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Biological and Phenotypic Alterations of T Cells in Aging

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Immunology of Aging

Abstract

The deleterious effects of ageing on the T cell compartment are well studied, as they lead to increased susceptibility to infections, cancers, and autoimmunity in elders. Ageing reduces the number and T cell potential of hematopoietic precursors, and involution of the thymus renders it less capable of supporting de novo T cell development. Consequently, ageing compromises the functions of lymphocytes, resulting in a T cell pool with restricted receptor specificity and fewer naïve T cells.

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References

  • Alam I, Larbi A, Pawelec G (2012) Nutritional status influences peripheral immune cell phenotypes in healthy men in rural Pakistan. Immun Ageing 9(1):16

    Article  PubMed  CAS  Google Scholar 

  • Alvarado C, Alvarez P, Puerto M et al (2006) Dietary supplementation with antioxidants improves functions and decreases oxidative stress of leukocytes from prematurely aging mice. Nutrition 22(7–8):767–777

    Article  PubMed  CAS  Google Scholar 

  • Behzad H, Huckriede AL, Haynes L et al (2012) GLA-SE, a synthetic toll-like receptor 4 agonist, enhances T-cell responses to influenza vaccine in older adults. J Infect Dis 205(3):466–473

    Article  PubMed  CAS  Google Scholar 

  • Chen BJ, Cui X, Sempowski GD et al (2003) Growth hormone accelerates immune recovery following allogeneic T-cell-depleted bone marrow transplantation in mice. Exp Hematol 31(10):953–958

    Article  PubMed  CAS  Google Scholar 

  • Chen BJ, Deoliveira D, Spasojevic I et al (2010) Growth hormone mitigates against lethal irradiation and enhances hematologic and immune recovery in mice and nonhuman primates. PLoS One 5(6):e11056

    Article  PubMed  Google Scholar 

  • Chidgey AP, Boyd RL (2006) Stemming the tide of thymic aging. Nat Immunol 7(10):1013–1016

    Article  PubMed  CAS  Google Scholar 

  • Chou JP, Effros RB (2013) T cell replicative senescence in human aging. Curr Pharm Des 19(9):1680–1698

    PubMed  CAS  Google Scholar 

  • Curtsinger JM, Schmidt CS, Mondino A et al (1999) Inflammatory cytokines provide a third signal for activation of naive CD4+ and CD8+ T cells. J Immunol 162(6):3256–3262

    PubMed  CAS  Google Scholar 

  • Douziech N, Seres I, Larbi A et al (2002) Modulation of human lymphocyte proliferative response with aging. Exp Gerontol 37(2–3):369–387

    Article  PubMed  CAS  Google Scholar 

  • Eaton SM, Maue AC, Swain SL et al (2008) Bone marrow precursor cells from aged mice generate CD4 T cells that function well in primary and memory responses. J Immunol 181(7):4825–4831

    PubMed  CAS  Google Scholar 

  • Effros RB (2003) Genetic alterations in the ageing immune system: impact on infection and cancer. Mech Ageing Dev 124(1):71–77

    Article  PubMed  CAS  Google Scholar 

  • Engwerda CR, Fox BS, Handwerger BS (1996) Cytokine production by T lymphocytes from young and aged mice. J Immunol 156(10):3621–3630

    PubMed  CAS  Google Scholar 

  • Goldberg GL, Sutherland JS, Hammet MV et al (2005) Sex steroid ablation enhances lymphoid recovery following autologous hematopoietic stem cell transplantation. Transplantation 80(11):1604–1613

    Article  PubMed  Google Scholar 

  • Goldberg GL, Alpdogan O, Muriglan SJ et al (2007) Enhanced immune reconstitution by sex steroid ablation following allogeneic hemopoietic stem cell transplantation. J Immunol 178(11):7473–7484

    PubMed  CAS  Google Scholar 

  • Haynes L, Swain SL (2006) Why aging T cells fail: implications for vaccination. Immunity 24(6):663–666

