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Computed Tomography of the Lung pp 81–101Cite as

Nodular Pattern

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Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

Abstract

The CT assessment of the nodular pattern, which is characterised by the presence of multiple nodular opacities with a maximum diameter of 3 cm, is typically based on the study of the nodule characteristics (appearance pattern) and on the study of the distribution of the nodules (distribution pattern). This chapter explains how the study of the borders and the density of the nodules together with the study of their regional distribution and of their relation to the components of the secondary pulmonary lobule is very helpful in the diagnosis.

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References

  • Akira M (2002) High-resolution CT in the evaluation of occupational and environmental disease. Radiol Clin North Am 40:43–59

    Article  PubMed  Google Scholar 

  • Akira M, Kitatani F, Lee Y-S et al (1988) Diffuse panbronchiolitis: evaluation with high-resolution CT. Radiology 168:433–438

    Article  CAS  PubMed  Google Scholar 

  • Akira M, Atagi S, Kawahara M et al (1999) High-resolution CT findings of diffuse bronchioloalveolar carcinoma in 38 patients. AJR Am J Roentgenol 173:1623–1629

    Article  CAS  PubMed  Google Scholar 

  • Akira M, Kozuka T, Inoue Y et al (2005) Long-term follow-up CT scan evaluation in patients with pulmonary sarcoidosis. Chest 127:185–191

    Article  PubMed  Google Scholar 

  • Andreu J, Mauleon S, Pallisa E et al (2002) Miliary lung disease revisited. Curr Probl Diagn Radiol 31:189–197

    Article  CAS  PubMed  Google Scholar 

  • Antao VC, Pinheiro GA, Terra-Filho M et al (2005) High-resolution CT in silicosis: correlation with radiographic findings and functional impairment. J Comput Assist Tomogr 29:350–356

    Article  PubMed  Google Scholar 

  • Aquino SL, Gamsu G, Webb WR et al (1996) Tree-in-bud pattern: frequency and significance on thin section CT. J Comput Assist Tomogr 20:594–599

    Article  CAS  PubMed  Google Scholar 

  • Austin J, Muller N, Friedman P et al (1996) Glossary of terms for CT of the lungs: recommendations of the nomenclature committee of the Fleischner Society. Radiology 200:327–331

    Article  CAS  PubMed  Google Scholar 

  • Ayuso MC, Gilabert R, Bombi JA et al (1987) CT appearance of localized pulmonary amyloidosis. J Comput Assist Tomogr 11:197–199

    Article  CAS  PubMed  Google Scholar 

  • Bégin R, Bergeron D, Samson L et al (1987) CT assessment of silicosis in exposed workers. AJR Am J Roentgenol 148:509–514

    Article  PubMed  Google Scholar 

  • Bergin CJ, Müller NL (1987) CT of interstitial lung disease: a diagnostic approach. AJR Am J Roentgenol 148:9–15

    Article  CAS  PubMed  Google Scholar 

  • Bergin CJ, Bell DY, Coblentz CL et al (1989) Sarcoidosis: correlation of pulmonary parenchymal pattern at CT with results of pulmonary function tests. Radiology 171:619–624

    Article  CAS  PubMed  Google Scholar 

  • Braun SR, DoPico GA, Tsiatis A et al (1979) Farmer’s lung disease: long-term clinical and physiologic outcome. Am Rev Respir Dis 119:185–191

    CAS  PubMed  Google Scholar 

  • Brauner MW, Grenier P, Mompoint D et al (1989) Pulmonary sarcoidosis: evaluation with high-resolution CT. Radiology 172:467–471

    Article  CAS  PubMed  Google Scholar 

  • Brauner MW, Lenoir S, Grenier P et al (1992) Pulmonary sarcoidosis: CT assessment of lesion reversibility. Radiology 182:349–354

    Article  CAS  PubMed  Google Scholar 

  • Brown K, Mund DF, Aberle DR et al (1994) Intrathoracic calcifications: radiographic features and differential diagnosis. Radiographics 14:1247–1261

