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Influenza Infection in the Elderly

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Immunology of Aging

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Abstract

Influenza is a febrile respiratory disease, which is usually associated with a mild acute self-limited illness. However, certain risk factors, including ageing, are associated with severity of disease and the occurrence of influenza-related complications. Influenza infection has shown to be foremost among all infectious diseases in its association with an age-related increase in the incidence of serious complications. A decrease in immune function is a hallmark of ageing that imposes negative effects in its ability to resist influenza virus infection and its response to vaccination. It has been recognized that the ageing process affects both branches of the immune system, namely, the innate and adaptive immune systems.

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Authors and Affiliations

  1. Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA

    Kasra Moazzami MD, MPH

  2. Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, BC, Canada

    Janet E. McElhaney MD, FRCPC, FACP

  3. Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran

    Nima Rezaei MD, MSc, PhD

  4. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Nima Rezaei MD, MSc, PhD

  5. Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran

    Nima Rezaei MD, MSc, PhD

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  1. Kasra Moazzami MD, MPH
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  2. Janet E. McElhaney MD, FRCPC, FACP
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  3. Nima Rezaei MD, MSc, PhD
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Correspondence to Nima Rezaei MD, MSc, PhD .

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Editors and Affiliations

  1. Department of Immunology, Tehran University of Medical Sciences School of Medicine, Tehran, Iran

    Ahmad Massoud

  2. Children's Medical Center Hospital, Tehran University of Medical Sciences Research Center for Immunodeficiencies, Tehran, Iran

    Nima Rezaei

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Moazzami, K., McElhaney, J.E., Rezaei, N. (2014). Influenza Infection in the Elderly. In: Massoud, A., Rezaei, N. (eds) Immunology of Aging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-39495-9_18

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