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Acute and Recurrent Vesicular Hand Eczema

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Textbook of Hand Eczema

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Abstract

Acute and recurrent vesicular hand eczema is an eczematous eruption on the palmar skin of patients for whom no external contactants can be identified as the cause of the eruptions.

The dermatitis may be seen as a reaction to oral drugs or to tinea pedis. Some studies show a relationship to atopy. Oral ingestion of the hapten in contact-sensitized patients may lead to recurrence of vesicular hand eczema.

Management includes attempts to identify the cause of the eruption. Pharmacological treatment is similar to that for other types of hand eczema.

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References

  1. Storrs F. Acute and recurrent vesicular hand dermatitis not pompholyx or dyshidrosis. Arch Dermatol. 2007;143(12):1578–80.

    Article  PubMed  Google Scholar 

  2. Kutzner H, Wurzel RM, Wolff HH. Are acrosyringia involved in the pathogenesis of “dyshidrosis”? Am J Dermatopathol. 1986;8(2):109–16.

    Article  CAS  PubMed  Google Scholar 

  3. Shelley WB. Dysidrosis (pompholyx). Arch Dermatol Syph. 1953;68:314–8.

    Article  CAS  Google Scholar 

  4. Christensen OB, Möller H. External and internal exposure to the allergen in the hand eczema of nickel allergy. Contact Dermatitis. 1975;1(3):136–41.

    Article  CAS  PubMed  Google Scholar 

  5. Menné T, Hjorth N. Pompholyx – dyshidrotic eczema. Semin Dermatol. 1983;2(1):75–80.

    Google Scholar 

  6. Lofgren SM, Warshaw EM. Dyshidrosis: epidemiology, clinical characteristics and therapy. Dermatitis. 2006;17(4):165–81.

    Article  PubMed  Google Scholar 

  7. Wollina U. Pompholyx. A review of clinical features, differential diagnosis, and management. Am J Clin Dermatol. 2010;11(5):306–14.

    Article  Google Scholar 

  8. Veien NK, Menné T. Acute and recurrent vesicular hand dermatitis (pompholyx). In: Menné T, Maibach H, editors. Hand eczema. 2nd ed. Boca Raton: CRC Press; 2000.

    Google Scholar 

  9. Veien NK. Acute and recurrent vesicular hand dermatitis. Dermatol Clin. 2009;27(3):337–53.

    Article  CAS  PubMed  Google Scholar 

  10. Agrup G. Hand eczema and other hand dermatoses in South Sweden [thesis]. Acta Derm Venereol. 1969;49 Suppl 61:1–91.

    Google Scholar 

  11. Thelin I, Agrup G. Pompholyx – a one year series. Acta Derm Venereol. 1985;65:214–7.

    CAS  PubMed  Google Scholar 

  12. Meding B. Epidemiology of hand eczema in an industrial city [dissertation]. Acta Derm Venereol. 1990;Suppl 153:1–43.

    Google Scholar 

  13. Johansen JD, Hald M, Andersen BL, Laurberg G, Danielsen A, Avnstorp C, et al. Classification of hand eczema: clinical and aetiological types. Based on the guideline of the Danish Contact Dermatitis Group. Contact Dermatitis. 2011;65(1):13–21.

    Article  PubMed  Google Scholar 

  14. Diepgen TL, Andersen KE, Brandao FM, Bruze M, Bruynzeel DP, Frosch P, et al., on behalf of the European Environmental and Contact Dermatitis Research Group. Hand eczema classification: a cross-sectional, multicentre study of the aetiology and morphology of hand eczema. Br J Dermatol. 2008;160:353–58.

    Google Scholar 

  15. Handa S, Kaur I, Gupta T, Jindal R. Hand eczema. Correlation of morphologic patterns, atopy, contact sensitization and disease severity. Indian J Dermatol Venereol Lepro. 2012;78(2):153–8.

    Article  Google Scholar 

  16. Meneghini CL, Angelini G. Contact and microbial allergy in pompholyx. Contact Dermatitis. 1979;5(1):46–50.

    Article  CAS  PubMed  Google Scholar 

  17. Lodi A, Betti R, Charelli G, Urbani CE, Crosti C. Epidemiological clinical and allergological observations on pompholyx. Contact Dermatitis. 1992;26(1):17–21.

    Article  CAS  PubMed  Google Scholar 

  18. Bryld LE, Agner T, Menné T. Relation between vesicular eruptions on the hands and tinea pedis, atopic dermatitis and nickel allergy. Acta Derm Venereol. 2003;83:186–8.

    Article  PubMed  Google Scholar 

  19. Pitché P, Boukari M, Tchangai-Walla K. Factors associated with palmoplantar or plantar pompholyx: a case-control study [in French]. Ann Dermatol Venereol. 2006;133(2):139–43.

    Article  PubMed  Google Scholar 

  20. Guillet MH, Wierzbicka E, Guillet S, Dagregorio G, Guillet G. A 3-year causative study of pompholyx in 120 patients. Arch Dermatol. 2007;143(12):1504–8.