    Article  CAS  PubMed  Google Scholar 

  • Chan ED, Morales DV, Welsh CH et al (2002) Calcium deposition with or without bone formation in the lung. Am J Respir Crit Care Med 165:1654–1669

    Article  PubMed  Google Scholar 

  • Cluzel P, Grenier P, Bernadac P et al (1991) Pulmonary alveolar microlithiasis: CT findings. J Comput Assist Tomogr 15:938–942

    Article  CAS  PubMed  Google Scholar 

  • Colby TV, Swensen SJ (1996) Anatomic distribution and histopathologic patterns in diffuse lung disease: correlation with HRCT. J Thorac Imaging 11:1–26

    Article  CAS  PubMed  Google Scholar 

  • Collins J (2001) CT signs and patterns of lung disease. Radiol Clin North Am 39:1115–1135

    Article  CAS  PubMed  Google Scholar 

  • Collins J, Blankenbaker D, Stern EJ (1998) CT patterns of bronchiolar disease: what is tree-in-bud? AJR Am J Roentgenol 171:365–370

    Article  CAS  PubMed  Google Scholar 

  • Cotton A, Boutry N, Cortet B (1998) Percutaneous vertebroplasty: state of the art. Radiographics 18:311–320

    Article  Google Scholar 

  • Dawson WB, Müller NL (1990) High-resolution computed tomography in pulmonary sarcoidosis. Semin Ultrasound CT MR 11:423–429

    CAS  PubMed  Google Scholar 

  • Eisenhuber E (2002) The tree-in-bud sign. Radiology 222:771–772

    Article  PubMed  Google Scholar 

  • Franquet T, Giménez A, Prats R et al (2002) Thrombotic microangiopathy of pulmonary tumors: a vascular cause of tree-in-bud pattern on CT. AJR 179:897–899

    Article  PubMed  Google Scholar 

  • Gaeta M, Blandino A, Scribano E et al (1999) Computed tomography halo sign of pulmonary nodules: frequency and diagnostic value. J Thorac Imaging 14:109–113

    Article  CAS  PubMed  Google Scholar 

  • Gallardo X, Castaner E, Mata J et al (2006) Nodular pattern at lung computed tomography in fat embolism syndrome. A helpful finding. J Comput Assist Tomogr 30:254–257

    Article  PubMed  Google Scholar 

  • Graham CM, Stern EJ, Finkbeiner WE et al (1992) High-resolution CT appearance of diffuse alveolar septal amyloidosis. AJR Am J Roentgenol 158:265–267

    Article  CAS  PubMed  Google Scholar 

  • Grenier P, Valeyre D, Cluzel P et al (1991) Chronic diffuse interstitial lung disease: diagnostic value of chest radiography and high-resolution CT. Radiology 179:123–132

    Article  CAS  PubMed  Google Scholar 

  • Gross BH, Schneider HJ, Proto AV (1980) Eggshell calcification of lymph nodes: an update. AJR Am J Roentgenol. 135(6):1265–1268

    Google Scholar 

  • Gruden JF, Webb WR (1995) Identification and evaluation of centrilobular opacities on high-resolution CT. Semin Ultrasound CT MR 16:435–449

    Article  CAS  PubMed  Google Scholar 

  • Gruden JF, Webb WR, Warnock M (1994) Centrilobular opacities in the lung on high-resolution CT: diagnostic considerations and pathologic correlation. AJR Am J Roentgenol 162:569–574

    Article  CAS  PubMed  Google Scholar 

  • Hansell DM, Bankier A, MacMahon H et al (2008) Fleischner society: glossary of terms for thoracic imaging. Radiology 246:697–722

    Article  PubMed  Google Scholar 

  • Heo JN, Choi YW, Jeon SC et al (2005) Pulmonary tuberculosis: another disease showing clusters of small nodules. AJR Am J Roentgenol 184(2):639–642

