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T Cell-Mediated Immunity in the Immunosenescence Process

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Immunology of Aging

Abstract

Immunosenescence contributes to render older adults more susceptible to pathogens and to develop main age-related diseases. With the ever-increasing rise in the number and proportion of older persons worldwide, one of the challenges of a “long-life society” is to ensure that the years gained are not only healthy and disability-free years but also offering a good quality of life. In this perspective, recent research has concentrated on identifying the factors hindering healthy ageing, and among them, the age-related changes of the immune system have thus been particularly investigated. With respect to its central role in orchestrating the immune response, this chapter describes the main features of T cell-mediated immune senescence and the underlying mechanisms contributing to this state of increased vulnerability. Furthermore, it will explore the means by which T cell functions could be identified by using biomarkers.

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Authors and Affiliations

  1. Nescens Centre of Preventive Medicine, Clinique of Genolier, Genolier, Switzerland

    Pierre Olivier Lang MD, MPH, PD, PhD

  2. Translational Medicine Research Group, School of Health, Cranfield University, Cranfield, UK

    Pierre Olivier Lang MD, MPH, PD, PhD

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Correspondence to Pierre Olivier Lang MD, MPH, PD, PhD .

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  1. Department of Immunology, Tehran University of Medical Sciences School of Medicine, Tehran, Iran

    Ahmad Massoud

  2. Children's Medical Center Hospital, Tehran University of Medical Sciences Research Center for Immunodeficiencies, Tehran, Iran

    Nima Rezaei

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Lang, P.O. (2014). T Cell-Mediated Immunity in the Immunosenescence Process. In: Massoud, A., Rezaei, N. (eds) Immunology of Aging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-39495-9_10

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