E.: A border irregularity measure using a modified conditional entropy method as a malignant melanoma predictor. In: Kamel, M., Campilho, A. (eds.) Image Analysis and Recognition, Lecture Notes in Computer Science, vol. 3656. Springer, Heidelberg, pp. 914–921 (2005)
Ballerini, L., Li, X., Fisher, R.B., Rees, J.: A query-by-example content-based image retrieval system of non-melanoma skin lesions. In: Caputo, B., Müller, H., Syeda-Mahmood, T., Duncan, J., Wang, F., Kalpathy-Cramer, J. (eds.) Medical Content-Based Retrieval for Clinical Decision Support, Lecture Notes in Computer Science, vol. 5853, pp. 31–38. Springer, Heidelberg (2010)
Ballerini, L., Fisher, R.B., Aldridge, B., Rees, J.: A color and texture based hierarchical K-NN approach to the classification of non-melanoma skin lesions. In: Celebi, M.E., Schaefer, G. (eds.) Color Medical Image Analysis, Lecture Notes in Computational Vision and Biomechanics, vol. 6, pp 63–86. Springer, Netherlands (2013)
Cavalcanti, P.G., Scharcanski, J.: Automated prescreening of pigmented skin lesions using standard cameras. Comput. Med. Imaging Graph. 35(6), 481–491 (2011)
Cavalcanti, P.G.., Scharcanski, J., Lopes, C.B.O.: Shading attenuation in human skin color images. In: Bebis, G., Boyle, R., Parvin, B., Koracin, D., Chung, R., Hammoud, R., Hussain, M., Kar-Han, T., Crawfis, R., Thalmann, D., Kao, D., Avila, L. (eds.) Advances in Visual Computing, Lecture Notes in Computer Science, vol. 6453, pp. 190–198. Springer, Heidelberg (2010)
Celebi, M.E., Aslandogan, Y.A.: Content-based image retrieval incorporating models of human perception. In: ITCC’04: International Conference on Information Technology: Coding and Computing, vol. 2, pp. 241–245 Las Vegas (2004)
Celebi, M.E., Kingravi, H.A., Uddin, B., Iyatomi, H., Aslandogan, Y.A., Stoecker, W.V., Moss, R.H.: A methodological approach to the classification of dermoscopy images. Comput. Med. Imaging Graph. 31(6), 362–373 (2007)
Celebi, M.E., Iyatomi, H., Schaefer, G.: Contrast enhancement in dermoscopy images by maximizing a histogram bimodality measure. In: ICIP’09: 16th IEEE International Conference on Image Processing, Cairo, pp 2601–2604 (2009)
Chang, C.C., Lin, C.J.: Libsvm: A library for support vector machines. ACM Trans. Intel. Syst. Technol.2(3), 27:1–27:27 (2011). http://www.csie.ntu.edu.tw/ cjlin/libsvm
Chen, M.H.: Importance-weighted marginal bayesian posterior density estimation. J. Am. Stat. Assoc. 89(427), 818–824 (1994)
Chen, T., Yin, W., Zhou, X.S., Comaniciu, D., Huang, T.S.: Pattern Anal. Mach. Intel. IEEE Trans. 28(9), 1519–1524 (2006)
Claridge, E., Cotton, S., Hall, P., Moncrieff, M.: From colour to tissue histology: physics-based interpretation of images of pigmented skin lesions. Med. Image Anal. 7(4), 489–502 (2003)
Cortes, C., Vapnik, V.: Support-vector networks. Mach. Learn. 20, 273–297 (1995)
Cotton, S.D.: A non-invasive imaging system for assisting in the diagnosis of malignant melanoma. PhD thesis, University of Birmingham, UK (1998)
D’Alessandro, B., Dhawan, A.P.: 3-d volume reconstruction of skin lesions for melanin and blood volume estimation and lesion severity analysis. IEEE Trans. Med. Imaging 31(11), 2083–2092 (2012)
Day, G.R., Barbour, R.H.: Automated melanoma diagnosis: where are we at? Skin Res. Technol. 6(1), 1–5 (2000)