    Article  PubMed  Google Scholar 

  • Hirakata K, Nakata H, Haratake J (1993) Appearance of pulmonary metastases on high-resolution CT scans: comparison with histopathologic findings from autopsy specimens. AJR Am J Roentgenol 161:37–43

    Article  CAS  PubMed  Google Scholar 

  • Honda O, Johkoh T, Icfhikado K et al (1999) Differential diagnosis of lymphocytic interstitial pneumonia and malignant lymphoma on high-resolution CT. AJR Am J Roentgenol 173:71–74

    Article  CAS  PubMed  Google Scholar 

  • Hong SH, Im JG, Lee JS et al (1998) High resolution CT findings of military tuberculosis. J Comput Assist Tomogr 22:220–224

    Article  CAS  PubMed  Google Scholar 

  • Howling SJ, Hansell DM, Wells AU et al (1999) Follicular bronchiolitis: thin-section CT and histologic findings. Radiology 212:637–642

    Article  CAS  PubMed  Google Scholar 

  • Im JG, Itoh H, Shim YS et al (1993) Pulmonary tuberculosis: CT findings – early active disease and sequential change with antituberculous therapy. Radiology 186:653–660

    Article  CAS  PubMed  Google Scholar 

  • Im JG, Itoh H, Han MC (1995) CT of pulmonary tuberculosis. Semin Ultrasound CT MR 16:420–434

    Article  CAS  PubMed  Google Scholar 

  • Itoh H, Tokunaga S, Asamoto H et al (1978) Radiologic-pathologic correlations of small lung nodules with special reference to peribronchiolar nodules. AJR Am J Roentgenol 130:223–231

    Article  CAS  PubMed  Google Scholar 

  • Johkoh T, Ikezoe J, Tomiyama N et al (1992) CT findings in lymphangitic carcinomatosis of the lung: correlation with histologic findings and pulmonary function tests. AJR Am J Roentgenol 158:1217–1222

    Article  CAS  PubMed  Google Scholar 

  • Johkoh T, Muller NL, Pickford HA et al (1999) Lymphocytic interstitial pneumonia: thin-section CT findings in 22 patients. Radiology 212:567–572

    Article  CAS  PubMed  Google Scholar 

  • Kim HY, Im J-G, Song K-S et al (1999) Localized amyloidosis of the respiratory system: CT features. J Comput Assist Tomogr 23:627–631

    Article  CAS  PubMed  Google Scholar 

  • Kokkarinen J, Tukiainen H, Terho EO (1994) Mortality due to farmer’s lung in Finland. Chest 106:509–512

    Article  CAS  PubMed  Google Scholar 

  • Lee KS, Kim TS, Han J et al (1999) Diffuse micronodular lung disease: HRCT and pathologic findings. J Comput Assist Tomogr 23:99–106

    Article  CAS  PubMed  Google Scholar 

  • Lynch DA, Webb WR, Gamsu G et al (1989) Computed tomography in pulmonary sarcoidosis. J Comput Assist Tomogr 13:405–410

    Article  CAS  PubMed  Google Scholar 

  • Lynch DA, Brasch RC, Hardy KA et al (1990) Pediatric pulmonary disease: assessment with high-resolution ultrafast CT. Radiology 176:243–248

    Article  CAS  PubMed  Google Scholar 

  • Maile CW, Rodan BA, Godwin JD et al (1982) Calcification in pulmonary metastases. Br J Radiol 55:108–113

    Article  CAS  PubMed  Google Scholar 

  • Marchiori E, Souza AS, Franquet T et al (2005) Diffuse high-attenuation pulmonary abnormalities: a pattern-oriented diagnostic approach on high-resolution CT. AJR Am J Roentgenol 184:273–282