    Article  PubMed  CAS  Google Scholar 

  • Haynes L, Linton PJ, Eaton SM et al (1999) Interleukin 2, but not other common gamma chain-binding cytokines, can reverse the defect in generation of CD4 effector T cells from naive T cells of aged mice. J Exp Med 190(7):1013–1024

    Article  PubMed  CAS  Google Scholar 

  • Haynes L, Eaton SM, Burns EM et al (2003) CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly. Proc Natl Acad Sci U S A 100(25):15053–15058

    Article  PubMed  CAS  Google Scholar 

  • Haynes L, Eaton SM, Burns EM et al (2004) Inflammatory cytokines overcome age-related defects in CD4 T cell responses in vivo. J Immunol 172(9):5194–5199

    PubMed  CAS  Google Scholar 

  • Heng TS, Chidgey AP, Boyd RL (2010) Getting back at nature: understanding thymic development and overcoming its atrophy. Curr Opin Pharmacol 10(4):425–433

    Article  PubMed  CAS  Google Scholar 

  • Henson SM, Akbar AN (2010) Memory T-cell homeostasis and senescence during aging. Adv Exp Med Biol 684:189–197

    PubMed  CAS  Google Scholar 

  • High KP, Akbar AN, Nikolich-Zugich J (2012) Translational research in immune senescence: assessing the relevance of current models. Semin Immunol 24(5):373–382

    Article  PubMed  CAS  Google Scholar 

  • Hobbs MV, Ernst DN, Torbett BE et al (1991) Cell proliferation and cytokine production by CD4+ cells from old mice. J Cell Biochem 46(4):312–320

    Article  PubMed  CAS  Google Scholar 

  • Holland AM, van den Brink MR (2009) Rejuvenation of the aging T cell compartment. Curr Opin Immunol 21(4):454–459

    Article  PubMed  CAS  Google Scholar 

  • Hosaka N, Nose M, Kyogoku M et al (1996) Thymus transplantation, a critical factor for correction of autoimmune disease in aging MRL/+mice. Proc Natl Acad Sci U S A 93(16):8558–8562

    Article  PubMed  CAS  Google Scholar 

  • Kapasi ZF, Murali-Krishna K, McRae ML et al (2002) Defective generation but normal maintenance of memory T cells in old mice. Eur J Immunol 32(6):1567–1573

    Article  PubMed  CAS  Google Scholar 

  • Kaszubowska L (2008) Telomere shortening and ageing of the immune system. J Physiol Pharmacol 59(Suppl 9):169–186

    PubMed  Google Scholar 

  • Kilpatrick RD, Rickabaugh T, Hultin LE et al (2008) Homeostasis of the naive CD4+ T cell compartment during aging. J Immunol 180(3):1499–1507

    PubMed  CAS  Google Scholar 

  • Klinman NR, Kline GH (1997) The B-cell biology of aging. Immunol Rev 160:103–114

    Article  PubMed  CAS  Google Scholar 

  • Kwon TK, Nagel JE, Buchholz MA et al (1996) Characterization of the murine cyclin-dependent kinase inhibitor gene p27Kip1. Gene 180(1–2):113–120

    Article  PubMed  CAS  Google Scholar 

  • Lee N, Shin MS, Kang I (2012) T-cell biology in aging, with a focus on lung disease. J Gerontol A Biol Sci Med Sci 67(3):254–263

    Article  PubMed  Google Scholar 

  • Linton PJ, Dorshkind K (2004) Age-related changes in lymphocyte development and function. Nat Immunol 5(2):133–139

    Article  PubMed  CAS  Google Scholar 

  • Lustyik G, O’Leary JJ (1989) Aging and the mobilization of intracellular calcium by phytohemagglutinin in human T cells. J Gerontol 44(2):B30–B36

    Article  PubMed  CAS  Google Scholar 

  • Maue AC, Eaton SM, Lanthier PA et al (2009) Proinflammatory adjuvants enhance the cognate helper activity of aged CD4 T cells. J Immunol 182(10):6129–6135

    Article  PubMed  CAS  Google Scholar 

  • McLeod JD (2000) Apoptotic capability in ageing T cells. Mech Ageing Dev 121(1–3):151–159