    Article  PubMed  Google Scholar 

  21. Schwanitz HJ. Das atopische Palmoplantarekzem. Berlin: Springer; 1986.

    Book  Google Scholar 

  22. Kaaman T, Torssander J. Dermatophytid – a misdiagnosed entity? Acta Derm Venerol. 1983;63(5):404–8.

    CAS  PubMed  Google Scholar 

  23. Veien NK, Hattel T, Laurberg G. Plantar Trichophyton rubrum infections may cause dermatophytids on the hands. Acta Derm Venereol. 1994;74:403–4.

    CAS  PubMed  Google Scholar 

  24. Gerstenblith MR, Antony AK, Junkins-Hopkins JM, Abuav R. Pompholyx and eczematous reactions associated with intravenous immunoglobulin therapy. J Am Acad Dermatol. 2011;66(2):312–6.

    Article  PubMed  Google Scholar 

  25. Ekelund A-G, Möller H. Oral provocation in eczematous contact allergy to neomycin and hydroxyquinolines. Acta Derma Venerol. 1969;49:422–6.

    CAS  Google Scholar 

  26. Menné T, Weismann K. Hämatogenes Kontaktekzem nach oraler Gabe von Neomyzin. Hautarzt. 1984;35(6):319–20.

    PubMed  Google Scholar 

  27. Dorado Bris JM, Aragues Montañes M, Sols Candela M, Garcia DA. Contact sensitivity to pyrazinobutazone (Carudol®) with positive oral provocation test. Contact Dermatitis. 1992;26(5):355–6.

    Article  CAS  PubMed  Google Scholar 

  28. Piqué E, Pérez JA, Benjumeda A. Oral piroxicam-induced dyshidrosiform dermatitis. Contact Dermatitis. 2004;50(6):382–3.

    Article  PubMed  Google Scholar 

  29. Baeck M, Pilette C, Drieghe J, Goossens A. Allergic contact dermatitis to inhalation steroids. Eur J Dermatol. 2010;20(1):102–8.

    CAS  PubMed  Google Scholar 

  30. Möller H. Contact allergy to gold as a model for clinical-experimental research. Contact Dermatitis. 2010;62(4):193–200.

    Article  PubMed  Google Scholar 

  31. Burden AD, Wilkinson SM, Beck MH, Chalmers RJ. Garlic induced systemic contact dermatitis. Contact Dermatitis. 1994;30(5):299–300.

    Article  CAS  PubMed  Google Scholar 

  32. Oliwiecki S, Beck MH, Hausen BM. Compositae dermatitis aggravated by eating lettuce. Contact Dermatitis. 1991;24(4):318–9.

    Article  CAS  PubMed  Google Scholar 

  33. Dooms-Goosens A, Fubelloy R, Degreef H. Contact and systemic contact-type dermatitis to spices. Dermatol Clin. 1990;8(1):89–93.

    Google Scholar 

  34. Veien NK, Hattel T, Justesen O, Nørholm A. Oral challenge with balsam of Peru. Contact Dermatitis. 1985;12(2):104–7.

    Article  CAS  PubMed  Google Scholar 

  35. Niinimäki A. Delayed-type allergy to spices. Contact Dermatitis. 1984;11(1):34–40.

    Article  PubMed  Google Scholar 

  36. Niinimäki A. Double-blind placebo-controlled peroral challenges in patients with delayed-type allergy to balsam of Peru. Contact Dermatitis. 1995;33(2):78–83.

    Article  PubMed  Google Scholar 

  37. Schalock PC, Menné T, Johansen JD, Taylor JS, Maibach HI, Lidén C, et al. Hypersensitivity reactions to metallic implants – diagnostic algorithm and suggested patch test series for clinical use. Contact Dermatitis. 2012;66(1):4–19.

    Article  CAS  PubMed  Google Scholar 

  38. Kerosuo H, Kanerva L. Systemic contact dermatitis caused by nickel in a stainless steel orthodontic appliance. Contact Dermatitis. 1997;36(2):112–3.

    Article  CAS  PubMed  Google Scholar 

  39. Veien NK, Borchorst E, Hattel T, Laurberg G. Stomatitis of systemically-induced contact dermatitis from metal wire on orthodontic materials. Contact Dermatitis. 1994;30(4):210–3.

    Article  CAS  PubMed  Google Scholar 

  40. Smeenk G, Teunissen PC. Allergische reacties op nickel uit infusie-toedieningssystemen [in Dutch]. Ned Tijdscht Geneeskd. 1977;121:4–9.

    CAS  Google Scholar 

  41. Kanerva L, Förström L. Allergic nickel and chromate hand dermatitis induced by orthopaedic metal implant. Contact Dermatitis. 2001;44(2):103–4.

