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Human Fungal Pathogens pp 161–176Cite as

9 Mucosal Immunology in Candida albicans Infection

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Part of the book series: The Mycota ((MYCOTA,volume 12))

Abstract

The human pathogenic fungus Candida albicans is the predominant cause of both superficial and invasive forms of candidiasis. Clinical observations suggest that mucocutaneous Candida infections are commonly associated with defective cell-mediated immune responses. The importance of the mucosal immune system as a first-line defence against pathogenic challenge has long been recognized. Over the last decade, the identity of many key molecules mediating host defence have been identified. Central to these developments is the discovery of pattern recognition receptors such as Toll-like receptors and C-type lectin receptors that induce innate immune responses and also modulate cellular and humoral adaptive immunity during Candida infections. We address the most relevant pattern recognition receptors and their signalling mechanisms in oral mucosa to gain a better understanding of their contributions to antifungal immunity at mucosal surfaces.

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Acknowledgements

This work was supported by the BMBF (0315409B), Deutsche Forschungsgemeinschaft (Sch897/1-3, graduate college 685) and by a NIDCR grant R01 DE017514-01. J.N. and D.M are funded by the MRC (MR-J008303-1) and BBSRC (BB-J016411-1).

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Authors and Affiliations

  1. Institute of Pharmacy (Pharmacology and Toxicology), Freie Universität Berlin, 14195, Berlin, Germany

    Günther Weindl

  2. Department of Oral Immunology, Clinical and Diagnostic Sciences, King’s College London Dental Institute, King’s College London, SE1 9RT, London, UK

    Julian R. Naglik & David L. Moyes

  3. Department of Dermatology, Eberhard Karls University Tübingen, 72076, Tübingen, Germany

    Martin Schaller

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  1. Günther Weindl
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  2. Julian R. Naglik
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  3. David L. Moyes
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  4. Martin Schaller
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Correspondence to Martin Schaller .

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  1. Friedrich Schiller University of Jena, Jena, Germany

    Oliver Kurzai

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Weindl, G., Naglik, J.R., Moyes, D.L., Schaller, M. (2014). 9 Mucosal Immunology in Candida albicans Infection. In: Kurzai, O. (eds) Human Fungal Pathogens. The Mycota, vol 12. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-39432-4_9

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