    Article  PubMed  Google Scholar 

  • Marchiori E, Zanetti G, Hochhegger B et al (2011) Sarcoid cluster sign and the reversed halo sign: extending the spectrum of radiographic manifestations in sarcoidosis. Eur J Radiol 80(2):567–568

    Google Scholar 

  • Milne EN, Zerhouni EA (1987) Blood supply of pulmonary metastases. J Thorac Imaging 2:15–23

    Article  CAS  PubMed  Google Scholar 

  • Mohr LC (2004) Hypersensitivity pneumonitis. Curr Opin Pulm Med 10:401–411

    Article  PubMed  Google Scholar 

  • Muller N, Fraser R, Lee K et al (2003a) Pulmonary infection. In: Muller N, Fraser R, Lee K (eds) Diseases of the lung. Radiologic and pathologic correlations, 1st edn. Lippincott, Philadelphia, pp 17–76

    Google Scholar 

  • Muller N, Fraser R, Lee K et al (2003b) Occupational lung disease. In: Muller N, Fraser R, Lee K (eds) Diseases of the lung. Radiologic and pathologic correlations, 1st edn. Lippincott, Philadelphia, pp 183–207

    Google Scholar 

  • Muller N, Fraser R, Lee K et al (2003c) Bronchiolitis. In: Muller N, Fraser R, Lee K (eds) Diseases of the lung. Radiologic and pathologic correlations, 1st edn. Lippincott, Philadelphia, pp 287–307

    Google Scholar 

  • Muller N, Fraser R, Lee K et al (2003d) Miscellaneous pulmonary diseases. In: Muller N, Fraser R, Lee K (eds) Diseases of the lung. Radiologic and pathologic correlations, 1st edn. Lippincott, Philadelphia, pp 352–376

    Google Scholar 

  • Müller NL, Kullnig P, Miller RR (1989) The CT findings of pulmonary sarcoidosis: analysis of 25 patients. AJR Am J Roentgenol 152:1179–1182

    Article  PubMed  Google Scholar 

  • Müller NL, Miller RR (1995) Diseases of the bronchioles: CT and histopathologic findings. Radiology 196:3–12

    Article  PubMed  Google Scholar 

  • Murata K, Itoh H, Todo G et al (1986) Centrilobular lesions of the lung: demonstration by high-resolution CT and pathologic correlation. Radiology 161:641–645

    Article  CAS  PubMed  Google Scholar 

  • Murata K, Herman PG, Khan A et al (1989) Intralobular distribution of oleic acid-induced pulmonary edema in the pig: evaluation by high-resolution CT. Invest Radiol 24:647–653

    Article  CAS  PubMed  Google Scholar 

  • Murata K, Takahashi M, Mori M et al (1992) Pulmonary metastatic nodules: CT-pathologic correlation. Radiology 182:331–335

    Article  CAS  PubMed  Google Scholar 

  • Naidich DP, Zerhouni EA, Hutchins GM et al (1985) Computed tomography of the pulmonary parenchyma. Part 1: distal airspace disease. J Thorac Imaging 1:39–53

    Article  CAS  PubMed  Google Scholar 

  • Nakatsu M, Hatabu H, Morikawa K et al (2002) Large coalescent parenchymal nodules in pulmonary sarcoidosis: “sarcoidgalaxy” sign. AJR Am J Roentgenol 178(6):1389–1393

    Google Scholar 

  • Nishimura K, Kitaichi M, Izumi T et al (1992) Diffuse panbronchiolitis: correlation of high-resolution CT and pathologic findings. Radiology 184:779–785

    Article  CAS  PubMed  Google Scholar 

  • Nishimura K, Itoh H, Kitaichi M et al (1993) Pulmonary sarcoidosis: correlation of CT and histopathologic findings. Radiology 189:105–109

    Article  CAS  PubMed  Google Scholar 

  • Oh YW, Kim YH, Lee NJ et al (1994) High-resolution CT appearance of miliary tuberculosis. J Comput Asist Tomogr 18:862–866

