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Acute Irritancy Testing for Predicting Increased Susceptibility to Irritant Contact Dermatitis in Atopic Individuals

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Abstract

Epidemiological data provide evidence that atopic dermatitis confers an increased risk for development of chronic irritant dermatitis and raise the question whether experimentally-induced challenge may predict the enhanced susceptibility to irritant damage in atopic skin. The present chapter summarizes the scientific knowledge derived from the acute irritant exposure studies in individuals with atopic skin disease as well as respiratory atopy without dermatitis that have been published so far, with respect to the type of applied irritant, test conditions and measured endpoints.

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Author information

Authors and Affiliations

  1. Department of Dermatology, University of Lübeck, Ratzeburger Allee 160, Lübeck, 23538, Germany

    Irena Angelova-Fischer M.D., Ph.D.

  2. Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrueck, Sedanstr. 115, Osnabrueck, 49069, Germany

    Swen Malte John M.D.

  3. Coronel Institute of Occupational Health, Academic Medical Center, Meibergdreef 9, Amsterdam, AZ, 1105, The Netherlands

    Sanja Kezic Ph.D.

Authors
  1. Irena Angelova-Fischer M.D., Ph.D.
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  2. Swen Malte John M.D.
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  3. Sanja Kezic Ph.D.
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Correspondence to Irena Angelova-Fischer M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Department of Dermatology, Mayo Clinic, Rochester, Minnesota, USA

    Ali Alikhan

  2. Department of Dermatology, Catholic University of Louvain, Brussels, Belgium

    Jean-Marie Lachapelle

  3. Department of Dermatology, University of California, San Francisco, California, USA

    Howard I. Maibach

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Angelova-Fischer, I., John, S.M., Kezic, S. (2014). Acute Irritancy Testing for Predicting Increased Susceptibility to Irritant Contact Dermatitis in Atopic Individuals. In: Alikhan, A., Lachapelle, JM., Maibach, H. (eds) Textbook of Hand Eczema. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-39546-8_23

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