Dermatology Information System: (2012). http://www.dermis.net. Accessed 08 Nov 2012
DermQuest: (2012). http://www.dermquest.com. Accessed 08 Nov 2012
Elad, M.: Retinex by two bilateral filters. In: Kimmel, R., Sochen, N.A., Weickert, J. (eds.) Scale Space and PDE Methods in Computer Vision, Lecture Notes in Computer Science, vol. 3459, pp. 217–229. Springer, Heidelberg (2005)
Engasser, H.C., Warshaw, E.M.: Dermatoscopy use by US dermatologists: a cross-sectional survey. J. Am. Acad. Dermatol. 63(3), 412–419 (2010)
Fieguth, P.: Statistical image processing and multidimensional modeling, vol. 155, p. 65. Springer, New York (2010)
Frankle, J.A., McCann, J.J.: Method and apparatus for lightness imaging. US Patent 4,384,336 (1983)
Glaister, J., Wong, A., Clausi, D.A.: Illumination correction in dermatological photographs using multi-stage illumination modeling for skin lesion analysis. In: EMBC’12: 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, San Diego, pp 102–105 (2012)
Haeghen, Y.V., Naeyaert, J.M.A.D., Lemahieu, I., Philips, W.: An imaging system with calibrated color image acquisition for use in dermatology. IEEE Trans. Med. Imaging 19(7), 722–730 (2000)
Herzog, C., Pappo, A., Bondy, M., Bleyer, A., Kirkwood, J.: Cancer Epidemiology in Older Adolescents and Young Adults 15 to 29 Years of Age, National Cancer Institute, Bethesda, MD, chap Malignant Melanoma, pp 53–64. NIH Pub. No. 06–5767 (2006)
Howlader, N., Noone, A.M., Krapcho, M., Neyman, N., Aminou, R., Altekruse, S.F., Kosary, C.L., Ruhl, J., Tatalovich, Z., Cho, H., Mariotto, A., Eisner, M.P., Lewish, D.R., Chen, H.S., Feuer, E.J.: Seer cancer statistics review, 1975–2009 (vintage 2009 populations). Technical report, Bethesda, MD (2012)
Hsu, C.W., Chang, C.C., Lin, C.J.: A practical guide to support vector classification (2010). http://www.cs.sfu.ca/people/Faculty/teaching/726/spring11/svmguide.pdf. Accessed 22 Nov 2012
Iyatomi, H., Celebi, M.E., Schaefer, G., Tanaka, M.: Automated color calibration method for dermoscopy images. Comput. Med. Imaging Graph. 35(2), 89–98 (2011)
Jemal, A., Siegel, R., Xu, J., Ward, E.: Cancer statistics, 2010. CA Cancer J. Clin. 60(5), 277–300 (2010)
Korotkov, K., Garcia, R.: Computerized analysis of pigmented skin lesions: A review. Artif. Intell. Med. 56(2), 69–90 (2012)
Land, E.H., McCann, J.J.: Lightness and retinex theory. J. Opt. Soc. Am. 61(1), 1–11 (1971)
Lee, T.K., Atkins, M.S., Gallagher, R.P., MacAulay, C.E., Coldman, A., McLean, D.I.: Describing the structural shape of melanocytic lesions. In: SPIE Medical Imaging, pp. 1170–1179 (1999)
Madooei, A., Drew, M.S., Sadeghi, M., Atkins, M.S.: Intrinsic melanin and hemoglobin colour components for skin lesion malignancy detection. In: Ayache, N., Delingette, H., Golland, P., Mori, K. (eds.) Medical Image Computing and Computer-Assisted Intervention MICCAI 2012, Lecture Notes in Computer Science, vol. 7510, pp. 315–322. Springer, Heidelberg (2012)
Maglogiannis, I., Doukas, C.N.: Overview of advanced computer vision systems for skin lesions characterization. IEEE Trans. Inf. Technol. Biomed. 13(5), 721–733 (2009)
Moncrieff, M., Cotton, S., Claridge, E., Hall, P.: Spectrophotometric intracutaneous analysis: a new technique for imaging pigmented skin lesions. Br. J. Dermatol. 146(3), 448–457 (2002)