    Article  CAS  PubMed  Google Scholar 

  42. Bedello PG, Goitre M, Cane D, Roncarolo G. Nichel: aptene ubiquitario. [in Italian]. G Ital Dermatol Venereol. 1985;120(4):293–6.

    CAS  PubMed  Google Scholar 

  43. Hindsén M, Bruze M, Christensen OB. Flare-up reactions after oral challenge with nickel in relation to challenge dose and intensity and time of previous patch test reactions. J Am Acad Dermatol. 2001;44:616–23.

    Article  PubMed  Google Scholar 

  44. Veien NK, Hattel T, Justesen O, Nørholm A. Oral challenge with nickel and cobalt in patients with positive patch tests to nickel and/or cobalt. Acta Derm Venereol. 1987;67:321–6.

    CAS  PubMed  Google Scholar 

  45. Veien NK, Hattel T, Laurberg G. Placebo-controlled oral challenge with cobalt in patients with positive patch tests to cobalt. Contact Dermatitis. 1995;33(1):54–5.

    Article  CAS  PubMed  Google Scholar 

  46. Lein LR, Fowler Jr JF. Nickel dermatitis recall during disulfiram therapy for alcohol abuse. J Am Acad Dermatol. 1992;26(4):645–6.

    Article  Google Scholar 

  47. Menné T. Flare-up of cobalt dermatitis from Antabuse® treatment. Contact Dermatitis. 1985;12(1):53.

    Article  PubMed  Google Scholar 

  48. Yokozeki H, Katayama I, Nishioka K, Kinoshita M, Nishiyama S. The role of metal allergy and local hyperhidrosis in the pathogenesis of pompholyx. J Dermatol. 1992;19(12):964–7.

    CAS  PubMed  Google Scholar 

  49. Kaaber K, Veien NK. The significance of chromate ingestion in patients allergic to chromate. Acta Derm Venereol. 1977;57(4):321–3.

    CAS  PubMed  Google Scholar 

  50. Veien NK, Hattel T, Laurberg G. Chromate-allergic patients challenged orally with potassium dichromate. Contact Dermatitis. 1994;31(3):137–9.

    Article  CAS  PubMed  Google Scholar 

  51. Flood JM, Perry DJ. Role of food allergy in eczematoid dermatitis. Arch Dermatol Syphilol. 1947;55:493–506.

    Article  CAS  Google Scholar 

  52. Veien NK, Hattel T, Justesen O. Dermatoses in coffee drinkers. Cutis. 1987;40:421–2.

    Google Scholar 

  53. Man I, Ibbotson SH, Ferguson J. Photoinduced pompholyx: a report of 5 cases. J Am Acad Dermatol. 2004;50(1):55–60.

    Article  PubMed  Google Scholar 

  54. Miller RM, Coger RW. Skin conductance conditioning with dyshidrotic eczema patients. Br J Dermatol. 1979;101:435–40.

    Article  CAS  PubMed  Google Scholar 

  55. Koldys KW, Meyer RP. Biofeedback training in the therapy of dyshidrosis. Cutis. 1979;24:219–21.

    CAS  PubMed  Google Scholar 

  56. Chen J-J, Liang Y-H, Zhou F-S, Yang S, Wang J, Wang PG, et al. The gene for a rare autosomal dominant form of pompholyx maps to chromosome 18q22.1–18q22.3. J Invest Dermatol. 2006;126(2):300–4.

    Article  CAS  PubMed  Google Scholar 

  57. Patrizi A, Rizzoli L, Benassi L, Nerit I. Another case of dyshidrosiform pemphigoid. Eur Acad Dermatol Venereol. 2003;17:348–72.

    Article  Google Scholar 

  58. Lupi F, Masini C, Ruffelli M, Puddu P, Cianchini G. Dyshidrosiform palmoplantar pemphigoid in a young man: response to dapsone. Acta Derm Venereol. 2010;90(1):80–1.

    Article  PubMed  Google Scholar 

  59. Vocks E, Plötz SG, Ring J. The dyshidrotic eczema area and severity index – a score developed for the assessment of dyshidrotic eczema. Dermatology. 1999;198(3):265–9.

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Dermatology Clinic, Fyrkildevej 7, Aalborg, 9220, Denmark

    Niels K. Veien M.D., Ph.D.

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  1. Niels K. Veien M.D., Ph.D.
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Correspondence to Niels K. Veien M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Department of Dermatology, Mayo Clinic, Rochester, Minnesota, USA

    Ali Alikhan

  2. Department of Dermatology, Catholic University of Louvain, Brussels, Belgium

    Jean-Marie Lachapelle

  3. Department of Dermatology, University of California, San Francisco, California, USA

    Howard I. Maibach

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Veien, N.K. (2014). Acute and Recurrent Vesicular Hand Eczema. In: Alikhan, A., Lachapelle, JM., Maibach, H. (eds) Textbook of Hand Eczema. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-39546-8_13

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  • DOI: https://doi.org/10.1007/978-3-642-39546-8_13

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