    Article  CAS  Google Scholar 

  • Okada F, Ando Y, Yoshitake S et al (2007) Clinical/pathologic correlations in 553 patients with primary centrilobular findings on high-resolution CT scan of the thorax. Chest 132(6):1939–1948

    Google Scholar 

  • Paslawski M, Szafranek J, Krupski W et al (2003) Differentiation of etiology of nodular changes in high resolution computed tomography (HRCT) in interstitial lung diseases. Ann Univ Mariae Curie Sklodowska 58:370–377

    Google Scholar 

  • Patti A, Tognini G, Spaggiari E et al (2004) Diffuse, micronodular lung disease. The high-resolution CT approach. A pictorial essay. Radiol Med (Torino) 107:139–144

    Google Scholar 

  • Raoof S, Amchentsev A, Vlahos I et al (2006) Pictorial essay: multinodular disease. A high-resolution CT scan diagnostic algorithm. Chest 129:805–815

    Article  PubMed  Google Scholar 

  • Remy-Jardin M, Beuscart R, Sault MC et al (1990) Subpleural micronodules in diffuse infiltrative lung diseases: evaluation with thin-section CT scans. Radiology 177:133–139

    Article  CAS  PubMed  Google Scholar 

  • Remy-Jardin M, Remy J, Boulenguez C et al (1993a) Morphologic effects of cigarette smoking on airways and pulmonary parenchyma in healthy adult volunteers: CT evaluation and correlation with pulmonary function tests. Radiology 186:107–115

    Article  CAS  PubMed  Google Scholar 

  • Remy-Jardin M, Remy J, Gosselin B et al (1993b) Lung parenchymal changes secondary to cigarette smoking: pathologic CT correlations. Radiology 186:643–651

    Article  CAS  PubMed  Google Scholar 

  • Ren H, Hruban RH, Kuhlman JE et al (1989) Computed tomography of inflation-fixed lungs: the beaded septum sign of pulmonary metastases. J Comput Assist Tomogr 13:411–416

    Article  CAS  PubMed  Google Scholar 

  • Tsuchiya R (2005) Implication of the CT characteristics of subcentimeter pulmonary nodules. Semin Thorac Cardiovasc Surg 17:107–109

    Article  PubMed  Google Scholar 

  • Urban BA, Fishman EK, Goldman SM et al (1993) CT evaluation of amyloidosis: spectrum of disease. Radiographics 13:1295–1308

    Article  CAS  PubMed  Google Scholar 

  • Utz JP, Swensen SJ, Gertz MA (1996) Pulmonary amyloidosis. The Mayo clinic experience from 1980 to 1993. Ann Intern Med 124:407–413

    Article  CAS  PubMed  Google Scholar 

  • Voloudaki AE, Tritou IN, Magkanas EG et al (1999) HRCT in miliary lung disease. Acta Radiol 40:451–456

    Article  CAS  PubMed  Google Scholar 

  • Ward S, Heyneman LE, Reittner P et al (2000) Talcosis associated with IV abuse of oral medications: CT findings. AJR Am J Roentgenol 174:789–793

    Article  CAS  PubMed  Google Scholar 

  • Webb WR (1989) High-resolution CT of the lung parenchyma. Radiol Clin North Am 27:1085–1097

    CAS  PubMed  Google Scholar 

  • Xia L, Li E, Gong J et al (2002) Role of high resolution CT in pulmonary nodules. Zhonghua Zhong Liu Za Zhi 24:494–496

    PubMed  Google Scholar 

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  1. Department of Radiology, UZ Leuven, Leuven, Belgium

    Johny A. Verschakelen & Walter De Wever

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  1. Johny A. Verschakelen
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  2. Walter De Wever
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Verschakelen, J.A., De Wever, W. (2018). Nodular Pattern. In: Computed Tomography of the Lung. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-39518-5_6

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  • DOI: https://doi.org/10.1007/978-3-642-39518-5_6

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