    PubMed  CAS  Google Scholar 

  • Minematsu T, Yamamoto Y, Nagase T et al (2011) Aging enhances maceration-induced ultrastructural alteration of the epidermis and impairment of skin barrier function. J Dermatol Sci 62(3):160–168

    Article  PubMed  CAS  Google Scholar 

  • Noble JM, Ford GA, Thomas TH (1999) Effect of aging on CD11b and CD69 surface expression by vesicular insertion in human polymorphonuclear leucocytes. Clin Sci (Lond) 97(3):323–329

    Article  CAS  Google Scholar 

  • Pae M, Meydani SN, Wu D (2012) The role of nutrition in enhancing immunity in aging. Ageing Dis 3(1):91–129

    Google Scholar 

  • Ponnappan U (2002) Ubiquitin-proteasome pathway is compromised in CD45RO + and CD45RA + T lymphocyte subsets during aging. Exp Gerontol 37(2–3):359–367

    Article  PubMed  CAS  Google Scholar 

  • Santiago AF, Alves AC, Oliveira RP et al (2011) Aging correlates with reduction in regulatory-type cytokines and T cells in the gut mucosa. Immunobiology 216(10):1085–1093

    Article  PubMed  CAS  Google Scholar 

  • Sempowski GD, Gooding ME, Liao HX et al (2002) T cell receptor excision circle assessment of thymopoiesis in aging mice. Mol Immunol 38(11):841–848

    Article  PubMed  CAS  Google Scholar 

  • Strasser A, Sonnek U, Niedermuller H (1997) Age-related changes in plasma IgM level after SRBC-stimulation in the rat. Arch Gerontol Geriatr 25(3):277–284

    Article  PubMed  CAS  Google Scholar 

  • Tamura T, Kunimatsu T, Yee ST et al (2000) Molecular mechanism of the impairment in activation signal transduction in CD4(+) T cells from old mice. Int Immunol 12(8):1205–1215

    Article  PubMed  CAS  Google Scholar 

  • von Freeden-Jeffry U, Solvason N, Howard M et al (1997) The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression. Immunity 7(1):147–154

    Article  Google Scholar 

  • Weinberger B, Grubeck-Loebenstein B (2012) Vaccines for the elderly. Clin Microbiol Infect 18(Suppl 5):100–108

    Article  PubMed  CAS  Google Scholar 

  • Welniak LA, Sun R, Murphy WJ (2002) The role of growth hormone in T-cell development and reconstitution. J Leukoc Biol 71(3):381–387

    PubMed  CAS  Google Scholar 

  • Zhou X, McElhaney JE (2011) Age-related changes in memory and effector T cells responding to influenza A/H3N2 and pandemic A/H1N1 strains in humans. Vaccine 29(11):2169–2177

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Ahmad Massoud PharmD, MPH, PhD

  2. Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada

    Amir Hossein Massoud PhD

  3. Meakins-Christie Laboratories, McGill University, Montreal, QC, H2X-2P2, Canada

    Amir Hossein Massoud PhD

Authors
  1. Ahmad Massoud PharmD, MPH, PhD
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  2. Amir Hossein Massoud PhD
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Corresponding author

Correspondence to Ahmad Massoud PharmD, MPH, PhD .

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Editors and Affiliations

  1. Department of Immunology, Tehran University of Medical Sciences School of Medicine, Tehran, Iran

    Ahmad Massoud

  2. Children's Medical Center Hospital, Tehran University of Medical Sciences Research Center for Immunodeficiencies, Tehran, Iran

    Nima Rezaei

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© 2014 Springer-Verlag Berlin Heidelberg

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Massoud, A., Massoud, A.H. (2014). Biological and Phenotypic Alterations of T Cells in Aging. In: Massoud, A., Rezaei, N. (eds) Immunology of Aging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-39495-9_11

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  • DOI: https://doi.org/10.1007/978-3-642-39495-9_11

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-39494-2

  • Online ISBN: 978-3-642-39495-9

  • eBook Packages: MedicineMedicine (R0)

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