Nachbar, F., Stolz, W., Merkle, T., Cognetta, A.B., Vogt, T., Landthaler, M., Bilek, P., Braun-Falco, O., Plewig, G.: The ABCD rule of dermatoscopy: high prospective value in the diagnosis of doubtful melanocytic skin lesions. J. Am. Acad. Dermatol. 30(4), 551–559 (1994)
National Center for Biotechnology Information: Melanoma—PubMed Health (2012). http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001853. Accessed 08 Nov 2012
Nock, R., Nielsen, F.: Statistical region merging. IEEE Trans. Pattern Anal. Mach. Intel. 26(11), 1452–1458 (2004)
Piatkowska, W., Martyna, J., Nowak, L., Przystalski, K.: A decision support system based on the semantic analysis of melanoma images using multi-elitist PSO and SVM. In: Perner, P. (ed.) Machine Learning and Data Mining in Pattern Recognition, Lecture Notes in Computer Science, vol. 6871, pp. 362–374. Springer, Heidelberg (2011)
van Rijsbergen, C.: Information Retrieval, 2nd edn. Butterworth-Heinemann, Newton (1979)
Schaefer, G., Rajab, M.I., Iyatomi, H.: Colour and contrast enhancement for improved skin lesion segmentation. Comput. Med. Imaging Graph. 35(2), 99–104 (2011)
Shan, S., Gao, W., Cao, B., Zhao, D.: Illumination normalization for robust face recognition against varying lighting conditions. In: AMFG’03: IEEE International Workshop on Analysis and Modeling of Faces and Gestures, Nice, pp. 157–164 (2003)
Smith, A.R.: Color gamut transform pairs. SIGGRAPH Comput. Graph. 12(3), 12–19 (1978)
Soille, P.: Morphological operators. Handb. Comput. Vis. Appl. 2, 627–682 (1999)
Stolz, W., Riemann, A., Cognetta, A., Pillet, L., Abmayr, W., Holzel, D., Bilek, P., Nachbar, F., Landthaler, M., Braun-Falco, O.: ABCD rule of dermatoscopy: a new practical method for early recognition of malignant melanoma. Eur. J. Dermatol. 4(7), 521–527 (1994)
Tsumura, N., Ojima, N., Sato, K., Shiraishi, M., Shimizu, H., Nabeshima, H., Akazaki, S., Hori, K., Miyake, Y.: Image-based skin color and texture analysis/synthesis by extracting hemoglobin and melanin information in the skin. ACM Trans. Graph. 22(3), 770–779 (2003)
Wallace, T.P., Wintz, P.A.: An efficient three-dimensional aircraft recognition algorithm using normalized fourier descriptors. Comput. Graph. Image Proces. 13(2), 99–126 (1980)
Wong, A., Clausi, D.A., Fieguth, P.: Adaptive monte carlo retinex method for illumination and reflectance separation and color image enhancement. In: CRV’09: Canadian Conference on Computer and Robot Vision, Kelowna, pp. 108–115 (2009)
World Health Organization: WHO |Skin cancers (2012). http://www.who.int/uv/faq/skincancer/en/index1.html. Accessed 08 Nov 2012
Acknowledgments
This research was sponsored by Agfa Healthcare Inc., Ontario Centres of Excellence (OCE), and the Natural Sciences and Engineering Research Council (NSERC) of Canada.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Amelard, R., Glaister, J., Wong, A., Clausi, D.A. (2014). Melanoma Decision Support Using Lighting-Corrected Intuitive Feature Models. In: Scharcanski, J., Celebi, M. (eds) Computer Vision Techniques for the Diagnosis of Skin Cancer. Series in BioEngineering. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-39608-3_7
Download citation
DOI: https://doi.org/10.1007/978-3-642-39608-3_7
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-39607-6
Online ISBN: 978-3-642-39608-3
eBook Packages: EngineeringEngineering (R0)